Publications by authors named "Patrick Hsu"

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Site-specific DNA insertion into the human genome with engineered recombinases.
Alison Fanton, Liam J Bartie, Juliana Q Martins, Vincent Q Tran, Laine Goudy, Patrick D Hsu

Nat Biotechnol· November 2025

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Megabase-scale human genome rearrangement with programmable bridge recombinases.
Nicholas T Perry, Liam J Bartie, Dhruva Katrekar, Gabriel A Gonzalez, Matthew G Durrant, Patrick D Hsu

Science· September 2025

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Virtual Cell Challenge: Toward a Turing test for the virtual cell.
Yusuf H Roohani, Tony J Hua, Po-Yuan Tung, Lexi R Bounds, Feiqiao B Yu, Benjamin Hsu, Patrick D Hsu

Cell· June 2025

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Simulating 500 million years of evolution with a language model.
Thomas Hayes, Roshan Rao, Halil Akin, Nicholas J Sofroniew, Deniz Oktay, Patrick D Hsu

Science· February 2025

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How to build the virtual cell with artificial intelligence: Priorities and opportunities.
Charlotte Bunne, Yusuf Roohani, Yanay Rosen, Ankit Gupta, Xikun Zhang, Patrick D Hsu

Cell· December 2024

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Sequence modeling and design from molecular to genome scale with Evo.
Eric Nguyen, Michael Poli, Matthew G Durrant, Brian Kang, Dhruva Katrekar, Patrick D Hsu

Science· November 2024

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How to Build the Virtual Cell with Artificial Intelligence: Priorities and Opportunities.
Charlotte Bunne, Yusuf Roohani, Yanay Rosen, Ankit Gupta, Xikun Zhang, Patrick D Hsu

ArXiv· October 2024

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Bridge RNAs direct programmable recombination of target and donor DNA.
Matthew G Durrant, Nicholas T Perry, James J Pai, Aditya R Jangid, Januka S Athukoralage, Patrick D Hsu

Nature· June 2024

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Structural mechanism of bridge RNA-guided recombination.
Masahiro Hiraizumi, Nicholas T Perry, Matthew G Durrant, Teppei Soma, Naoto Nagahata, Patrick D Hsu

Nature· June 2024

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Designing Cell-Type-Specific Promoter Sequences Using Conservative Model-Based Optimization.
Aniketh Janardhan Reddy, Xinyang Geng, Michael H Herschl, Sathvik Kolli, Aviral Kumar, Patrick D Hsu

bioRxiv· June 2024

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Strategies for effectively modelling promoter-driven gene expression using transfer learning.
Aniketh Janardhan Reddy, Michael H Herschl, Xinyang Geng, Sathvik Kolli, Amy X Lu, Patrick D Hsu

bioRxiv· May 2024

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Bridge RNAs direct modular and programmable recombination of target and donor DNA.
Matthew G Durrant, Nicholas T Perry, James J Pai, Aditya R Jangid, Januka S Athukoralage, Patrick D Hsu

bioRxiv· January 2024

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Deep learning and CRISPR-Cas13d ortholog discovery for optimized RNA targeting.
Jingyi Wei, Peter Lotfy, Kian Faizi, Sara Baungaard, Emily Gibson, Patrick D Hsu

Cell Syst· December 2023

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The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression.
Jin Wei, Mia Madel Alfajaro, Wesley L Cai, Vincent R Graziano, Madison S Strine, Patrick D Hsu

PLoS Pathog· July 2023

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Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome.
Matthew G Durrant, Alison Fanton, Josh Tycko, Michaela Hinks, Sita S Chandrasekaran, Patrick D Hsu

Nat Biotechnol· April 2023

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Checkpoint kinase 1/2 inhibition potentiates anti-tumoral immune response and sensitizes gliomas to immune checkpoint blockade.
Crismita Dmello, Junfei Zhao, Li Chen, Andrew Gould, Brandyn Castro, Patrick D Hsu

Nat Commun· March 2023

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Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection.
Scott B Biering, Sylvia A Sarnik, Eleanor Wang, James R Zengel, Sarah R Leist, Patrick D Hsu

Nat Genet· August 2022

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Rapid detection of SARS-CoV-2 RNA in saliva via Cas13.
Sita S Chandrasekaran, Shreeya Agrawal, Alison Fanton, Aditya R Jangid, Bérénice Charrez, Patrick D Hsu

Nat Biomed Eng· August 2022

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What are the current bottlenecks in developing and applying CRISPR technologies?
Elizabeth H Kellogg, Jonathan Gootenberg, Omar Abudayyeh, Alan S L Wong, James E Dahlman, Patrick D Hsu

Cell Syst· August 2022

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Translocon-associated Protein Subunit SSR3 Determines and Predicts Susceptibility to Paclitaxel in Breast Cancer and Glioblastoma.
Crismita Dmello, Aarón Sonabend, Victor A Arrieta, Daniel Y Zhang, Deepak Kanojia, Patrick Hsu

Clin Cancer Res· July 2022

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Publisher Correction: Accelerated RNA detection using tandem CRISPR nucleases.
Tina Y Liu, Gavin J Knott, Dylan C J Smock, John J Desmarais, Sungmin Son, Patrick D Hsu

Nat Chem Biol· November 2021

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Accelerated RNA detection using tandem CRISPR nucleases.
Tina Y Liu, Gavin J Knott, Dylan C J Smock, John J Desmarais, Sungmin Son, Patrick D Hsu

Nat Chem Biol· September 2021

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Rapid, point-of-care molecular diagnostics with Cas13.
Shreeya Agrawal, Alison Fanton, Sita S Chandrasekaran, Bérénice Charrez, Arturo M Escajeda, Patrick D Hsu

medRxiv· April 2021

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Accelerated RNA detection using tandem CRISPR nucleases.
Tina Y Liu, Gavin J Knott, Dylan C J Smock, John J Desmarais, Sungmin Son, Patrick D Hsu

medRxiv· March 2021

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