Publications by authors named "Paul Stetsko"

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Pharmacodynamics-based approach for efficacious human dose projection of BMS-986260, a small molecule transforming growth factor beta receptor 1 inhibitor.
Karen E Parrish, Jesse Swanson, Lihong Cheng, Emily Luk, Paul Stetsko

Biopharm Drug Dispos· April 2021

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Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212).
Donald J P Pinto, Michael J Orwat, Leon M Smith, Mimi L Quan, Patrick Y S Lam, Paul Stetsko

J Med Chem· December 2017

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Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies.
Pratik Devasthale, Wei Wang, James Mignone, Kishore Renduchintala, Sridhar Radhakrishnan, Paul Stetsko

Bioorg Med Chem Lett· October 2015

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Investigation of a Degradant in a Biologics Formulation Buffer Containing L-Histidine.
Chunlei Wang, Aaron Yamniuk, Jun Dai, Sike Chen, Paul Stetsko

Pharm Res· August 2015

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Dihydropyrrolopyrazol-6-one MCHR1 antagonists for the treatment of obesity: Insights on in vivo efficacy from a novel FLIPR assay setup.
Pratik Devasthale, Wei Wang, Andres S Hernandez, Fang Moore, Kishore Renduchintala, Paul Stetsko

Bioorg Med Chem Lett· July 2015

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Identification of a nonbasic melanin hormone receptor 1 antagonist as an antiobesity clinical candidate.
William N Washburn, Mark Manfredi, Pratik Devasthale, Guohua Zhao, Saleem Ahmad, Paul Stetsko

J Med Chem· September 2014

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Reductions in log P improved protein binding and clearance predictions enabling the prospective design of cannabinoid receptor (CB1) antagonists with desired pharmacokinetic properties.
Bruce A Ellsworth, Philip M Sher, Ximao Wu, Gang Wu, Richard B Sulsky, Paul I Stetsko

J Med Chem· December 2013

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Application of a kosmotrope-based solubility assay to multiple protein therapeutic classes indicates broad use as a high-throughput screen for protein therapeutic aggregation propensity.
Aaron P Yamniuk, Noah Ditto, Mehul Patel, Jun Dai, Preeti Sejwal, Paul Stetsko

J Pharm Sci· August 2013

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Estimation of the extent of in vivo formation of a mutagenic aromatic amine from a potent thyromimetic compound: correlation of in vitro and in vivo findings.
Kamelia Behnia, Georgia Cornelius, Jian Wang, Petia Shipkova, Susan Johnghar, Paul Stetsko

Chem Res Toxicol· June 2011

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A rabbit model for sublingual drug delivery: comparison with human pharmacokinetic studies of propranolol, verapamil and captopril.
Manisha M Dali, Paul A Moench, Neil R Mathias, Paul I Stetsko, Christopher L Heran

J Pharm Sci· January 2006

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The effect of anesthesia on the pharmacokinetics of sublingually administered verapamil in rabbits.
Paul A Moench, Christopher L Heran, Paul I Stetsko, Neil R Mathias, Doris A Wall

J Pharm Sci· September 2003

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Permeability characteristics of calu-3 human bronchial epithelial cells: in vitro-in vivo correlation to predict lung absorption in rats.
Neil R Mathia, Julita Timoszyk, Paul I Stetsko, John R Megill, Ronald L Smith

J Drug Target· February 2002

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