Publications by authors named "OH Olsen"

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Challenging activity and signaling bias in tachykinin NK1 and NK2 receptors by truncated neuropeptides.
Jacob E Petersen, Artem Pavlovskyi, Jesper J Madsen, Thue W Schwartz, Thomas M Frimurer, Ole H Olsen

J Biol Chem· June 2025

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The intricate allostery in factor VIIa: triggering the trigger.
Jesper J Madsen, Egon Persson, Ole H Olsen

J Thromb Haemost· January 2025

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Molecular determinants of neuropeptide-mediated activation mechanisms in tachykinin NK1 and NK2 receptors.
Jacob E Petersen, Artem Pavlovskyi, Jesper J Madsen, Thue W Schwartz, Thomas M Frimurer, Ole H Olsen

J Biol Chem· December 2024

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A bispecific antibody approach for the potential prophylactic treatment of inherited bleeding disorders.
Prafull S Gandhi, Minka Zivkovic, Henrik Østergaard, Amalie C Bonde, Torben Elm, Ole H Olsen, Eva H N Olsen

Nat Cardiovasc Res· February 2024

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Deciphering specificity and cross-reactivity in tachykinin NK1 and NK2 receptors.
Jesper J Madsen, Jacob E Petersen, Dan P Christensen, Jakob B Hansen, Thue W Schwartz, Ole H Olsen

J Biol Chem· December 2023

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Mechanistic basis of GPCR activation explored by ensemble refinement of crystallographic structures.
Jesper J Madsen, Libin Ye, Thomas M Frimurer, Ole H Olsen

Protein Sci· November 2022

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The functional role of the autolysis loop in the regulation of factor X upon hemostatic response.
Amalie Carnbring Bonde, Jacob Lund, Jens Jacob Hansen, Jakob Rahr Winther, Per Franklin Nielsen, Ole Hvilsted Olsen

J Thromb Haemost· March 2022

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A systematic approach for evaluating the role of surface-exposed loops in trypsin-like serine proteases applied to the 170 loop in coagulation factor VIIa.
Anders B Sorensen, Per Jr Greisen, Jesper J Madsen, Jacob Lund, Gorm Andersen, Ole H Olsen

Sci Rep· March 2022

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Conformational Plasticity-Rigidity Axis of the Coagulation Factor VII Zymogen Elucidated by Atomistic Simulations of the N-Terminally Truncated Factor VIIa Protease Domain.
Jesper J Madsen, Ole H Olsen

Biomolecules· April 2021

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Beating tissue factor at its own game: Design and properties of a soluble tissue factor-independent coagulation factor VIIa.
Anders B Sorensen, Inga Tuneew, L Anders Svensson, Egon Persson, Henrik Østergaard, Ole H Olsen

J Biol Chem· January 2020

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Allostery in Coagulation Factor VIIa Revealed by Ensemble Refinement of Crystallographic Structures.
Anders B Sorensen, Jesper J Madsen, Thomas M Frimurer, Michael T Overgaard, Prafull S Gandhi, Ole H Olsen

Biophys J· May 2019

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Evolutionary conservation of the allosteric activation of factor VIIa by tissue factor in lamprey: comment.
J J Madsen, E Persson, O H Olsen

J Thromb Haemost· July 2018

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Engineering of a membrane-triggered activity switch in coagulation factor VIIa.
Anders L Nielsen, Anders B Sorensen, Heidi L Holmberg, Prafull S Gandhi, Johan Karlsson, Ole H Olsen

Proc Natl Acad Sci U S A· November 2017

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Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site.
Line Hyltoft Kristensen, Ole H Olsen, Grant E Blouse, Hans Brandstetter

Biochem J· August 2016

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Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity.
Anders B Sorensen, Jesper J Madsen, L Anders Svensson, Anette A Pedersen, Henrik Østergaard, Ole H Olsen

J Biol Chem· February 2016

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Membrane Interaction of the Factor VIIIa Discoidin Domains in Atomistic Detail.
Jesper J Madsen, Y Zenmei Ohkubo, Günther H Peters, Johan H Faber, Emad Tajkhorshid, Ole H Olsen

Biochemistry· October 2015

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Factor VIII Interacts with the Endocytic Receptor Low-density Lipoprotein Receptor-related Protein 1 via an Extended Surface Comprising "Hot-Spot" Lysine Residues.
Maartje van den Biggelaar, Jesper J Madsen, Johan H Faber, Marleen G Zuurveld, Carmen van der Zwaan, Ole H Olsen

J Biol Chem· July 2015

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Evidence for restricted reactivity of ADAMDEC1 with protein substrates and endogenous inhibitors.
Jacob Lund, Linda Troeberg, Henrik Kjeldal, Ole H Olsen, Hideaki Nagase

J Biol Chem· March 2015

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Tissue factor activates allosteric networks in factor VIIa through structural and dynamic changes.
J J Madsen, E Persson, O H Olsen

J Thromb Haemost· February 2015

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The length of the linker between the epidermal growth factor-like domains in factor VIIa is critical for a productive interaction with tissue factor.
Egon Persson, Jesper J Madsen, Ole H Olsen

Protein Sci· December 2014

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Sites involved in intra- and interdomain allostery associated with the activation of factor VIIa pinpointed by hydrogen-deuterium exchange and electron transfer dissociation mass spectrometry.
Hongjian Song, Ole H Olsen, Egon Persson, Kasper D Rand

J Biol Chem· December 2014

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ADAMDEC1 is a metzincin metalloprotease with dampened proteolytic activity.
Jacob Lund, Ole H Olsen, Esben S Sørensen, Henning R Stennicke, Helle H Petersen

J Biol Chem· July 2013

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Evaluation of the metal binding sites in a recombinant coagulation factor VIII identifies two sites with unique metal binding properties.
Lars Anders Svensson, Lars Thim, Ole Hvilsted Olsen, Else Marie Nicolaisen

Biol Chem· June 2013

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Vatreptacog alfa from conception to clinical proof of concept.
Egon Persson, Ole H Olsen, Søren E Bjørn, Mirella Ezban

Semin Thromb Hemost· April 2012

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Tissue factor and factor VIIa cross-species compatibility.
Tom Knudsen, Ole Hvilsted Olsen, Lars Christian Petersen

Front Biosci (Landmark Ed)· June 2011

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