Publications by authors named "Pamela A Haile"

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Optimization of a Series of RIPK2 PROTACs.
Afjal H Miah, Ian E D Smith, Mark Rackham, Alina Mares, Aditya R Thawani, Pamela A Haile

J Med Chem· September 2021

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Understanding Pharmacokinetic Disconnect in Preclinical Species for 4-Aminoquinolines: Consequences of Low Permeability and High P-glycoprotein Efflux Ratio on Rat and Dog Oral Pharmacokinetics.
Mukesh K Mahajan, Elizabeth J Rivera, Helen H Sun, Rakesh Nagilla, Michael P DeMartino, Pamela A Haile

J Pharm Sci· October 2020

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Correction to Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.
Pamela A Haile, Linda N Casillas, Michael J Bury, John F Mehlmann, Robert Singhaus

ACS Med Chem Lett· June 2020

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Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2.
Alina Mares, Afjal H Miah, Ian E D Smith, Mark Rackham, Aditya R Thawani, Pamela A Haile

Commun Biol· March 2020

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Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors.
Curt D Haffner, Adam K Charnley, Christopher J Aquino, Linda Casillas, Máire A Convery, Pamela A Haile

ACS Med Chem Lett· November 2019

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Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[]thiazol-5-ylamino)-6-(-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.
Pamela A Haile, Linda N Casillas, Bartholomew J Votta, Gren Z Wang, Adam K Charnley

J Med Chem· July 2019

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Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.
Pamela A Haile, Linda N Casillas, Michael J Bury, John F Mehlmann, Robert Singhaus

ACS Med Chem Lett· October 2018

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The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase.
Pamela A Haile, Bartholomew J Votta, Robert W Marquis, Michael J Bury, John F Mehlmann

J Med Chem· May 2016

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Identification of selective small molecule inhibitors of the nucleotide-binding oligomerization domain 1 (NOD1) signaling pathway.
David J Rickard, Clark A Sehon, Viera Kasparcova, Lorena A Kallal, Pamela A Haile

PLoS One· October 2015

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RIP3 induces apoptosis independent of pronecrotic kinase activity.
Pratyusha Mandal, Scott B Berger, Sirika Pillay, Kenta Moriwaki, Chunzi Huang, Pamela A Haile

Mol Cell· November 2014

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Identification of benzimidazole diamides as selective inhibitors of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway.
David J Rickard, Clark A Sehon, Viera Kasparcova, Lorena A Kallal, Xin Zeng, Pamela A Haile

PLoS One· March 2014

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CCR2 receptor antagonists: optimization of biaryl sulfonamides to increase activity in whole blood.
Gren Z Wang, Pamela A Haile, Tom Daniel, Benjamin Belot, Andrew Q Viet

Bioorg Med Chem Lett· December 2011

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Enantioselective total synthesis of brevetoxin A: unified strategy for the B, E, G, and J subunits.
Michael T Crimmins, J Michael Ellis, Kyle A Emmitte, Pamela A Haile, Patrick J McDougall

Chemistry· September 2009

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Silylene-mediated ring contraction of homoallylic ethers to form allylic silanes.
Laura E Bourque, Pamela A Haile, K A Woerpel

J Org Chem· September 2009

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Silylene oxonium ylides: di-tert-butylsilylene insertion into C-O bonds.
Laura E Bourque, Pamela A Haile, Janice M N Loy, K A Woerpel

Tetrahedron· July 2009

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Total synthesis of brevetoxin A.
Michael T Crimmins, J Lucas Zuccarello, J Michael Ellis, Patrick J McDougall, Pamela A Haile

Org Lett· January 2009

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Ion-molecule chemistry within boron tribromide clusters: experiment and theory.
David A Hales, Kathryn E Kautzman, Nathan G Williams, Pamela A Haile, Michael P Barker

J Phys Chem A· March 2007

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