Publications by authors named "Paul Curley"

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Assessment of Favipiravir and Remdesivir in Combination for SARS-CoV-2 Infection in Syrian Golden Hamsters.
Megan Neary, Eduardo Gallardo-Toledo, Joanne Sharp, Joanne Herriott, Edyta Kijak, Paul Curley

Viruses· November 2024

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Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV-2 Delta variant (B.1.617.2) in K18-hACE2 mice using an experimental design reflective of a treatment use case.
Lee Tatham, Anja Kipar, Jo Sharp, Edyta Kijak, Joanne Herriott, Paul Curley

Microbiol Spectr· August 2024

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evaluation of physicochemical-dependent effects of polymeric nanoparticles on their cellular uptake and co-localization using pulmonary calu-3 cell lines.
Nashwa Osman, Paul Curley, Helen Box, Neill Liptrott, Darren Sexton

Drug Dev Ind Pharm· April 2024

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Hyaluronidase impacts exposures of long-acting injectable paliperidone palmitate in rodent models.
Henry Pertinez, Amit Kaushik, Paul Curley, Usman Arshad, Eman El-Khateeb

bioRxiv· March 2024

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Lack of antiviral activity of probenecid in vitro and in Syrian golden hamsters.
Helen J Box, Joanne Sharp, Shaun H Pennington, Edyta Kijak, Lee Tatham, Paul Curley

J Antimicrob Chemother· January 2024

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Chemoprophylactic Assessment of Combined Intranasal SARS-CoV-2 Polymerase and Exonuclease Inhibition in Syrian Golden Hamsters.
Eduardo Gallardo-Toledo, Megan Neary, Joanne Sharp, Joanne Herriott, Edyta Kijak, Paul Curley

Viruses· October 2023

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Quantitation of tizoxanide in multiple matrices to support cell culture, animal and human research.
Megan Neary, Usman Arshad, Lee Tatham, Henry Pertinez, Helen Box, Paul Curley

J Chromatogr B Analyt Technol Biomed Life Sci· August 2023

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Evaluation of Nafamostat as Chemoprophylaxis for SARS-CoV-2 Infection in Hamsters.
Megan Neary, Joanne Sharp, Eduardo Gallardo-Toledo, Joanne Herriott, Edyta Kijak, Paul Curley

Viruses· August 2023

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Preclinical Evaluation of Long-Acting Emtricitabine Semi-Solid Prodrug Nanoparticle Formulations.
Paul Curley, James J Hobson, Neill J Liptrott, Edward Makarov, Amer Al-Khouja

Pharmaceutics· June 2023

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Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV-2 Delta variant (B.1.617.2) in K18-hACE2 mice using an experimental design reflective of a treatment use case.
Lee Tatham, Anja Kipar, Joanne Sharp, Edyta Kijak, Joanne Herriott, Paul Curley

bioRxiv· March 2023

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FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2.
Teresa Brevini, Mailis Maes, Gwilym J Webb, Binu V John, Claudia D Fuchs, Paul Curley

Nature· March 2023

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Lack of antiviral activity of probenecid in Vero E6 cells and Syrian golden hamsters: a need for better understanding of inter-lab differences in preclinical assays.
Helen Box, Shaun H Pennington, Edyta Kijak, Lee Tatham, Claire H Caygill, Paul Curley

bioRxiv· March 2022

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Quantitation of tizoxanide in multiple matrices to support cell culture, animal and human research.
Megan Neary, Usman Arshad, Lee Tatham, Henry Pertinez, Helen Box, Paul Curley

bioRxiv· May 2021

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Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis.
Rajith K R Rajoli, Henry Pertinez, Usman Arshad, Helen Box, Lee Tatham, Paul Curley

Br J Clin Pharmacol· April 2021

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Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection.
James J Hobson, Alison C Savage, Andrew B Dwyer, Catherine Unsworth, Jonathan Massam, Paul Curley

Nanoscale· April 2021

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Development of a highly sensitive bioanalytical assay for the quantification of favipiravir.
Paul Curley, Megan Neary, Usman Arshad, Lee Tatham, Henry Pertinez

bioRxiv· February 2021

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Optimisation and validation of a sensitive bioanalytical method for niclosamide.
Usman Arshad, Henry Pertinez, Helen Box, Lee Tatham, Rajith Kr Rajoli, Paul Curley

bioRxiv· January 2021

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Prioritization of Anti-SARS-Cov-2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics.
Usman Arshad, Henry Pertinez, Helen Box, Lee Tatham, Rajith K R Rajoli, Paul Curley

Clin Pharmacol Ther· October 2020

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Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis.
Rajith Kr Rajoli, Henry Pertinez, Usman Arshad, Helen Box, Lee Tatham, Paul Curley

medRxiv· May 2020

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Anhydrous nanoprecipitation for the preparation of nanodispersions of tenofovir disoproxil fumarate in oils as candidate long-acting injectable depot formulations.
James J Hobson, Paul Curley, Alison C Savage, Amer Al-Khouja, Marco Siccardi

Nanoscale Adv· November 2019

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Predicting Drug-Drug Interactions Between Rifampicin and Long-Acting Cabotegravir and Rilpivirine Using Physiologically Based Pharmacokinetic Modeling.
Rajith K R Rajoli, Paul Curley, Justin Chiong, David Back, Charles Flexner

J Infect Dis· May 2019

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Semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies.
James J Hobson, Amer Al-Khouja, Paul Curley, David Meyers, Charles Flexner

Nat Commun· March 2019

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Inhibitory Effects of Commonly Used Excipients on P-Glycoprotein in Vitro.
Rohan Gurjar, Christina Y S Chan, Paul Curley, Joanne Sharp, Justin Chiong

Mol Pharm· November 2018

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The biological challenges and pharmacological opportunities of orally administered nanomedicine delivery.
Darren Michael Moss, Paul Curley, Hannah Kinvig, Clare Hoskins, Andrew Owen

Expert Rev Gastroenterol Hepatol· March 2018

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Advances in nanomedicine drug delivery applications for HIV therapy.
Paul Curley, Neill J Liptrott, Andrew Owen

Future Sci OA· January 2018

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