Publications by authors named "Pamela Garzone"

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Lemur tail kinase 3 serves as a predictor of patient outcomes and a target for the treatment of ovarian cancer.
Ghassan M Saed, Nicole M Fletcher, Harvey Sharma, Axel Stenmark Tullberg, Ella Ittner, Pamela D Garzone

Mol Ther Oncol· September 2024

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Model-Based Characterization of the Pharmacokinetics, Target Engagement Biomarkers, and Immunomodulatory Activity of PF-06342674, a Humanized mAb Against IL-7 Receptor-α, in Adults with Type 1 Diabetes.
Jason H Williams, Chandrasekhar Udata, Bishu J Ganguly, Samantha L Bucktrout, Tenshang Joh, Pamela D Garzone

AAPS J· January 2020

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Molecular Characterization of Familial Hypercholesterolemia in a North American Cohort.
Abhimanyu Garg, Sergio Fazio, P Barton Duell, Alexis Baass, Chandrasekhar Udata, Pamela D Garzone

J Endocr Soc· January 2020

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Immunomodulatory activity of humanized anti-IL-7R monoclonal antibody RN168 in subjects with type 1 diabetes.
Kevan C Herold, Samantha L Bucktrout, Xiao Wang, Bruce W Bode, Stephen E Gitelman, Pamela D Garzone

JCI Insight· December 2019

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Single and multiple ascending-dose study of glucagon-receptor antagonist RN909 in type 2 diabetes: a phase 1, randomized, double-blind, placebo-controlled trial.
Barry Gumbiner, Brooke Esteves, Vanessa Dell, Tenshang Joh, Pamela D Garzone

Endocrine· November 2018

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Effects of 12 weeks of treatment with intravenously administered bococizumab, a humanized monoclonal antibody blocking proprotein convertase subtilisin/kexin type 9, in hypercholesterolemic subjects on high-dose statin.
Sergio Fazio, David G Robertson, Tenshang Joh, Hong Wan, Tom Riel, Pamela D Garzone

Cardiovasc Ther· February 2018

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The effects of single- and multiple-dose administration of bococizumab (RN316/PF-04950615), a humanized IgG2Δa monoclonal antibody binding proprotein convertase subtilisin/kexin type 9, in hypercholesterolemic subjects treated with and without atorvastatin: Results from four phase I studies.
Barry Gumbiner, Tenshang Joh, Hong Liang, Hong Wan, Matteo Levisetti, Pamela D Garzone

Cardiovasc Ther· February 2018

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Effects of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibition with Bococizumab on Lipoprotein Particles in Hypercholesterolemic Subjects.
Hong Wan, Barry Gumbiner, Tenshang Joh, Tom Riel, Chandrasekhar Udata, Pamela D Garzone

Clin Ther· November 2017

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A Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for Bococizumab, a Humanized Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9, and Its Application in Early Clinical Development.
Chandrasekhar Udata, Pamela D Garzone, Barry Gumbiner, Tenshang Joh, Hong Liang

J Clin Pharmacol· July 2017

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Safety and tolerability of LBR-101, a humanized monoclonal antibody that blocks the binding of CGRP to its receptor: Results of the Phase 1 program.
Marcelo E Bigal, Rafael Escandon, Michele Bronson, Sarah Walter, Maria Sudworth, Pamela Garzone

Cephalalgia· June 2014

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Pharmacokinetic Profile of Orally Administered Scyllo-Inositol (Elnd005) in Plasma, Cerebrospinal Fluid and Brain, and Corresponding Effect on Amyloid-Beta in Healthy Subjects.
Earvin Liang, Pamela Garzone, Jesse M Cedarbaum, Martin Koller, Thao Tran

Clin Pharmacol Drug Dev· April 2013

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Increasing serum half-life and extending cholesterol lowering in vivo by engineering antibody with pH-sensitive binding to PCSK9.
Javier Chaparro-Riggers, Hong Liang, Rachel M DeVay, Lanfang Bai, Janette E Sutton, Pamela Garzone

J Biol Chem· March 2012

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Enhancement of the efficacy of an antagonist of an extracellular receptor by attachment to the surface of a biocompatible carrier.
Charles A Wartchow, Susan E Alters, Pamela D Garzone, Lingyun Li, Steven Choi

Pharm Res· October 2004

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Poly-(L)-glutamic acid-paclitaxel (CT-2103) [XYOTAX], a biodegradable polymeric drug conjugate: characterization, preclinical pharmacology, and preliminary clinical data.
Jack W Singer, Brian Baker, Peter De Vries, Anil Kumar, Scott Shaffer, Pamela Garzone

Adv Exp Med Biol· June 2003

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