Publications by authors named "Paul Mercer"

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Transcriptome analysis of IPF fibroblastic foci identifies key pathways involved in fibrogenesis.
Delphine Guillotin, Adam R Taylor, Manuela Platé, Paul F Mercer, Lindsay M Edwards

Thorax· January 2021

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Author Correction: The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis.
Hannah V Woodcock, Jessica D Eley, Delphine Guillotin, Manuela Platé, Carmel B Nanthakumar, Paul F Mercer

Nat Commun· September 2020

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Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis.
Alison E John, Rebecca H Graves, K Tao Pun, Giovanni Vitulli, Ellen J Forty, Paul F Mercer

Nat Commun· September 2020

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The circadian clock protein REVERBα inhibits pulmonary fibrosis development.
Peter S Cunningham, Peter Meijer, Alicja Nazgiewicz, Simon G Anderson, Lee A Borthwick, Paul F Mercer

Proc Natl Acad Sci U S A· January 2020

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mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β-induced collagen biosynthesis.
Brintha Selvarajah, Ilan Azuelos, Manuela Platé, Delphine Guillotin, Ellen J Forty, Paul F Mercer

Sci Signal· May 2019

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A randomised, placebo-controlled study of omipalisib (PI3K/mTOR) in idiopathic pulmonary fibrosis.
Pauline T Lukey, Stephen A Harrison, Shuying Yang, Yim Man, Beverley F Holman, Paul F Mercer

Eur Respir J· March 2019

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The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis.
Hannah V Woodcock, Jessica D Eley, Delphine Guillotin, Manuela Platé, Carmel B Nanthakumar, Paul F Mercer

Nat Commun· January 2019

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Evidence for chemokine synergy during neutrophil migration in ARDS.
Andrew E Williams, Ricardo J José, Paul F Mercer, David Brealey, Dhruv Parekh

Thorax· January 2017

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Innate immune signaling and stem cell renewal in idiopathic pulmonary fibrosis.
Paul F Mercer, Rachel C Chambers

Nat Med· November 2016

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Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF.
Paul F Mercer, Hannah V Woodcock, Jessica D Eley, Manuela Platé, Michal G Sulikowski

Thorax· August 2016

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A valuable tool for optimising design.
Paul Mercer

Health Estate· October 2015

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The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection.
Natalia Smoktunowicz, Robert E Alexander, Linda Franklin, Andrew E Williams, Beverley Holman, Paul F Mercer

Dis Model Mech· September 2015

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Regulation of neutrophilic inflammation by proteinase-activated receptor 1 during bacterial pulmonary infection.
Ricardo J José, Andrew E Williams, Paul F Mercer, Michal G Sulikowski, Jeremy S Brown

J Immunol· June 2015

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Dorothy Helena Herbert AM, BSc, MB BS, DObstRCOG.
Anthony R Herbert, Paul J Mercer, Rev Ronald W Herbert

Med J Aust· April 2015

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Mechanisms of alveolar epithelial injury, repair, and fibrosis.
Rachel C Chambers, Paul F Mercer

Ann Am Thorac Soc· March 2015

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Translational models of lung disease.
Paul F Mercer, Katharine Abbott-Banner, Ian M Adcock, Richard G Knowles

Clin Sci (Lond)· February 2015

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Proteinase-activated receptor-1, CCL2, and CCL7 regulate acute neutrophilic lung inflammation.
Paul F Mercer, Andrew E Williams, Christopher J Scotton, Ricardo J José, Michal Sulikowski

Am J Respir Cell Mol Biol· January 2014

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Ex vivo micro-computed tomography analysis of bleomycin-induced lung fibrosis for preclinical drug evaluation.
Chris J Scotton, Brian Hayes, Robert Alexander, Arnab Datta, Ellen J Forty, Paul F Mercer

Eur Respir J· December 2013

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Coagulation and coagulation signalling in fibrosis.
Paul F Mercer, Rachel C Chambers

Biochim Biophys Acta· July 2013

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New tale for an old fox in IPF?
Paul F Mercer, Rachel C Chambers

Am J Physiol Lung Cell Mol Physiol· April 2013

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PAR-1-dependent and PAR-independent pro-inflammatory signaling in human lung fibroblasts exposed to thrombin.
Alejandro Ortiz-Stern, Xiaoling Deng, Natalia Smoktunowicz, Paul F Mercer, Rachel C Chambers

J Cell Physiol· November 2012

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Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis.
Emmet E McGrath, Allan Lawrie, Helen M Marriott, Paul Mercer, Simon S Cross

Thorax· September 2012

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Diminished prostaglandin E2 contributes to the apoptosis paradox in idiopathic pulmonary fibrosis.
Toby M Maher, Iona C Evans, Stephen E Bottoms, Paul F Mercer, Andrew J Thorley

Am J Respir Crit Care Med· July 2010

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Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury.
Chris J Scotton, Malvina A Krupiczojc, Melanie Königshoff, Paul F Mercer, Y C Gary Lee

J Clin Invest· September 2009

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Pulmonary epithelium is a prominent source of proteinase-activated receptor-1-inducible CCL2 in pulmonary fibrosis.
Paul F Mercer, Robin H Johns, Chris J Scotton, Malvina A Krupiczojc, Melanie Königshoff

Am J Respir Crit Care Med· March 2009

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