Publications by authors named "Pak Sham"

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Autism epidemiology in Hong Kong children and youths aged 6-17: Implications on autism screening and sex differences in the community.
Oscar Wh Wong, Sandra Sm Chan, Steven Wh Chau, Winnie Cw Chu, Carol Sw Ho, Pak Chung Sham

Autism· November 2025

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Endogenous fine-mapping and prioritization of functional regulatory elements in complex genetic loci.
Ke Zhao, Yao Zhou, Xueqi Wang, Zhao Wang, Xinran Xu, Pak Chung Sham

Cell Genom· November 2025

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Determinants of enduring major depressive episodes in the youth population of Hong Kong: The roles of comorbid psychopathology and stressful life events.
Stephanie Ming Yin Wong, Eric Yu Hai Chen, Yi Nam Suen, Jim van Os, Peter B Jones, Pak Chung Sham

Psychol Med· November 2025

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Stratifying variant deleteriousness and trait-modulating effect under human recent adaptation using the FIND model.
Xutong Fan, Dandan Huang, Zhikun Wu, Xinran Dong, Jianhua Wang, Pak Chung Sham

Genome Biol· October 2025

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Polygenic and Polyenvironment Interplay in Schizophrenia-Spectrum Disorder and Affective Psychosis; the EUGEI First Episode Study.
Victoria Rodriguez, Luis Alameda, Monica Aas, Charlotte Gayer-Anderson, Giulia Trotta, Pak C Sham

Schizophr Bull· September 2025

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The effect of prenatal psychotropic drug exposures on obstetric complications: 19-year population-based study.
Perry B M Leung, Evangelos Vassos, Ka-Wang Cheung, Kenneth C Y Wong, Na Zhan, Pak C Sham

Br J Psychiatry· September 2025

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TransferTWAS: A transfer learning framework for cross-tissue transcriptome-wide association study.
Daoyuan Lai, Han Wang, Tian Gu, Siqi Wu, Dajiang J Liu, Pak Chung Sham

Am J Hum Genet· August 2025

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Jumping to Conclusions and Facial Emotion Recognition in First-Episode Psychosis: Longitudinal Insights from the Gap Follow-Up Study.
Giada Tripoli, Victoria Rodriguez, Uzma Zahid, Giulia Trotta, Andrea Quattrone, Pak C Sham

Clin Neuropsychiatry· August 2025

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Common and rare variant analyses implicate late-infancy cerebellar development and immune genes in ADHD.
Yuanxin Zhong, Larry W Baum, Justin D Tubbs, Rui Ye, Lu Hua Chen, Pak C Sham

J Neurodev Disord· June 2025

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Multi-ancestry genome-wide association meta-analysis identifies novel associations and informs genetic risk prediction for Hirschsprung disease.
Yuanxin Zhong, Man-Ting So, Zuyi Ma, Detao Zhang, Yanbing Wang, Pak Chung Sham

EBioMedicine· May 2025

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Translational genomics of osteoarthritis in 1,962,069 individuals.
Konstantinos Hatzikotoulas, Lorraine Southam, Lilja Stefansdottir, Cindy G Boer, Merry-Lynn McDonald, Pak Chung Sham

Nature· May 2025

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Methylomic signature of current cannabis use in two first-episode psychosis cohorts.
Emma L Dempster, Chloe C Y Wong, Joe Burrage, Eilis Hannon, Diego Quattrone, Pak Sham

Mol Psychiatry· April 2025

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Multifaceted analysis of noncoding and coding de novo variants implicates NOTCH signaling pathway in tetralogy of Fallot in Chinese population.
Qiongfen Lin, Detao Zhang, Peter J Gruber, Paul Kwong-Hang Tam, Vincent Chi-Hang Lui, Pak Chung Sham

HGG Adv· April 2025

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Twelve-month prevalence of DSM-5 mental disorders and the psychosocial correlates- a child and adolescent psychiatric epidemiologic survey in Hong Kong SAR.
Sandra S M Chan, Oscar W H Wong, Samara Hussain, Kelvin K F Tsoi, Karen K Y Ma, Pak C Sham

Lancet Reg Health West Pac· April 2025

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Excess mortality and life-years lost in people diagnosed with depression: A 20-year population-based cohort study of 126,573 depressed individuals followed for 1,139,073 persons-years.
Heidi Ka Ying Lo, Joe Kwun Nam Chan, Corine Sau Man Wong, Ka Fai Chung, Christoph U Correll, Pak Chung Sham

Eur Neuropsychopharmacol· February 2025

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MAAT: a new nonparametric Bayesian framework for incorporating multiple functional annotations in transcriptome-wide association studies.
Han Wang, Xiang Li, Teng Li, Zhe Li, Pak Chung Sham

Genome Biol· February 2025

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Integrated Transcriptome Analysis Reveals Novel Molecular Signatures for Schizophrenia Characterization.
Tong Ni, Yu Sun, Zefeng Li, Tao Tan, Wei Han, Pak Sham

Adv Sci (Weinh)· January 2025

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The impact of schizophrenia genetic load and heavy cannabis use on the risk of psychotic disorder in the EU-GEI case-control and UK Biobank studies.
Isabelle Austin-Zimmerman, Edoardo Spinazzola, Diego Quattrone, Beatrice Wu-Choi, Giulia Trotta, Pak C Sham

Psychol Med· December 2024

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Association of neurotransmitter pathway polygenic risk with specific symptom profiles in psychosis.
Tracy L Warren, Justin D Tubbs, Tyler A Lesh, Mylena B Corona, Sarvenaz S Pakzad, Pak Chung Sham

Mol Psychiatry· August 2024

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Unraveling NEK4 as a Potential Drug Target in Schizophrenia and Bipolar I Disorder: A Proteomic and Genomic Approach.
Chengcheng Zhang, ZhiHui Yang, Xiaojing Li, Liansheng Zhao, Wanjun Guo, Pak Chung Sham

Schizophr Bull· August 2024

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Dysfunction of thalamocortical circuits in early-onset schizophrenia.
Jia Cai, Min Xie, Sugai Liang, Jinnan Gong, Wei Deng, Pak C Sham

Cereb Cortex· August 2024

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Temporal changes in brain morphology related to inflammation and schizophrenia: an omnigenic Mendelian randomization study.
Yunjia Liu, Hongyan Ren, Yamin Zhang, Wei Deng, Xiaohong Ma, Pak Sham

Psychol Med· July 2024

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Mendelian randomization: causal inference leveraging genetic data.
Lane G Chen, Justin D Tubbs, Zipeng Liu, Thuan-Quoc Thach, Pak C Sham

Psychol Med· June 2024

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Whole-exome sequencing in a Chinese sample provides preliminary evidence for the link between rare/low-frequency immune-related variants and early-onset schizophrenia.
Yuanxin Zhong, Justin D Tubbs, Perry B M Leung, Na Zhan, Tomy C K Hui, Pak C Sham

Asian J Psychiatr· June 2024

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INSIDER: Interpretable sparse matrix decomposition for RNA expression data analysis.
Kai Zhao, Sen Huang, Cuichan Lin, Pak Chung Sham, Hon-Cheong So

PLoS Genet· March 2024

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