Publications by authors named "Satoki Doi"

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Fragment-Based Discovery of Novel VE-PTP Inhibitors Using Orthogonal Biophysical Techniques.
Wataru Asano, Kenji Yamanaka, Yasunori Ohara, Toru Uhara, Satoki Doi

Biochemistry· July 2023

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The discovery of 3,3-dimethyl-1,2,3,4-tetrahydroquinoxaline-1-carboxamides as AMPD2 inhibitors with a novel mechanism of action.
Yuki Kitao, Tadataka Saito, Satoshi Watanabe, Yasuhiro Ohe, Koichi Takahashi, Satoki Doi

Bioorg Med Chem Lett· January 2023

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Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors.
Yuki Bessho, Tatsuo Akaki, Yoshinori Hara, Maki Yamakawa, Shingo Obika, Satoki Doi

Bioorg Med Chem· December 2021

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Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases.
Tatsuo Akaki, Yuki Bessho, Takashi Ito, Shingo Fujioka, Minoru Ubukata, Satoki Doi

Bioorg Med Chem· August 2021

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Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders.
Satoru Noji, Yoshinori Hara, Tomoya Miura, Hiroshi Yamanaka, Katsuya Maeda, Satoki Doi

J Med Chem· July 2020

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Discovery of Second Generation RORγ Inhibitors Composed of an Azole Scaffold.
Masayuki Kotoku, Takaki Maeba, Shingo Fujioka, Masahiro Yokota, Noriyoshi Seki, Satoki Doi

J Med Chem· March 2019

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Discovery of a novel azetidine scaffold for colony stimulating factor-1 receptor (CSF-1R) Type II inhibitors by the use of docking models.
Kazutaka Ikegashira, Taku Ikenogami, Takayuki Yamasaki, Yasunori Hase, Takayuki Yamaguchi, Satoki Doi

Bioorg Med Chem Lett· January 2019

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Ternary crystal structure of human RORγ ligand-binding-domain, an inhibitor and corepressor peptide provides a new insight into corepressor interaction.
Masato Noguchi, Akihiro Nomura, Satoki Doi, Keishi Yamaguchi, Kazuyuki Hirata

Sci Rep· November 2018

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Ternary complex of human RORγ ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment.
Masato Noguchi, Akihiro Nomura, Ken Murase, Satoki Doi, Keishi Yamaguchi

Genes Cells· June 2017

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SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious RORγ Inhibitor.
Kazuyuki Hirata, Masayuki Kotoku, Noriyoshi Seki, Takaki Maeba, Katsuya Maeda, Satoki Doi

ACS Med Chem Lett· January 2016

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Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137).
Kazuya Shimura, Eiichi Kodama, Yasuko Sakagami, Yuji Matsuzaki, Wataru Watanabe, Satoki Doi

J Virol· January 2008

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Discovery of conformationally constrained tetracyclic compounds as potent hepatitis C virus NS5B RNA polymerase inhibitors.
Kazutaka Ikegashira, Takahiro Oka, Shintaro Hirashima, Satoru Noji, Hiroshi Yamanaka, Satoki Doi

J Med Chem· November 2006

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