Publications by authors named "Patrick L Splinter"

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Mitochondrial RNA cytosolic leakage drives the SASP.
Stella Victorelli, Madeline Eppard, Hélène Martini, Seung-Hwa Woo, Stacia P A Everts, Patrick L Splinter

Nat Commun· December 2025

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Differential MYC Phosphorylation Drives the Divergent Cholangiocyte Response to Stress.
Steven P O'Hara, Patrick L Splinter, Antonia Felzen, Carys A Turner, Olivia T Morgenthaler

Cell Mol Gastroenterol Hepatol· September 2025

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Mitochondrial RNA cytosolic leakage drives the SASP.
Stella Victorelli, Madeline Eppard, Seung-Hwa Woo, Stacia P A Everts, Helene Martini, Patrick L Splinter

Res Sq· August 2024

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The Epigenetic Reader, Bromodomain Containing 2, Mediates Cholangiocyte Senescence via Interaction With ETS Proto-Oncogene 1.
Jeong-Han Kang, Patrick L Splinter, Christy E Trussoni, Nicholas E Pirius, Gregory J Gores

Gastroenterology· July 2023

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Senescent cholangiocytes release extracellular vesicles that alter target cell phenotype via the epidermal growth factor receptor.
Mohammed S Al Suraih, Christy E Trussoni, Patrick L Splinter, Nicholas F LaRusso, Steven P O'Hara

Liver Int· October 2020

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The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1.
Steven P O'Hara, Patrick L Splinter, Christy E Trussoni, Maria Eugenia Guicciardi, Noah P Splinter

J Biol Chem· December 2019

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Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice.
Maria Eugenia Guicciardi, Christy E Trussoni, Anuradha Krishnan, Steven F Bronk, Maria J Lorenzo Pisarello, Patrick L Splinter

J Hepatol· September 2018

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Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2 ) mice.
Anja Moncsek, Mohammed S Al-Suraih, Christy E Trussoni, Steven P O'Hara, Patrick L Splinter

Hepatology· January 2018

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ETS Proto-oncogene 1 Transcriptionally Up-regulates the Cholangiocyte Senescence-associated Protein Cyclin-dependent Kinase Inhibitor 2A.
Steven P O'Hara, Patrick L Splinter, Christy E Trussoni, Maria J Lorenzo Pisarello, Lorena Loarca, Noah S Splinter

J Biol Chem· March 2017

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Lipopolysaccharide (LPS)-Induced Biliary Epithelial Cell NRas Activation Requires Epidermal Growth Factor Receptor (EGFR).
Christy E Trussoni, James H Tabibian, Patrick L Splinter, Steven P O'Hara

PLoS One· January 2016

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Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis.
James H Tabibian, Steven P O'Hara, Christy E Trussoni, Pamela S Tietz, Patrick L Splinter

Hepatology· January 2016

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Characterization of cultured cholangiocytes isolated from livers of patients with primary sclerosing cholangitis.
James H Tabibian, Christy E Trussoni, Steven P O'Hara, Patrick L Splinter, Julie K Heimbach

Lab Invest· October 2014

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Cholangiocyte senescence by way of N-ras activation is a characteristic of primary sclerosing cholangitis.
James H Tabibian, Steven P O'Hara, Patrick L Splinter, Christy E Trussoni, Nicholas F LaRusso

Hepatology· June 2014

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Centrosomal abnormalities characterize human and rodent cystic cholangiocytes and are associated with Cdc25A overexpression.
Tatyana V Masyuk, Seung-Ok Lee, Brynn N Radtke, Angela J Stroope, Bing Huang, Patrick L Splinter

Am J Pathol· January 2014

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Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling.
Anatoliy I Masyuk, Bing Q Huang, Brynn N Radtke, Gabriella B Gajdos, Patrick L Splinter

Am J Physiol Gastrointest Liver Physiol· June 2013

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Micro-computed tomography and nuclear magnetic resonance imaging for noninvasive, live-mouse cholangiography.
James H Tabibian, Slobodan I Macura, Steven P O'Hara, Jeff L Fidler, James F Glockner, Patrick L Splinter

Lab Invest· June 2013

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The dynamic biliary epithelia: molecules, pathways, and disease.
Steven P O'Hara, James H Tabibian, Patrick L Splinter, Nicholas F LaRusso

J Hepatol· March 2013

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Aquaporin-1 promotes angiogenesis, fibrosis, and portal hypertension through mechanisms dependent on osmotically sensitive microRNAs.
Robert C Huebert, Kumaravelu Jagavelu, Helen I Hendrickson, Meher M Vasdev, Juan P Arab, Patrick L Splinter

Am J Pathol· October 2011

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Cholangiocyte N-Ras protein mediates lipopolysaccharide-induced interleukin 6 secretion and proliferation.
Steven P O'Hara, Patrick L Splinter, Christy E Trussoni, Gabriella B Gajdos, Pooja N Lineswala

J Biol Chem· September 2011

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Immortalized liver endothelial cells: a cell culture model for studies of motility and angiogenesis.
Robert C Huebert, Kumaravelu Jagavelu, Ann F Liebl, Bing Q Huang, Patrick L Splinter

Lab Invest· December 2010

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Opisthorchis viverrini excretory/secretory products induce toll-like receptor 4 upregulation and production of interleukin 6 and 8 in cholangiocyte.
Kantima Ninlawan, Steve P O'Hara, Patrick L Splinter, Puangrat Yongvanit, Sasithorn Kaewkes

Parasitol Int· December 2010

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Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia.
Anatoliy I Masyuk, Bing Q Huang, Christopher J Ward, Sergio A Gradilone, Jesus M Banales, Patrick L Splinter

Am J Physiol Gastrointest Liver Physiol· October 2010

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B7-H1 expression in vestibular schwannomas.
David J Archibald, Brian A Neff, Stephen G Voss, Patrick L Splinter, Colin L W Driscoll

Otol Neurotol· August 2010

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Activation of Trpv4 reduces the hyperproliferative phenotype of cystic cholangiocytes from an animal model of ARPKD.
Sergio A Gradilone, Tatyana V Masyuk, Bing Q Huang, Jesus M Banales, Guillermo L Lehmann, Patrick L Splinter

Gastroenterology· July 2010

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Cholangiocyte myosin IIB is required for localized aggregation of sodium glucose cotransporter 1 to sites of Cryptosporidium parvum cellular invasion and facilitates parasite internalization.
Steven P O'Hara, Gabriella B Gajdos, Christy E Trussoni, Patrick L Splinter, Nicholas F LaRusso

Infect Immun· July 2010

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