Publications by authors named "Paul Kasher"

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Loss of col4a1 in zebrafish recapitulates the cerebrovascular phenotypes associated with monogenic cerebral small vessel disease.
Daisy Flatman, Richard W Naylor, Siobhan Crilly, Isabel Carter, Aleksandr Mironov, Paul R Kasher

Matrix Biol· November 2025

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Continuation of Statins after Acute Intracerebral Haemorrhage and Survival: The Role of Inflammation, Infection, and Indication Bias.
Firas Elfourtia, Joshua Au Yeung, Caroline Drake, Calvin Heal, Nicole Bramhall, Paul Kasher

Cerebrovasc Dis· October 2025

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Association of Angiotensin Inhibitors with Improved Outcome after Acute Intracerebral Hemorrhage: Secondary Analysis of the INTERACT3 Trial.
Adrian R Parry-Jones, Xinwen Ren, Stuart M Allan, Xia Wang, Craig S Anderson, Paul R Kasher

Cerebrovasc Dis· October 2025

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The role of 25-hydroxycholesterol in the pathophysiology of brain vessel dysfunction associated with infection and cholesterol dysregulation.
Victor S Tapia, Sarah E Withers, Ran Zhou, Abigail Bennington, Christopher Hoyle, Paul R Kasher

Dis Model Mech· September 2025

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Reporting of angiographic studies in patients diagnosed with a cerebral arteriovenous malformation: a systematic review.
Suparna Das, Paul Kasher, Mueez Waqar, Adrian Parry-Jones, Hiren Patel

F1000Res· May 2025

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Virtual screening-led design of inhibitor scaffolds for the NLRP3 inflammasome.
Sherihan El-Sayed, Emily McMahon, Sondos Musleh, Sally Freeman, David Brough, Paul R Kasher

Bioorg Chem· December 2024

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Can angiogenesis be reliably determined on digital subtraction angiography in cerebral arteriovenous malformations?
Suparna Das, Helen Raffalli-Ebezant, Paul R Kasher, Adrian Parry-Jones, Hiren C Patel

Br J Neurosurg· November 2024

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Aligning with the 3Rs: alternative models for research into muscle development and inherited myopathies.
Hashir Mehmood, Paul R Kasher, Richard Barrett-Jolley, Gemma L Walmsley

BMC Vet Res· October 2024

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FLT4 causes developmental disorders of the cardiovascular and lymphovascular systems via pleiotropic molecular mechanisms.
Richard M Monaghan, Richard W Naylor, Daisy Flatman, Paul R Kasher, Simon G Williams

Cardiovasc Res· September 2024

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Investigating recovery after a spontaneous intracerebral haemorrhage in zebrafish larvae.
Siobhan Crilly, Isabel Shand, Abigail Bennington, Emily McMahon, Daisy Flatman, Paul R Kasher

Brain Commun· September 2024

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Type I interferon regulates interleukin-1beta and IL-18 production and secretion in human macrophages.
Rodrigo Díaz-Pino, Gillian I Rice, Diego San Felipe, Tamar Pepanashvili, Paul R Kasher

Life Sci Alliance· June 2024

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Brazilin is a natural product inhibitor of the NLRP3 inflammasome.
Emily McMahon, Sherihan El-Sayed, Jack Green, Christopher Hoyle, Lorna FitzPatrick, Paul R Kasher

iScience· February 2024

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Editorial: Innovative models of stroke pathology.
Siobhan Crilly, Marietta Zille, Paul R Kasher, Michel Modo

Front Neurol· August 2023

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Characterization of a mutant zebrafish model implicates dysregulation of cholesterol biosynthesis in Aicardi-Goutières syndrome.
Sarah E Withers, Charlie F Rowlands, Victor S Tapia, Frances Hedley, Ioana-Emilia Mosneag, Paul R Kasher

Front Immunol· April 2023

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Zebrafish for modeling stroke and their applicability for drug discovery and development.
Siobhan Crilly, Emily McMahon, Paul R Kasher

Expert Opin Drug Discov· June 2022

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Zebrafish drug screening identifies candidate therapies for neuroprotection after spontaneous intracerebral haemorrhage.
Siobhan Crilly, Adrian Parry-Jones, Xia Wang, Julian N Selley, James Cook, Paul R Kasher

Dis Model Mech· March 2022

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Dirty Fish Versus Squeaky Clean Mice: Dissecting Interspecies Differences Between Animal Models of Interferonopathy.
Holly A Rutherford, Paul R Kasher, Noémie Hamilton

Front Immunol· June 2021

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RNA-Seq Dataset From Isolated Leukocytes Following Spontaneous Intracerebral Hemorrhage in Zebrafish Larvae.
Siobhan Crilly, James Cooper, Lauren Bradford, Ian E Prise, Siddharth Krishnan, Paul R Kasher

Front Cell Neurosci· April 2021

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Revisiting promising preclinical intracerebral hemorrhage studies to highlight repurposable drugs for translation.
Siobhan Crilly, Sarah E Withers, Stuart M Allan, Adrian R Parry-Jones, Paul R Kasher

Int J Stroke· February 2021

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Identification of a Variant in a Family With Arrhythmogenic Cardiomyopathy and Left Ventricular Fibrosis.
Timothy F Spracklen, Paul R Kasher, Sarah Kraus, Tarryn L Botha, Donna J Page

Circ Genom Precis Med· February 2021

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Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine.
Víctor Faundes, Martin D Jennings, Siobhan Crilly, Sarah Legraie, Sarah E Withers, Paul R Kasher

Nat Commun· February 2021

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A Multi-Model Pipeline for Translational Intracerebral Haemorrhage Research.
Sarah E Withers, Adrian R Parry-Jones, Stuart M Allan, Paul R Kasher

Transl Stroke Res· December 2020

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Analysis of U8 snoRNA Variants in Zebrafish Reveals How Bi-allelic Variants Cause Leukoencephalopathy with Calcifications and Cysts.
Andrew P Badrock, Carolina Uggenti, Ludivine Wacheul, Siobhan Crilly, Emma M Jenkinson, Paul R Kasher

Am J Hum Genet· May 2020

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Using Zebrafish Larvae to Study the Pathological Consequences of Hemorrhagic Stroke.
Siobhan Crilly, Alexandra Njegic, Adrian R Parry-Jones, Stuart M Allan, Paul R Kasher

J Vis Exp· June 2019

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Using zebrafish larval models to study brain injury, locomotor and neuroinflammatory outcomes following intracerebral haemorrhage.
Siobhan Crilly, Alexandra Njegic, Sarah E Laurie, Elisavet Fotiou, Georgina Hudson, Paul R Kasher

F1000Res· October 2018

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