Publications by authors named "Owen Witte"

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Translating Discovery into Impact: Owen Witte Talks with Caius Radu and Johannes Czernin About a Life Dedicated to Science and Discovery.
Owen Witte, Caius Radu, Johannes Czernin

J Nucl Med· August 2025

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Human cancer-targeted immunity via transgenic hematopoietic stem cell progeny.
Theodore S Nowicki, Nataly Naser Al Deen, Cole W Peters, Begoña Comin-Anduix, Egmidio Medina, Owen N Witte

Nat Commun· July 2025

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Transcriptional profiling clarifies a program of enzalutamide extreme non-response in lethal prostate cancer.
Anbarasu Kumaraswamy, Ya-Mei Hu, Joel A Yates, Chao Zhang, Eva Rodansky, Owen N Witte

NPJ Precis Oncol· July 2025

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Staggered immunization with mRNA vaccines encoding SARS-CoV-2 polymerase or spike antigens broadens the T cell epitope repertoire.
Evan R Abt, Alex K Lam, Miyako Noguchi, Khalid Rashid, Jami McLaughlin, Owen N Witte

Proc Natl Acad Sci U S A· December 2024

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PGC-1α drives small cell neuroendocrine cancer progression toward an ASCL1-expressing subtype with increased mitochondrial capacity.
Grigor Varuzhanyan, Chia-Chun Chen, Jack Freeland, Tian He, Wendy Tran, Owen N Witte

Proc Natl Acad Sci U S A· December 2024

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Genetic Screen in a Preclinical Model of Sarcoma Development Defines Drivers and Therapeutic Vulnerabilities.
Jack Freeland, Maria Muñoz, Edmond O'Donnell, Justin Langerman, Morgan Darrow, Owen N Witte

Clin Cancer Res· November 2024

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PGC-1α drives small cell neuroendocrine cancer progression towards an ASCL1-expressing subtype with increased mitochondrial capacity.
Grigor Varuzhanyan, Chia-Chun Chen, Jack Freeland, Tian He, Wendy Tran, Owen Witte

bioRxiv· July 2024

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Defining T cell receptor repertoires using nanovial-based binding and functional screening.
Doyeon Koo, Zhiyuan Mao, Robert Dimatteo, Miyako Noguchi, Natalie Tsubamoto, Owen N Witte

Proc Natl Acad Sci U S A· April 2024

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Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation.
Chia-Chun Chen, Wendy Tran, Kai Song, Tyler Sugimoto, Matthew B Obusan, Owen N Witte

Cancer Cell· December 2023

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Wild-type C-Raf gene dosage and dimerization drive prostate cancer metastasis.
Lisa Ta, Brandon L Tsai, Weixian Deng, Jihui Sha, Grigor Varuzhanyan, Owen N Witte

iScience· December 2023

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Dual-inhibitory domain iCARs improve the efficiency of the AND-NOT gate CAR T strategy.
Nathanael J Bangayan, Liang Wang, Giselle Burton Sojo, Miyako Noguchi, Donghui Cheng, Owen N Witte

Proc Natl Acad Sci U S A· November 2023

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The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer.
Arian Lundberg, Meng Zhang, Rahul Aggarwal, Haolong Li, Li Zhang, Owen N Witte

Cancer Res· August 2023

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The RNA-binding proteins hnRNP H and F regulate splicing of a MYC-dependent HRAS exon in prostate cancer cells.
Xinyuan Chen, Harry Taegyun Yang, Beatrice Zhang, John W Phillips, Donghui Cheng, Owen N Witte

Proc Natl Acad Sci U S A· July 2023

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IRIS: Discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing.
Yang Pan, John W Phillips, Beatrice D Zhang, Miyako Noguchi, Eric Kutschera, Owen N Witte

Proc Natl Acad Sci U S A· May 2023

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Targeting deoxycytidine kinase improves symptoms in mouse models of multiple sclerosis.
Bao Ying Chen, Jessica R Salas, Alyssa O Trias, Arely Perez Rodriguez, Jonathan E Tsang, Owen N Witte

Immunology· January 2023

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Defining T cell receptor repertoires using nanovial-based affinity and functional screening.
Doyeon Koo, Zhiyuan Mao, Robert Dimatteo, Natalie Tsubamoto, Miyako Noguchi, Owen N Witte

bioRxiv· January 2023

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The 5-Hydroxymethylcytosine Landscape of Prostate Cancer.
Martin Sjöström, Shuang G Zhao, Samuel Levy, Meng Zhang, Yuhong Ning, Owen N Witte

Cancer Res· November 2022

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Transcriptional profiling of matched patient biopsies clarifies molecular determinants of enzalutamide-induced lineage plasticity.
Thomas C Westbrook, Xiangnan Guan, Eva Rodansky, Diana Flores, Chia Jen Liu, Owen Witte

Nat Commun· September 2022

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Physical and in silico immunopeptidomic profiling of a cancer antigen prostatic acid phosphatase reveals targets enabling TCR isolation.
Zhiyuan Mao, Pavlo A Nesterenko, Jami McLaughlin, Weixian Deng, Giselle Burton Sojo, Owen N Witte

Proc Natl Acad Sci U S A· August 2022

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HLA-A02:01 restricted T cell receptors against the highly conserved SARS-CoV-2 polymerase cross-react with human coronaviruses.
Pavlo A Nesterenko, Jami McLaughlin, Brandon L Tsai, Giselle Burton Sojo, Donghui Cheng, Owen N Witte

Cell Rep· December 2021

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Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy.
Yan-Ruide Li, Yang Zhou, Yu Jeong Kim, Yanni Zhu, Feiyang Ma, Owen Witte

Cell Rep Med· November 2021

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RNA Dysregulation: An Expanding Source of Cancer Immunotherapy Targets.
Yang Pan, Kathryn E Kadash-Edmondson, Robert Wang, John Phillips, Song Liu, Owen N Witte

Trends Pharmacol Sci· April 2021

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Droplet-based mRNA sequencing of fixed and permeabilized cells by CLInt-seq allows for antigen-specific TCR cloning.
Pavlo A Nesterenko, Jami McLaughlin, Donghui Cheng, Nathanael J Bangayan, Giselle Burton Sojo, Owen N Witte

Proc Natl Acad Sci U S A· January 2021

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Targeting RET Kinase in Neuroendocrine Prostate Cancer.
Halena R VanDeusen, Johnny R Ramroop, Katherine L Morel, Song Yi Bae, Anjali V Sheahan, Owen N Witte

Mol Cancer Res· August 2020

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The DNA methylation landscape of advanced prostate cancer.
Shuang G Zhao, William S Chen, Haolong Li, Adam Foye, Meng Zhang, Owen Witte

Nat Genet· August 2020

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