Publications by authors named "Pascal Nicole"

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Pharmacodynamics of the orexin type 1 (OX) receptor in colon cancer cell models: A two-sided nature of antagonistic ligands resulting from partial dissociation of Gq.
Valérie Gratio, Paulina Dragan, Laurine Garcia, Loredana Saveanu, Pascal Nicole

Br J Pharmacol· April 2025

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Acinar-to-Ductal Metaplasia (ADM): On the Road to Pancreatic Intraepithelial Neoplasia (PanIN) and Pancreatic Cancer.
Louis Marstrand-Daucé, Diane Lorenzo, Anaïs Chassac, Pascal Nicole, Anne Couvelard

Int J Mol Sci· June 2023

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The Orexin receptors: Structural and anti-tumoral properties.
Alain Couvineau, Pascal Nicole, Valérie Gratio, Thierry Voisin

Front Endocrinol (Lausanne)· August 2022

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The Orexin-A/OX1R System Induces Cell Death in Pancreatic Cancer Cells Resistant to Gemcitabine and Nab-Paclitaxel Treatment.
Thierry Voisin, Pascal Nicole, Valérie Gratio, Anaïs Chassac, Dounia Mansour

Front Oncol· June 2022

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Orexins: A promising target to digestive cancers, inflammation, obesity and metabolism dysfunctions.
Alain Couvineau, Thierry Voisin, Pascal Nicole, Valerie Gratio, Anne Blais

World J Gastroenterol· November 2021

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Orexins/Hypocretins and Cancer: A Neuropeptide as Emerging Target.
Couvineau Alain, Nicole Pascal, Gratio Valérie, Voisin Thierry

Molecules· August 2021

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Orexins as Novel Therapeutic Targets in Inflammatory and Neurodegenerative Diseases.
Alain Couvineau, Thierry Voisin, Pascal Nicole, Valérie Gratio, Catalina Abad

Front Endocrinol (Lausanne)· October 2019

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The Anti-tumoral Properties of Orexin/Hypocretin Hypothalamic Neuropeptides: An Unexpected Therapeutic Role.
Alain Couvineau, Stéphanie Dayot, Pascal Nicole, Valérie Gratio, Vinciane Rebours

Front Endocrinol (Lausanne)· September 2018

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Microvasculature alters the dispersion properties of shear waves--a multi-frequency MR elastography study.
Lauriane Jugé, Anne Petiet, Simon A Lambert, Pascal Nicole, Simon Chatelin

NMR Biomed· December 2015

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Crucial role of the orexin-B C-terminus in the induction of OX1 receptor-mediated apoptosis: analysis by alanine scanning, molecular modelling and site-directed mutagenesis.
Pascal Nicole, Pierre Couvineau, Nadege Jamin, Thierry Voisin, Alain Couvineau

Br J Pharmacol· November 2015

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Kallikrein-related peptidase 7 (KLK7) is a proliferative factor that is aberrantly expressed in human colon cancer.
Francine Walker, Pascal Nicole, Abdelhak Jallane, Antoninus Soosaipillai, Valentine Mosbach

Biol Chem· September 2014

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Spatial proximity between the VPAC1 receptor and the amino terminus of agonist and antagonist peptides reveals distinct sites of interaction.
Emilie Ceraudo, Régine Hierso, Yossan-Var Tan, Samuel Murail, Christiane Rouyer-Fessard, Pascal Nicole

FASEB J· May 2012

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Intestinal cell targeting of a stable recombinant Cu-Zn SOD from Cucumis melo fused to a gliadin peptide.
Laurent Intes, Muriel Bahut, Pascal Nicole, Alain Couvineau, Catherine Guette

J Biotechnol· May 2012

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The N-terminal parts of VIP and antagonist PG97-269 physically interact with different regions of the human VPAC1 receptor.
Emilie Ceraudo, Yossan-Var Tan, Pascal Nicole, Alain Couvineau, Marc Laburthe

J Mol Neurosci· November 2008

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Serine 447 in the carboxyl tail of human VPAC1 receptor is crucial for agonist-induced desensitization but not internalization of the receptor.
Jean-Claude Marie, Christiane Rouyer-Fessard, Alain Couvineau, Pascal Nicole, Hélène Devaud

Mol Pharmacol· December 2003

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Identification of cytoplasmic domains of hVPAC1 receptor required for activation of adenylyl cyclase. Crucial role of two charged amino acids strictly conserved in class II G protein-coupled receptors.
Alain Couvineau, Jean-Jacques Lacapere, Yossan-Var Tan, Christiane Rouyer-Fessard, Pascal Nicole

J Biol Chem· July 2003

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Human VPAC1 receptor selectivity filter. Identification of a critical domain for restricting secretin binding.
Kai Du, Alain Couvineau, Christiane Rouyer-Fessard, Pascal Nicole, Marc Laburthe

J Biol Chem· October 2002

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