Publications by authors named "Paul Crowe"

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A potent and selective RORγ inhibitor for the treatment of autoimmune diseases.
Taku Ikenogami, Masahiro Yokota, Shingo Fujioka, Naoki Ogawa, Masato Noguchi, Paul Crowe

Bioorg Med Chem Lett· December 2025

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A Concise and Modular Approach to Generate Novel RORγ Agonists.
Shunichi Fukuda, Taku Ikenogami, Kazuki Otake, Shohei Miwa, Katsuya Maeda, Paul Crowe

J Med Chem· August 2025

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Pharmacological Properties of JTE-151; A Novel Orally Available RORγ Antagonist That Suppresses Th17 Cell-Related Responses and .
Kojo Arita, Haiyan Tao, Paul Crowe, Scott Thacher, Sho Otake

Biol Pharm Bull· December 2024

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Discovery and SAR of JTE-151: A Novel RORγ Inhibitor for Clinical Development.
Takaki Maeba, Kazuyuki Hirata, Masayuki Kotoku, Noriyoshi Seki, Katsuya Maeda, Paul Crowe

J Med Chem· January 2024

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Discovery of Second Generation RORγ Inhibitors Composed of an Azole Scaffold.
Masayuki Kotoku, Takaki Maeba, Shingo Fujioka, Masahiro Yokota, Noriyoshi Seki, Paul Crowe

J Med Chem· March 2019

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Ternary crystal structure of human RORγ ligand-binding-domain, an inhibitor and corepressor peptide provides a new insight into corepressor interaction.
Masato Noguchi, Akihiro Nomura, Satoki Doi, Keishi Yamaguchi, Kazuyuki Hirata, Paul Crowe

Sci Rep· November 2018

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Ternary complex of human RORγ ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment.
Masato Noguchi, Akihiro Nomura, Ken Murase, Satoki Doi, Keishi Yamaguchi, Paul Crowe

Genes Cells· June 2017

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Renal Denervation in Patients With Uncontrolled Hypertension and Confirmed Adherence to Antihypertensive Medications.
Mohammed Awais Hameed, Mark Pucci, Una Martin, Richard Watkin, Sagar Doshi, Paul Crowe

J Clin Hypertens (Greenwich)· June 2016

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SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious RORγ Inhibitor.
Kazuyuki Hirata, Masayuki Kotoku, Noriyoshi Seki, Takaki Maeba, Katsuya Maeda, Paul Crowe

ACS Med Chem Lett· January 2016

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Pillars article: A lymphotoxin-B-specific receptor. Science. 1994. 264: 707-710.
Paul D Crowe, Todd L Vanarsdale, Barbara N Walter, Carl F Ware, Catherine Hession

J Immunol· March 2014

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Pelvic congestion syndrome.
Neil Rane, Joe Joseph Leyon, Tracey Littlehales, Arul Ganeshan, Paul Crowe

Curr Probl Diagn Radiol· February 2014

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Restoration of adipose function in obese glucose-tolerant men following pioglitazone treatment is associated with CCAAT enhancer-binding protein β up-regulation.
Lesley A Powell, Paul Crowe, Chenchi Kankara, Jennifer McPeake, David R McCance

Clin Sci (Lond)· August 2012

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Lead optimization of 2-(piperidin-3-yl)-1H-benzimidazoles: identification of 2-morpholin- and 2-thiomorpholin-2-yl-1H-benzimidazoles as selective and CNS penetrating H₁-antihistamines for insomnia.
Satheesh Babu Ravula, Jinghua Yu, Joe A Tran, Melissa Arellano, Fabio C Tucci, Paul D Crowe

Bioorg Med Chem Lett· January 2012

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Influence of pKa on the biotransformation of indene H1-antihistamines by CYP2D6.
Charles Huang, Wilna J Moree, Said Zamani-Kord, Bin-Feng Li, Fabio C Tucci, Paul D Crowe

Bioorg Med Chem Lett· February 2011

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Fresh blood imaging of the peripheral vasculature: an emerging unenhanced MR technique.
Edward T D Hoey, Arul Ganeshan, Rakesh Puni, John Henderson, Paul M Crowe

AJR Am J Roentgenol· December 2010

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Development of a diagnostic genetic test for simplex and autosomal recessive retinitis pigmentosa.
Graeme Richard Clark, Paul Crowe, Dorota Muszynska, Dominic O'Prey, Justin O'Neill

Ophthalmology· November 2010

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Identification of a novel selective H1-antihistamine with optimized pharmacokinetic properties for clinical evaluation in the treatment of insomnia.
Wilna J Moree, Bin-Feng Li, Said Zamani-Kord, Jinghua Yu, Timothy Coon, Paul D Crowe

Bioorg Med Chem Lett· October 2010

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The discovery and structure-activity relationships of 2-(piperidin-3-yl)-1H-benzimidazoles as selective, CNS penetrating H1-antihistamines for insomnia.
Karine Lavrador-Erb, Satheesh Babu Ravula, Jinghua Yu, Said Zamani-Kord, Wilna J Moree, Paul D Crowe

Bioorg Med Chem Lett· May 2010

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Novel benzothiophene H1-antihistamines for the treatment of insomnia.
Wilna J Moree, Florence Jovic, Timothy Coon, Jinghua Yu, Bin-Feng Li, Paul D Crowe

Bioorg Med Chem Lett· April 2010

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Selectivity profiling of novel indene H(1)-antihistamines for the treatment of insomnia.
Bin-Feng Li, Wilna J Moree, Jinghua Yu, Timothy Coon, Said Zamani-Kord, Paul D Crowe

Bioorg Med Chem Lett· April 2010

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Characterization of novel selective H1-antihistamines for clinical evaluation in the treatment of insomnia.
Wilna J Moree, Bin-Feng Li, Florence Jovic, Timothy Coon, Jinghua Yu, Paul D Crowe

J Med Chem· September 2009

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Analytical method for simultaneously measuring ex vivo drug receptor occupancy and dissociation rate: application to (R)-dimethindene occupancy of central histamine H1 receptors.
Siobhan Malany, Lisa M Hernandez, William F Smith, Paul D Crowe, Sam R J Hoare

J Recept Signal Transduct Res· August 2009

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Brain-penetrating 2-aminobenzimidazole H(1)-antihistamines for the treatment of insomnia.
Timothy Coon, Wilna J Moree, Binfeng Li, Jinghua Yu, Said Zamani-Kord, Paul D Crowe

Bioorg Med Chem Lett· August 2009

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A pharmacokinetic evaluation of five H(1) antagonists after an oral and intravenous microdose to human subjects.
Ajay Madan, Zhihong O'Brien, Jianyun Wen, Chris O'Brien, Robert H Farber, Paul Crowe

Br J Clin Pharmacol· March 2009

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Synthesis of A83586C analogs with potent anticancer and beta-catenin/ TCF4/osteopontin inhibitory effects and insights into how A83586C modulates E2Fs and pRb.
Karl J Hale, Soraya Manaviazar, Linos Lazarides, Jonathan George, Marcus A Walters, Paul Crowe

Org Lett· February 2009

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