Publications by authors named "Pak-Ho Chan"

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Development of Broad-Spectrum Antimicrobial Peptides through the Conjugation of FtsZ-Binding and Cell-Penetrating Peptides.
Ruo-Lan Du, Cheung-Hin Hung, Alan Siu-Lun Leung, Kang Ding, Wai-Po Kong, Pak-Ho Chan

ACS Infect Dis· August 2025

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Discovery of a novel class of rosmarinic acid derivatives as antibacterial agents: Synthesis, structure-activity relationship and mechanism of action.
Yong Wang, Zhiguang Liang, Yihui Cao, Cheung-Hin Hung, Ruolan Du, Pak-Ho Chan

Bioorg Chem· May 2024

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Fluorescently Modified NDM-1: A Versatile Drug Sensor for Rapid β-Lactam Antibiotic and Inhibitor Screening.
Sai-Fung Chung, Suet-Ying Tam, Wai-Ting Wong, Pui-Kin So, Wing-Lam Cheong, Pak-Ho Chan

ACS Omega· February 2024

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Gossypol acetate: A natural polyphenol derivative with antimicrobial activities against the essential cell division protein FtsZ.
Ruo-Lan Du, Ho-Yin Chow, Yu Wei Chen, Pak-Ho Chan, Richard A Daniel

Front Microbiol· January 2023

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The structural dynamics of full-length divisome transmembrane proteins FtsQ, FtsB, and FtsL in FtsQBL complex formation.
Wai-Po Kong, Furong Gong, Pui-Kin So, Yu Wai Chen, Pak-Ho Chan

J Biol Chem· August 2022

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Discovery of FtsZ inhibitors by virtual screening as antibacterial agents and study of the inhibition mechanism.
Ruo-Lan Du, Ning Sun, Yik-Hong Fung, Yuan-Yuan Zheng, Yu-Wei Chen, Pak-Ho Chan

RSC Med Chem· January 2022

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Method Based on the β-Lactamase PenPC Fluorescent Labeled for β-Lactam Antibiotic Quantification in Human Plasma.
Max Andresen, Kwok-Yin Wong, Yun-Chung Leung, Wai-Ting Wong, Pak-Ho Chan

Biomed Res Int· November 2016

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A fluorescein-labeled AmpC β-lactamase allows rapid characterization of β-lactamase inhibitors by real-time fluorescence monitoring of the β-lactamase-inhibitor interactions.
Man-Wah Tsang, Pak-Ho Chan, Sze-Yan Liu, Kwok-Yin Wong, Yun-Chung Leung

Biotechnol J· February 2016

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Catalytically impaired fluorescent class C β-lactamase enables rapid and sensitive cephalosporin detection by stabilizing fluorescence signals: implications for biosensor design.
Man-Wah Tsang, Pui-Kin So, Sze-Yan Liu, Chun-Wai Tsang, Pak-Ho Chan

Biotechnol J· January 2015

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Fluorescent TEM-1 β-lactamase with wild-type activity as a rapid drug sensor for in vitro drug screening.
Wing-Lam Cheong, Ming-San Tsang, Pui-Kin So, Wai-Hong Chung, Yun-Chung Leung, Pak-Ho Chan

Biosci Rep· September 2014

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An Amyloid-Fibril-Based Colorimetric Nanosensor for Rapid and Sensitive Chromium(VI) Detection.
Wai-Hong Leung, Lan Zou, Wai-Hung Lo, Pak-Ho Chan

Chempluschem· December 2013

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A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation.
Erwin De Genst, Pak-Ho Chan, Els Pardon, Shang-Te D Hsu, Janet R Kumita

J Phys Chem B· October 2013

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Identification of a new class of FtsZ inhibitors by structure-based design and in vitro screening.
Fung-Yi Chan, Ning Sun, Marco A C Neves, Polo Chun-Hung Lam, Wai-Hong Chung, Pak-Ho Chan, Tak-Hang Chan

J Chem Inf Model· August 2013

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Benzothiazole-substituted benzofuroquinolinium dye: a selective switch-on fluorescent probe for G-quadruplex.
Yu-Jing Lu, Siu-Cheong Yan, Fung-Yi Chan, Lan Zou, Wai-Hong Chung, Pak-Ho Chan

Chem Commun (Camb)· May 2011

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Engineered Amp C β-lactamase as a fluorescent screening tool for class C β-lactamase inhibitors.
Man-Wah Tsang, Pak-Ho Chan, Pui-Kin So, Dik-Lung Ma, Chun-Wai Tsang

Anal Chem· March 2011

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A
A switch-on fluorescence assay for bacterial β-lactamases with amyloid fibrils as fluorescence enhancer and visual tool.
Lan Zou, Wing-Lam Cheong, Wai-Hong Chung, Yun-Chung Leung, Kwok-Yin Wong, Pak-Ho Chan

Chemistry· December 2010

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Luminescent gold nanoparticles capped with tiopronin derivatives.
Kin-Ming Lam, Pak-Ho Chan, Kwok-Yin Wong

J Nanosci Nanotechnol· April 2009

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Trityl-derivatized carbohydrates immobilized on a polystyrene microplate.
Lan Zou, Hei-Leung Pang, Pak-Ho Chan, Zhi-Shu Huang, Lian-Quan Gu

Carbohydr Res· November 2008

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A robust ionic liquid as reaction medium and efficient organocatalyst for carbon dioxide fixation.
Wing-Leung Wong, Pak-Ho Chan, Zhong-Yuan Zhou, Kam-Han Lee, Kwong-Chak Cheung

ChemSusChem· October 2008

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E
Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils.
Pak-Ho Chan, Els Pardon, Linda Menzer, Erwin De Genst, Janet R Kumita

Biochemistry· October 2008

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Covalent immobilization of carbohydrates on sol-gel-coated microplates.
Lan Zou, Hei-Leung Pang, Pak-Ho Chan, Zhi-Shu Huang, Lian-Quan Gu

Analyst· September 2008

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Fluorophore-labeled beta-lactamase as a biosensor for beta-lactam antibiotics: a study of the biosensing process.
Pak-Ho Chan, Pui-Kin So, Dik-Lung Ma, Yanxiang Zhao, Tat-Shing Lai, Kwok-Chu Chan, Hoi-Wan Chan

J Am Chem Soc· May 2008

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A tricarbonyl rhenium(I) complex with a pendant pyrrolidinium moiety as a robust and recyclable catalyst for chemical fixation of carbon dioxide in ionic liquid.
Wing-Leung Wong, Kwong-Chak Cheung, Pak-Ho Chan, Zhong-Yuan Zhou, Kam-Han Lee

Chem Commun (Camb)· June 2007

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High-throughput determination of biochemical oxygen demand (BOD) by a microplate-based biosensor.
Hei-Leung Pang, Nga-Yan Kwok, Pak-Ho Chan, Chi-Hung Yeung, Waihung Lo

Environ Sci Technol· June 2007

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Fluorescein-labeled beta-lactamase mutant for high-throughput screening of bacterial beta-lactamases against beta-lactam antibiotics.
Pak-Ho Chan, Kwok-Chu Chan, Hong-Bing Liu, Wai-Hong Chung, Yun-Chung Leung

Anal Chem· August 2005

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