Publications by authors named "P-R Kettle"

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Focused Structure-Based Virtual Screening Identifies Novel Inhibitors of SOS1.
Silvia Bonomo, Floriane Gibault, Sharan K Bagal, J Henry Blackwell, Jason Breed, Jason G Kettle

ACS Med Chem Lett· October 2025

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Hybrid Agricultural Monitoring System with Detachable, Biodegradable, and Printed pH Sensors with a Recyclable Wireless Sensor Network for Sustainable Sensor Systems.
Andrew Rollo, Joseph Cameron, Jose Diego Fernandes Dias, Radosław Cichocki, Beata Synkiewicz-Musialska, Jeff Kettle

ACS Appl Electron Mater· April 2025

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Highly Optimized CNS Penetrant Inhibitors of EGFR Exon20 Insertion Mutations.
William McCoull, Clare Thomson, Erin Braybrooke, Christina Chan, Nicola Colclough, Jason G Kettle

J Med Chem· February 2025

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Discovery and Optimization of Pyrazine Carboxamide AZ3246, a Selective HPK1 Inhibitor.
Jason D Shields, David Baker, Amber Y S Balazs, Gayathri Bommakanti, Robert Casella, Jason G Kettle

J Med Chem· February 2025

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Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRAS with Demonstrable CNS Penetration.
Jason G Kettle, Sharan K Bagal, Derek Barratt, Michael S Bodnarchuk, Scott Boyd

J Med Chem· July 2023

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Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS.
Jason G Kettle, Sharan K Bagal, Sue Bickerton, Michael S Bodnarchuk, Scott Boyd

J Med Chem· May 2022

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Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRAS.
Jason G Kettle, Sharan K Bagal, Sue Bickerton, Michael S Bodnarchuk, Jason Breed

J Med Chem· May 2020

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Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
Jason G Kettle, Rana Anjum, Evan Barry, Deepa Bhavsar, Crystal Brown

J Med Chem· October 2018

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