Publications by authors named "Paul Gleeson"

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Defining Puberty and Spectrum of Hypogonadism in Alström Syndrome.
Sadaf Ali, Qianwen Zhang, Ijeoma Anwunah, Shanat Baig, Gabriela da Silva Xavier, Paul Gleeson

J Clin Endocrinol Metab· December 2025

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Synthesis of Functionalized Benzo[h]Quinolines via Base-Catalyzed 1,4-Addition/Intramolecular Annulation Cascade.
Wannaporn Disadee, M Paul Gleeson, Somsak Ruchirawat

Chem Asian J· September 2025

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Optimizing the in vitro neuronal microenvironment to mitigate phototoxicity in live-cell imaging.
Cassandra R Hoffmann, Simon Maksour, Jordan E Clarke, Maciej Daniszewski, Fiona J Houghton, Paul A Gleeson

Stem Cell Res Ther· September 2025

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Computationally guided optimization of the antimalarial activity and physicochemical properties of 2,4-diaminopyrimidines.
Guntur Guntur, Duangkamol Gleeson, Mark Anderson, Nicole Mutter, Lauren Webster, M Paul Gleeson

RSC Med Chem· August 2025

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Probing the Effect of Protein and Inhibitor Conformational Flexibility on the Reaction of Rocelitinib-Like Covalent Inhibitors of Epidermal Growth Factor Receptor. A Quantum Mechanics/Molecular Mechanics Study.
Orathai Kaewkham, Duangkamol Gleeson, Poowadon Fukasem, Jirapat Santatiwongchai, Donald J L Jones, M Paul Gleeson

J Chem Inf Model· April 2025

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Organelle perturbation in Alzheimer's disease: do intracellular amyloid-ß and the fragmented Golgi mediate early intracellular neurotoxicity?
Lou Fourriere, Paul A Gleeson

Front Cell Dev Biol· April 2025

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BECLIN-1 is essential for the maintenance of gastrointestinal epithelial integrity by regulating endocytic trafficking, F-actin organization, and lysosomal function.
Juliani Juliani, Sharon Tran, Tiffany J Harris, Peter De Cruz, Sarah L Ellis, Paul A Gleeson

Autophagy Rep· April 2025

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Design, preparation and biological evaluation of new Rociletinib-inspired analogs as irreversible EGFR inhibitors to treat non-small-cell-lung cancer.
Adchata Konsue, Thomanai Lamtha, Duangkamol Gleeson, Donald J L Jones, Robert G Britton, M Paul Gleeson

Bioorg Med Chem· November 2024

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Estimation of the Skin Sensitization Potential of Chemicals of the Acyl Domain Using DFT-Based Calculations.
Pichayapa Limluan, M Paul Gleeson, Duangkamol Gleeson

Chem Res Toxicol· November 2024

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Advances in the cell biology of the trafficking and processing of amyloid precursor protein: impact of familial Alzheimer's disease mutations.
Jingqi Wang, Lou Fourriere, Paul A Gleeson

Biochem J· October 2024

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Comparison of feline and human immunodeficiency virus reverse transcriptase enzymes through chemical screening and computational analysis.
Phanicha Thammajong, Thitinan Aiebchun, Kanokthip Boonyarattanakalin, Duangkamol Gleeson, Nattakarn Pobsuk, M Paul Gleeson

Chem Biol Drug Des· May 2024

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FcRn regulates antigen presentation in dendritic cells downstream of DEC205-targeted vaccines.
Christophe Macri, Matthew Paxman, Devi Jenika, Xiao Peng Lin, Zahra Elahi, Paul A Gleeson

NPJ Vaccines· April 2024

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Spatial-Temporal Mapping Reveals the Golgi as the Major Processing Site for the Pathogenic Swedish APP Mutation: Familial APP Mutant Shifts the Major APP Processing Site.
Jingqi Wang, Paul A Gleeson, Lou Fourriere

Traffic· March 2024

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BECLIN1 is essential for intestinal homeostasis involving autophagy-independent mechanisms through its function in endocytic trafficking.
Sharon Tran, Juliani Juliani, Tiffany J Harris, Marco Evangelista, Julian Ratcliffe, Paul A Gleeson

Commun Biol· February 2024

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Long-term live cell imaging during differentiation of human iPSC-derived neurons.
Jingqi Wang, Paul A Gleeson, Lou Fourriere

STAR Protoc· December 2023

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The new quinazoline derivative (N-methyl-N-[(thiophen-2-yl)methyl]quinazoline-2,4-diamine) vasodilates isolated mesenteric arteries through endothelium-independent mechanisms and has acute hypotensive effects in Wistar rats.
Usana Chatturong, Krongkarn Chootip, Hélène Martin, Maude Tournier-Nappey, Kornkanok Ingkaninan, M Paul Gleeson

Eur J Pharmacol· August 2023

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The endosomal system of primary human vascular endothelial cells and albumin-FcRn trafficking.
Andreas Pannek, Janine Becker-Gotot, Steven K Dower, Anne M Verhagen, Paul A Gleeson

J Cell Sci· August 2023

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Organelle mapping in dendrites of human iPSC-derived neurons reveals dynamic functional dendritic Golgi structures.
Jingqi Wang, Maciej Daniszewski, Marlene M Hao, Damián Hernández, Alice Pébay, Paul A Gleeson

Cell Rep· July 2023

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Arf5-mediated regulation of mTORC1 at the plasma membrane.
Christian Makhoul, Fiona J Houghton, Elizabeth Hinde, Paul A Gleeson

Mol Biol Cell· April 2023

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Quinazoline-based human phosphodiesterase 5 inhibitors exhibited a selective vasorelaxant effect on rat isolated pulmonary arteries involving NO-sGC-cGMP pathway and calcium inhibitory effects.
Usana Chatturong, Hélène Martin, Perle Totoson, Kornkanok Ingkaninan, Prapapan Temkitthawon, M Paul Gleeson

Vascul Pharmacol· December 2022

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A special issue of IUBMB Life celebrating the 50th anniversary of FAOBMB (1972-2022).
Akira Kikuchi, Zengyi Chang, Paul A Gleeson

IUBMB Life· December 2022

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Computational design, synthesis and biological evaluation of PDE5 inhibitors based on N,N-diaminoquinazoline and N,N-diaminopurine scaffolds.
Thanachon Somnarin, Nattakarn Pobsuk, Ruttanaporn Chantakul, Teerapap Panklai, Prapapan Temkitthawon, Duangkamol Gleeson, M Paul Gleeson

Bioorg Med Chem· December 2022

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Quantification of Golgi Entry and Exit Kinetics of Protein Cargoes.
Jingqi Wang, Ellie Hyun-Jung Cho, Paul A Gleeson, Lou Fourriere

Methods Mol Biol· December 2022

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Preparation, biological evaluation and QSAR analysis of urea substituted 2,4-diamino-pyrimidine anti-malarials.
Borvornwat Toviwek, Jennifer Riley, Nicole Mutter, Mark Anderson, Lauren Webster, Duangkamol Gleeson, M Paul Gleeson

RSC Med Chem· December 2022

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Immune tolerance against infused FVIII in hemophilia A is mediated by PD-L1+ Tregs.
Janine Becker-Gotot, Mirjam Meissner, Vadim Kotov, Blanca Jurado-Mestre, Andrea Maione, Paul A Gleeson

J Clin Invest· November 2022

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