Publications by authors named "Patrick Downey"

Claim this Profile
D
Differential role of C-terminal truncations on alpha-synuclein pathology and Lewy body formation.
Anne-Laure Mahul-Mellier, Melek Firat Altay, Niran Maharjan, Nadine Ait-Bouziad, Anass Chiki, Patrick Downey

NPJ Parkinsons Dis· August 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A high-fidelity microfluidic platform reveals retrograde propagation as the main mechanism of α-Synuclein spread in human neurons.
Rozan Vroman, Lorenzo de Lichtervelde, Karamjit Singh Dolt, Graham Robertson, Marco Kriek, Patrick Downey

NPJ Parkinsons Dis· April 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Two-color coincidence single-molecule pulldown for the specific detection of disease-associated protein aggregates.
Rebecca S Saleeb, Craig Leighton, Ji-Eun Lee, Judi O'Shaughnessy, Kiani Jeacock, Patrick Downey

Sci Adv· November 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Single-Molecule Two-Color Coincidence Detection of Unlabeled alpha-Synuclein Aggregates.
Alexandre Chappard, Craig Leighton, Rebecca S Saleeb, Kiani Jeacock, Sarah R Ball, Patrick Downey

Angew Chem Int Ed Engl· April 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Single-Molecule Two-Color Coincidence Detection of Unlabeled alpha-Synuclein Aggregates.
Alexandre Chappard, Craig Leighton, Rebecca S Saleeb, Kiani Jeacock, Sarah R Ball, Patrick Downey

Angew Chem Weinheim Bergstr Ger· April 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Artificial intelligence-based clustering and characterization of Parkinson's disease trajectories.
Colin Birkenbihl, Ashar Ahmad, Nathalie J Massat, Tamara Raschka, Andreja Avbersek, Patrick Downey

Sci Rep· February 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Monitoring of a progressive functional dopaminergic deficit in the A53T-AAV synuclein rats by combining 6-[F]fluoro-L-m-tyrosine imaging and motor performances analysis.
Guillaume Becker, Anne Michel, Mohamed Ali Bahri, Georges Mairet-Coello, Christian Lemaire, Patrick Downey

Neurobiol Aging· November 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A rapid α-synuclein seed assay of Parkinson's disease CSF panel shows high diagnostic accuracy.
Christina D Orrù, Thong C Ma, Andrew G Hughson, Bradley R Groveman, Ankit Srivastava, Patrick Downey

Ann Clin Transl Neurol· February 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody.
Marie Albert, Georges Mairet-Coello, Clément Danis, Sarah Lieger, Raphaëlle Caillierez, Patrick Downey

Brain· June 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Engineering synucleinopathy-resistant human dopaminergic neurons by CRISPR-mediated deletion of the SNCA gene.
Yixi Chen, Karamjit Singh Dolt, Marco Kriek, Terry Baker, Patrick Downey

Eur J Neurosci· February 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau.
Jean-Philippe Courade, Rachel Angers, Georges Mairet-Coello, Nathalie Pacico, Kerry Tyson, Patrick Downey

Acta Neuropathol· November 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Antiparkinsonian effects of the "Radiprodil and Tozadenant" combination in MPTP-treated marmosets.
Anne Michel, Jean-Marie Nicolas, Sarah Rose, Michael Jackson, Peter Colman, Patrick Downey

PLoS One· October 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
Behavioural Assessment of the A2a/NR2B Combination in the Unilateral 6-OHDA-Lesioned Rat Model: A New Method to Examine the Therapeutic Potential of Non-Dopaminergic Drugs.
Anne Michel, Patrick Downey, Xavier Van Damme, Catherine De Wolf, Rainer Schwarting

PLoS One· May 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
U
Unprecedented therapeutic potential with a combination of A2A/NR2B receptor antagonists as observed in the 6-OHDA lesioned rat model of Parkinson's disease.
Anne Michel, Patrick Downey, Jean-Marie Nicolas, Dieter Scheller

PLoS One· January 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Achieving the opt out for Medicare physician supervision for nurse anesthetists.
Patrick M Downey

AANA J· April 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Identification of single nucleotide polymorphisms of the human metabotropic glutamate receptor 1 gene and pharmacological characterization of a P993S variant.
Patrick M Downey, Roberta Petrò, Jason S Simon, David Devlin, Gianluca Lozza

Biochem Pharmacol· April 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Ecdysone-based system for controlled inducible expression of metabotropic glutamate receptor subtypes 2, 5, and 8.
Patrick M Downey, Gianluca Lozza, Roberta Petrò, Enrica Diodato, Chiara Foglia

J Biomol Screen· December 2005

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
DKT1, a novel K+ channel from carrot, forms functional heteromeric channels with KDC1.
Elide Formentin, Serena Varotto, Alex Costa, Patrick Downey, Monica Bregante

FEBS Lett· August 2004

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
Histidines are responsible for zinc potentiation of the current in KDC1 carrot channels.
Cristiana Picco, Monica Bregante, Alessia Naso, Paola Gavazzo, Alex Costa, Patrick Downey

Biophys J· January 2004

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis