Publications by authors named "Patrick Marcotte"

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Impact of an oral theophylline loading dose pre-electroconvulsive therapy: a retrospective study in patients with missed or inadequate seizures.
Michael F Kemp, Jacques Allard, Myriam Pâquet, Patrick Marcotte

J ECT· March 2015

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Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families.
Keith B Glaser, Junling Li, Patrick A Marcotte, Terrance J Magoc, Jun Guo

J Pharmacol Exp Ther· December 2012

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Pyrazole diaminopyrimidines as dual inhibitors of KDR and Aurora B kinases.
Michael L Curtin, H Robin Heyman, Robin R Frey, Patrick A Marcotte, Keith B Glaser

Bioorg Med Chem Lett· July 2012

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Exploration of diverse hinge-binding scaffolds for selective Aurora kinase inhibitors.
Zhiqin Ji, Yujia Dai, Cele Abad-Zapatero, Daniel H Albert, Jennifer J Bouska, Patrick A Marcotte

Bioorg Med Chem Lett· July 2012

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Thienopyridine ureas as dual inhibitors of the VEGF and Aurora kinase families.
Michael L Curtin, Robin R Frey, H Robin Heyman, Niru B Soni, Patrick A Marcotte

Bioorg Med Chem Lett· May 2012

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Discovery of potent and selective thienopyrimidine inhibitors of Aurora kinases.
William J McClellan, Yujia Dai, Cele Abad-Zapatero, Daniel H Albert, Jennifer J Bouska, Patrick A Marcotte

Bioorg Med Chem Lett· September 2011

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Synthesis and evaluation of a new generation of orally efficacious benzimidazole-based poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors as anticancer agents.
Yunsong Tong, Jennifer J Bouska, Paul A Ellis, Eric F Johnson, Joel Leverson, Patrick A Marcotte

J Med Chem· November 2009

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7-Aminopyrazolo[1,5-a]pyrimidines as potent multitargeted receptor tyrosine kinase inhibitors.
Robin R Frey, Michael L Curtin, Daniel H Albert, Keith B Glaser, Lori J Pease, Patrick Marcotte

J Med Chem· July 2008

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Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors.
Vijaya Gracias, Zhiqin Ji, Irini Akritopoulou-Zanze, Cele Abad-Zapatero, Jeffrey R Huth, Patrick A Marcotte

Bioorg Med Chem Lett· April 2008

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3-amino-benzo[d]isoxazoles as novel multitargeted inhibitors of receptor tyrosine kinases.
Zhiqin Ji, Asma A Ahmed, Daniel H Albert, Jennifer J Bouska, Peter F Bousquet, Patrick A Marcotte

J Med Chem· March 2008

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Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors.
Yujia Dai, Kresna Hartandi, Niru B Soni, Lori J Pease, David R Reuter, Patrick A Marcotte

Bioorg Med Chem Lett· January 2008

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1,4-Dihydroindeno[1,2-c]pyrazoles with acetylenic side chains as novel and potent multitargeted receptor tyrosine kinase inhibitors with low affinity for the hERG ion channel.
Jürgen Dinges, Daniel H Albert, Lee D Arnold, Kimba L Ashworth, Irini Akritopoulou-Zanze, Patrick A Marcotte

J Med Chem· May 2007

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ABT-869, a multitargeted receptor tyrosine kinase inhibitor: inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia.
Deepa B Shankar, Junling Li, Paul Tapang, J Owen McCall, Lori J Pease, Patrick A Marcotte

Blood· April 2007

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Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor.
Yujia Dai, Kresna Hartandi, Zhiqin Ji, Asma A Ahmed, Daniel H Albert, Patrick A Marcotte

J Med Chem· April 2007

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Thienopyridine urea inhibitors of KDR kinase.
H Robin Heyman, Robin R Frey, Peter F Bousquet, George A Cunha, Maria D Moskey, Patrick A Marcotte

Bioorg Med Chem Lett· March 2007

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Isothiazolopyrimidines and isoxazolopyrimidines as novel multi-targeted inhibitors of receptor tyrosine kinases.
Zhiqin Ji, Asma A Ahmed, Daniel H Albert, Jennifer J Bouska, Peter F Bousquet, Patrick A Marcotte

Bioorg Med Chem Lett· August 2006

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High-level bacterial expression and purification of human SirT2 protein for NMR studies.
Chaohong Sun, Danying Song, Patrick A Marcotte, Paul L Richardson, Philip J Hajduk

Protein Expr Purif· July 2006

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Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor.
Daniel H Albert, Paul Tapang, Terrance J Magoc, Lori J Pease, David R Reuter, Patrick A Marcotte

Mol Cancer Ther· April 2006

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Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors.
Jun Guo, Patrick A Marcotte, J Owen McCall, Yujia Dai, Lori J Pease

Mol Cancer Ther· April 2006

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Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors.
Yujia Dai, Yan Guo, Robin R Frey, Zhiqin Ji, Michael L Curtin, Patrick A Marcotte

J Med Chem· September 2005

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Fluorescence assay of SIRT protein deacetylases using an acetylated peptide substrate and a secondary trypsin reaction.
Patrick A Marcotte, Paul L Richardson, Jun Guo, Leo W Barrett, Nan Xu

Anal Biochem· September 2004

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A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units.
Yujia Dai, Yan Guo, Michael L Curtin, Junling Li, Lori J Pease, Patrick A Marcotte

Bioorg Med Chem Lett· November 2003

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Heterocyclic ketones as inhibitors of histone deacetylase.
Anil Vasudevan, Zhiqin Ji, Robin R Frey, Carol K Wada, Douglas Steinman, Patrick A Marcotte

Bioorg Med Chem Lett· November 2003

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Alpha-keto amides as inhibitors of histone deacetylase.
Carol K Wada, Robin R Frey, Zhiqin Ji, Michael L Curtin, Robert B Garland, Patrick A Marcotte

Bioorg Med Chem Lett· October 2003

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Indole amide hydroxamic acids as potent inhibitors of histone deacetylases.
Yujia Dai, Yan Guo, Jun Guo, Lori J Pease, Junling Li, Patrick A Marcotte

Bioorg Med Chem Lett· June 2003

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