Publications by authors named "Paul Newcombe"

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Optimal risk-assessment scheduling for primary prevention of cardiovascular disease.
Francesca Gasperoni, Christopher H Jackson, Angela M Wood, Michael J Sweeting, Paul J Newcombe

J R Stat Soc Ser A Stat Soc· July 2025

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Circumstances surrounding alcohol toxicity deaths and prior pharmacotherapy for alcohol use disorder in Ontario, Canada.
William Wynne, Anita Iacono, Joanna Yang, Bisola Hamzat, Pamela Leece, Paul Newcombe

Alcohol Alcohol· July 2025

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The changing role of substances: trends, characteristics of individuals and prior healthcare utilization among individuals with accidental substance-related toxicity deaths in Ontario Canada.
Shaleesa Ledlie, Alice Holton, Pamela Leece, Bisola Hamzat, Joanna Yang, Paul Newcombe

PLoS One· May 2025

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Hierarchical joint analysis of marginal summary statistics-Part I: Multipopulation fine mapping and credible set construction.
Jiayi Shen, Lai Jiang, Kan Wang, Anqi Wang, Fei Chen, Paul J Newcombe

Genet Epidemiol· September 2024

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Type I interferon blockade with anifrolumab in patients with systemic lupus erythematosus modulates key immunopathological pathways in a gene expression and proteomic analysis of two phase 3 trials.
Tina Baker, Hoda Sharifian, Paul J Newcombe, Patrick G Gavin, Mark N Lazarus

Ann Rheum Dis· July 2024

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A Randomized Phase I Study of the Anti-Interleukin-33 Antibody Tozorakimab in Healthy Adults and Patients With Chronic Obstructive Pulmonary Disease.
Fred Reid, Dave Singh, Muna Albayaty, Rachel Moate, Eulalia Jimenez, Paul Newcombe

Clin Pharmacol Ther· March 2024

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Conditional inference in cis-Mendelian randomization using weak genetic factors.
Ashish Patel, Dipender Gill, Paul Newcombe, Stephen Burgess

Biometrics· December 2023

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Statistical methods for cis-Mendelian randomization with two-sample summary-level data.
Apostolos Gkatzionis, Stephen Burgess, Paul J Newcombe

Genet Epidemiol· February 2023

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Tailored Bayes: a risk modeling framework under unequal misclassification costs.
Solon Karapanagiotis, Umberto Benedetto, Sach Mukherjee, Paul D W Kirk, Paul J Newcombe

Biostatistics· December 2022

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Two-stage penalized regression screening to detect biomarker-treatment interactions in randomized clinical trials.
Jixiong Wang, Ashish Patel, James M S Wason, Paul J Newcombe

Biometrics· March 2022

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Bayesian variable selection with a pleiotropic loss function in Mendelian randomization.
Apostolos Gkatzionis, Stephen Burgess, David V Conti, Paul J Newcombe

Stat Med· October 2021

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A Hierarchical Approach Using Marginal Summary Statistics for Multiple Intermediates in a Mendelian Randomization or Transcriptome Analysis.
Lai Jiang, Shujing Xu, Nicholas Mancuso, Paul J Newcombe, David V Conti

Am J Epidemiol· June 2021

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In Severe Alcoholic Hepatitis, Serum Keratin-18 Fragments Are Diagnostic, Prognostic, and Theragnostic Biomarkers.
Stephen R Atkinson, Jane I Grove, Stephanie Liebig, Stuart Astbury, Nikhil Vergis, Paul Newcombe

Am J Gastroenterol· November 2020

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A flexible and parallelizable approach to genome-wide polygenic risk scores.
Paul J Newcombe, Christopher P Nelson, Nilesh J Samani, Frank Dudbridge

Genet Epidemiol· October 2019

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Fine mapping chromatin contacts in capture Hi-C data.
Christiaan Q Eijsbouts, Oliver S Burren, Paul J Newcombe, Chris Wallace

BMC Genomics· January 2019

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Treading carefully.
Alex Mermikides, Sally Richardson, Terry Firth, Paul Newcombe, Karen Norman

Br J Nurs· July 2018

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Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.
Tokhir Dadaev, Edward J Saunders, Paul J Newcombe, Ezequiel Anokian, Daniel A Leongamornlert

Nat Commun· June 2018

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Development and External Validation of Prediction Models for 10-Year Survival of Invasive Breast Cancer. Comparison with PREDICT and CancerMath.
Solon Karapanagiotis, Paul D P Pharoah, Christopher H Jackson, Paul J Newcombe

Clin Cancer Res· May 2018

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Accuracy of Gene Scores when Pruning Markers by Linkage Disequilibrium.
Frank Dudbridge, Paul J Newcombe

Hum Hered· October 2017

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Homozygous p.Ser267Phe in SLC10A1 is associated with a new type of hypercholanemia and implications for personalized medicine.
Ruihong Liu, Chuming Chen, Xuefeng Xia, Qijun Liao, Qiong Wang, Paul J Newcombe

Sci Rep· August 2017

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JAM: A Scalable Bayesian Framework for Joint Analysis of Marginal SNP Effects.
Paul J Newcombe, David V Conti, Sylvia Richardson

Genet Epidemiol· April 2016

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Insight into Genotype-Phenotype Associations through eQTL Mapping in Multiple Cell Types in Health and Immune-Mediated Disease.
James E Peters, Paul A Lyons, James C Lee, Arianne C Richard, Mary D Fortune, Paul J Newcombe

PLoS Genet· March 2016

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Students' first year experience of a BSc (Hons) in nursing: a pilot study.
Julia Gale, Ann Ooms, Paul Newcombe, Di Marks-Maran

Nurse Educ Today· January 2015

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GUESS-ing polygenic associations with multiple phenotypes using a GPU-based evolutionary stochastic search algorithm.
Leonardo Bottolo, Marc Chadeau-Hyam, David I Hastie, Tanja Zeller, Benoit Liquet, Paul Newcombe

PLoS Genet· March 2014

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Genetic factors associated with response to intravitreal ranibizumab in Korean patients with neovascular age-related macular degeneration.
Un Chul Park, Joo Young Shin, Sang Jin Kim, Eun Soon Shin, Jong Eun Lee, Paul J Newcombe

Retina· February 2014

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