Publications by authors named "Patrick Ernst"

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A nucleotide-independent, pan-RAS-targeted DARPin elicits anti-tumor activity in a multimodal manner.
Jonas N Kapp, Wouter P R Verdurmen, Jonas V Schaefer, Kari Kopra, Gabriela Nagy-Davidescu, Patrick Ernst

Mol Oncol· November 2025

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Optogenetic mitochondrial preconditioning enhances cardiomyocyte survival under stress.
Seulhee Kim, Hwayeon Lim, Patrick Ernst, Li Zhu, Jiashuai Zhang

J Mol Cell Cardiol· August 2025

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Heterodimerization of staphylococcal phage φ2638A endolysin isoforms and their functional role in bacterial lysis.
Léa V Zinsli, Anna M Sobieraj, Jiemin Du, Patrick Ernst, Susanne Meile

Microlife· June 2025

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mLumiOpto Is a Mitochondrial-Targeted Gene Therapy for Treating Cancer.
Kai Chen, Patrick Ernst, Anusua Sarkar, Seulhee Kim, Yingnan Si

Cancer Res· December 2024

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Modular binder technology by NGS-aided, high-resolution selection in yeast of designed armadillo modules.
Yvonne Stark, Faye Menard, Jeliazko R Jeliazkov, Patrick Ernst, Anupama Chembath

Proc Natl Acad Sci U S A· July 2024

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An Innovative Mitochondrial-targeted Gene Therapy for Cancer Treatment.
Kai Chen, Patrick Ernst, Seulhee Kim, Yingnan Si, Tanvi Varadkar

bioRxiv· March 2024

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Unexpected dynamics in femtomolar complexes of binding proteins with peptides.
Stefano Cucuzza, Malgorzata Sitnik, Simon Jurt, Erich Michel, Wenzhao Dai, Patrick Ernst

Nat Commun· November 2023

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Characterization of the far-red fluorescent probe MitoView 633 for dynamic mitochondrial membrane potential measurement.
Patrick Ernst, Seulhee Kim, Zengqiao Yang, Xiaoguang Margaret Liu, Lufang Zhou

Front Physiol· October 2023

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Cardiac calcium regulation in human induced pluripotent stem cell cardiomyocytes: Implications for disease modeling and maturation.
Patrick Ernst, Philip A Bidwell, Michaela Dora, David D Thomas, Forum Kamdar

Front Cell Dev Biol· January 2023

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Optogenetic Studies of Mitochondria.
Kai Chen, Patrick Ernst, Xiaoguang Margaret Liu, Lufang Zhou

Methods Mol Biol· July 2022

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Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization.
Nikolas Friedrich, Emanuel Stiegeler, Matthias Glögl, Thomas Lemmin, Simon Hansen, Patrick Ernst

Nat Commun· November 2021

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Anti-SSTR2 antibody-drug conjugate for neuroendocrine tumor therapy.
Yingnan Si, Seulhee Kim, Jianfa Ou, Yun Lu, Patrick Ernst

Cancer Gene Ther· August 2021

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Ablation of lncRNA attenuates pathological hypertrophy and heart failure.
Liu Yang, Jianxin Deng, Wenxia Ma, Aijun Qiao, Shiyue Xu, Patrick Ernst

Theranostics· August 2021

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Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action.
Florian Kast, Martin Schwill, Jakob C Stüber, Svende Pfundstein, Gabriela Nagy-Davidescu, Patrick Ernst

Nat Commun· June 2021

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Antibody-Drug Conjugate to Treat Meningiomas.
Kai Chen, Yingnan Si, Jianfa Ou, Jia-Shiung Guan, Seulhee Kim, Patrick Ernst

Pharmaceuticals (Basel)· May 2021

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Investigation into the difference in mitochondrial-cytosolic calcium coupling between adult cardiomyocyte and hiPSC-CM using a novel multifunctional genetic probe.
Patrick Ernst, Kai Chen, Yawen Tang, Seulhee Kim, Jiashiung Guan

Pflugers Arch· March 2021

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Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Mattia Deluigi, Alexander Klipp, Christoph Klenk, Lisa Merklinger, Stefanie A Eberle, Patrick Ernst

Sci Adv· January 2021

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MitoQ regulates redox-related noncoding RNAs to preserve mitochondrial network integrity in pressure-overload heart failure.
Seulhee Kim, Jiajia Song, Patrick Ernst, Mary N Latimer, Chae-Myeong Ha

Am J Physiol Heart Circ Physiol· March 2020

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Chaperone-assisted structure elucidation with DARPins.
Peer Re Mittl, Patrick Ernst, Andreas Plückthun

Curr Opin Struct Biol· February 2020

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Structure-Guided Design of a Peptide Lock for Modular Peptide Binders.
Patrick Ernst, Franziska Zosel, Christian Reichen, Daniel Nettels, Benjamin Schuler

ACS Chem Biol· February 2020

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Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts.
Patrick Ernst, Annemarie Honegger, Floor van der Valk, Christina Ewald, Peer R E Mittl

Sci Rep· November 2019

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Structural analysis of biological targets by host:guest crystal lattice engineering.
Patrick Ernst, Andreas Plückthun, Peer R E Mittl

Sci Rep· October 2019

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Reprogramming Bacteriophage Host Range through Structure-Guided Design of Chimeric Receptor Binding Proteins.
Matthew Dunne, Beatrice Rupf, Marc Tala, Xhem Qabrati, Patrick Ernst

Cell Rep· October 2019

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Precisely Control Mitochondria with Light to Manipulate Cell Fate Decision.
Patrick Ernst, Ningning Xu, Jing Qu, Herbert Chen, Matthew S Goldberg

Biophys J· August 2019

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Enhancing the Engraftment of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes via a Transient Inhibition of Rho Kinase Activity.
Meng Zhao, Yawen Tang, Patrick J Ernst, Asher Kahn-Krell, Chengming Fan

J Vis Exp· July 2019

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