Publications by authors named "Patrick Groothuis"

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Preclinical Profile of BYON3521 Predicts an Effective and Safe MET Antibody-Drug Conjugate.
Patrick G Groothuis, Daniëlle C H Jacobs, Inge A T Hermens, Désirée Damming, Kim Berentsen

Mol Cancer Ther· June 2023

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Model Systems in Endometriosis Research: Translation, Translation, Translation!
Patrick Groothuis

Front Reprod Health· January 2022

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High Prevalence of 5T4/Trophoblast Glycoprotein in Soft Tissue Sarcomas.
Patrick Groothuis, Nicola Penel, Antoine Italiano, Nuria Kotecki, Fred Dijcks

Cancers (Basel)· September 2021

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A Platform for the Generation of Site-Specific Antibody-Drug Conjugates That Allows for Selective Reduction of Engineered Cysteines.
Ruud G E Coumans, Gerry J A Ariaans, Henri J Spijker, Pascal Renart Verkerk, Patrick H Beusker, Patrick G Groothuis

Bioconjug Chem· September 2020

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An objective and automated method for evaluating abdominal hyperalgesia in a rat model for endometriosis.
Mieke Aw van Aken, Patrick G Groothuis, Maria Panagiotou, Marcel van Duin, Annemiek W Nap

Lab Anim· August 2020

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Unraveling the Interaction between Carboxylesterase 1c and the Antibody-Drug Conjugate SYD985: Improved Translational PK/PD by Using Ces1c Knockout Mice.
Ruud Ubink, Eef H C Dirksen, Myrthe Rouwette, Ebo S Bos, Ingrid Janssen, Patrick G Groothuis

Mol Cancer Ther· November 2018

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Is it time for a paradigm shift in drug research and development in endometriosis/adenomyosis?
Sun-Wei Guo, Patrick G Groothuis

Hum Reprod Update· September 2018

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Drug Development in Endometriosis and Adenomyosis: It Takes More Than Just Good Science.
Patrick G Groothuis, Sun-Wei Guo

Reprod Sci· September 2018

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Endometriosis is associated with aberrant metabolite profiles in plasma.
Sophia Letsiou, Dirkje P Peterse, Amelie Fassbender, Margriet M Hendriks, Niels J van den Broek, Patrick G Groothuis

Fertil Steril· March 2017

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The Preclinical Profile of the Duocarmycin-Based HER2-Targeting ADC SYD985 Predicts for Clinical Benefit in Low HER2-Expressing Breast Cancers.
Miranda M C van der Lee, Patrick G Groothuis, Ruud Ubink, Monique A J van der Vleuten, Tanja A van Achterberg

Mol Cancer Ther· March 2015

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Preclinical profile of the HER2-targeting ADC SYD983/SYD985: introduction of a new duocarmycin-based linker-drug platform.
Wim Dokter, Ruud Ubink, Miranda van der Lee, Monique van der Vleuten, Tanja van Achterberg, Patrick Groothuis

Mol Cancer Ther· November 2014

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Sex disparity in colonic adenomagenesis involves promotion by male hormones, not protection by female hormones.
James M Amos-Landgraf, Jarom Heijmans, Mattheus C B Wielenga, Elisa Dunkin, Kathy J Krentz, Patrick G Groothuis

Proc Natl Acad Sci U S A· November 2014

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Oestrogens promote tumorigenesis in a mouse model for colitis-associated cancer.
Jarom Heijmans, Mattheus C B Wielenga, Sanne Liesbeth Rosekrans, Jooske F van Lidth de Jeude, Joris Roelofs, Patrick Groothuis

Gut· February 2014

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Correction: Intestinal Tumorigenesis Is Not Affected by Progesterone Signaling in Rodent Models.
Jarom Heijmans, Vanesa Muncan, Rutger J Jacobs, Eveline S M de Jonge-Muller, Laura Graven, Patrick G Groothuis

PLoS One· June 2013

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Intestinal tumorigenesis is not affected by progesterone signaling in rodent models.
Jarom Heijmans, Vanesa Muncan, Rutger J Jacobs, Eveline S M de Jonge-Muller, Laura Graven, Patrick G Groothuis

PLoS One· December 2011

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Deoxyribonucleic acid methyltransferases and methyl-CpG-binding domain proteins in human endometrium and endometriosis.
Kim J A F van Kaam, Bert Delvoux, Andrea Romano, Thomas D'Hooghe, Gerard A J Dunselman, Patrick G Groothuis

Fertil Steril· March 2011

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Olfactomedin-4 regulation by estrogen in the human endometrium requires epidermal growth factor signaling.
Hellen Dassen, Chamindie Punyadeera, Bert Delvoux, Iris Schulkens, Claudia Marchetti, Patrick Groothuis

Am J Pathol· November 2010

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Identification of novel ER-alpha target genes in breast cancer cells: gene- and cell-selective co-regulator recruitment at target promoters determines the response to 17beta-estradiol and tamoxifen.
Andrea Romano, Michiel Adriaens, Sabine Kuenen, Bert Delvoux, Gerard Dunselman, Patrick Groothuis

Mol Cell Endocrinol· January 2010

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Increased production of 17beta-estradiol in endometriosis lesions is the result of impaired metabolism.
Bert Delvoux, Patrick Groothuis, Thomas D'Hooghe, Cleophas Kyama, Gerard Dunselman

J Clin Endocrinol Metab· March 2009

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Oral contraceptives prevent the development of endometriosis in the chicken chorioallantoic membrane model.
Annemiek W Nap, Patrick G Groothuis, Chamindie Punyadeera, Ludger Klein-Hitpass, Rik Kamps

Contraception· September 2008

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Antiangiogenic and vascular-disrupting agents in endometriosis: pitfalls and promises.
Anne Van Langendonckt, Jacques Donnez, Sylvie Defrère, Gerard A J Dunselman, Patrick G Groothuis

Mol Hum Reprod· May 2008

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Role and regulation of the serum- and glucocorticoid-regulated kinase 1 in fertile and infertile human endometrium.
Fakhera Feroze-Zaidi, Luca Fusi, Masashi Takano, Jenny Higham, Madhuri S Salker, Patrick G Groothuis

Endocrinology· October 2007

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The PROGINS polymorphism of the human progesterone receptor diminishes the response to progesterone.
Andrea Romano, Bert Delvoux, Dagmar-Christiane Fischer, Patrick Groothuis

J Mol Endocrinol· February 2007

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TP53 overexpression in recurrent endometrial carcinoma.
Johanna M A Pijnenborg, Leonie van de Broek, Geeske C Dam de Veen, Guido M J M Roemen, Jelte de Haan, Patrick G Groothuis

Gynecol Oncol· February 2006

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Update on endometriosis.
Lone Hummelshoj, Andrew Prentice, Patrick Groothuis

Womens Health (Lond)· January 2006

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