Publications by authors named "Patrick Lechene"

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Distinct functions of cardiac β-adrenergic receptors in the T-tubule vs outer surface membrane.
George W P Madders, Marion Barthé, Flora Lefebvre, Emilie Langlois, Florence Lefebvre

Elife· September 2025

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Essential Role of the RIα Subunit of cAMP-Dependent Protein Kinase in Regulating Cardiac Contractility and Heart Failure Development.
Ibrahim Bedioune, Marine Gandon-Renard, Matthieu Dessillons, Aurélien Barthou, Audrey Varin

Circulation· December 2024

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Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure.
Sarah Karam, Jean Piero Margaria, Aurélia Bourcier, Delphine Mika, Audrey Varin

Circulation· July 2020

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Imipramine as an alternative to formamide to detubulate rat ventricular cardiomyocytes.
Aurelia Bourcier, Marion Barthe, Ibrahim Bedioune, Patrick Lechêne, Hela Ben Miled

Exp Physiol· August 2019

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Synergic PDE3 and PDE4 control intracellular cAMP and cardiac excitation-contraction coupling in a porcine model.
Delphine Mika, Pierre Bobin, Marta Lindner, Angele Boet, Amir Hodzic

J Mol Cell Cardiol· August 2019

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PDE4 and mAKAPβ are nodal organizers of β2-ARs nuclear PKA signalling in cardiac myocytes.
Ibrahim Bedioune, Florence Lefebvre, Patrick Lechêne, Audrey Varin, Valérie Domergue

Cardiovasc Res· September 2018

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Specific Activation of the Alternative Cardiac Promoter of by the Mineralocorticoid Receptor.
Thassio R Mesquita, Gaëlle Auguste, Débora Falcón, Gema Ruiz-Hurtado, Rogelio Salazar-Enciso

Circ Res· March 2018

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Standard and Strain Measurements by Echocardiography Detect Early Overloaded Right Ventricular Dysfunction: Validation against Hemodynamic and Myocyte Contractility Changes in a Large Animal Model.
Amir Hodzic, Pierre Bobin, Delphine Mika, Mohamed Ly, Florence Lefebvre

J Am Soc Echocardiogr· November 2017

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Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial Infarction.
Christiane Vettel, Marta Lindner, Matthias Dewenter, Kristina Lorenz, Constanze Schanbacher

Circ Res· January 2017

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[Cyclic nucleotide phosphodiesterases: role in the heart and therapeutic perspectives].
Ibrahim Bedioune, Pierre Bobin, Sarah Karam, Marta Lindner, Delphine Mika

Biol Aujourdhui· January 2017

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Interventricular differences in β-adrenergic responses in the canine heart: role of phosphodiesterases.
Cristina E Molina, Daniel M Johnson, Hind Mehel, Roel L H M G Spätjens, Delphine Mika

J Am Heart Assoc· June 2014

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Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes.
Zeineb Haj Slimane, Ibrahim Bedioune, Patrick Lechêne, Audrey Varin, Florence Lefebvre

Cardiovasc Res· April 2014

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Inactivation of the Carney complex gene 1 (PRKAR1A) alters spatiotemporal regulation of cAMP and cAMP-dependent protein kinase: a study using genetically encoded FRET-based reporters.
Laure Cazabat, Bruno Ragazzon, Audrey Varin, Marie Potier-Cartereau, Christophe Vandier

Hum Mol Genet· March 2014

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Differential regulation of cardiac excitation-contraction coupling by cAMP phosphodiesterase subtypes.
Delphine Mika, Pierre Bobin, Martine Pomérance, Patrick Lechêne, Ruth E Westenbroek

Cardiovasc Res· November 2013

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Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes.
Hind Mehel, Julius Emons, Christiane Vettel, Katrin Wittköpper, Danilo Seppelt

J Am Coll Cardiol· October 2013

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Spatiotemporal dynamics of beta-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes: role of phosphodiesterases.
Jérôme Leroy, Aniella Abi-Gerges, Viacheslav O Nikolaev, Wito Richter, Patrick Lechêne

Circ Res· May 2008

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Impaired voluntary running capacity of creatine kinase-deficient mice.
Iman Momken, Patrick Lechêne, Nathalie Koulmann, Dominique Fortin, Philippe Mateo

J Physiol· June 2005

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Voluntary physical activity alterations in endothelial nitric oxide synthase knockout mice.
Iman Momken, Patrick Lechêne, Renée Ventura-Clapier, Vladimir Veksler

Am J Physiol Heart Circ Physiol· August 2004

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Cardiac and skeletal muscle energy metabolism in heart failure: beneficial effects of voluntary activity.
Elvira De Sousa, Patrick Lechêne, Dominique Fortin, Benoît N'Guessan, Souad Belmadani

Cardiovasc Res· November 2002

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