Publications by authors named "Paul Tempest"

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Correction to: Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607.
Yang Shi, Alexey G Murzin, Benjamin Falcon, Alexander Epstein, Jonathan Machin, Paul Tempest

Acta Neuropathol· June 2021

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Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607.
Yang Shi, Alexey G Murzin, Benjamin Falcon, Alexander Epstein, Jonathan Machin, Paul Tempest

Acta Neuropathol· May 2021

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Use of molecular modeling aided design to dial out hERG liability in adenosine A(2A) receptor antagonists.
Qiaolin Deng, Yeon-Hee Lim, Rajan Anand, Younong Yu, Jae-hun Kim, Paul Tempest

Bioorg Med Chem Lett· August 2015

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Thiophene carboxamide inhibitors of JAK2 as potential treatments for myleoproliferative neoplasms.
Andrew M Haidle, Anna A Zabierek, Kaleen K Childers, Craig Rosenstein, Anjili Mathur, Paul Tempest

Bioorg Med Chem Lett· April 2014

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Lead optimization of 4,4-biaryl piperidine amides as γ-secretase inhibitors.
Joshua Close, Richard Heidebrecht, John Hendrix, Chaomin Li, Ben Munoz, Paul Tempest

Bioorg Med Chem Lett· May 2012

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Parallel medicinal chemistry approaches to selective HDAC1/HDAC2 inhibitor (SHI-1:2) optimization.
Solomon D Kattar, Laura M Surdi, Anna Zabierek, Joey L Methot, Richard E Middleton, Paul Tempest

Bioorg Med Chem Lett· February 2009

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Design of novel histone deacetylase inhibitors.
Phieng Siliphaivanh, Paul Harrington, David J Witter, Karin Otte, Paul Tempest

Bioorg Med Chem Lett· August 2007

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Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor.
Brian L Hodous, Stephanie D Geuns-Meyer, Paul E Hughes, Brian K Albrecht, Steve Bellon, Paul Tempest

J Med Chem· February 2007

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Solid-phase synthesis and structure-activity relationships of novel biarylethers as melanin-concentrating hormone receptor-1 antagonists.
Vu Ma, Anthony W Bannon, Jamie Baumgartner, Clarence Hale, Faye Hsieh, Paul Tempest

Bioorg Med Chem Lett· October 2006

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Recent advances in heterocycle generation using the efficient Ugi multiple-component condensation reaction.
Paul A Tempest

Curr Opin Drug Discov Devel· November 2005

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Library generation via postcondensation modifications of isocyanide-based multicomponent reactions.
Christopher Hulme, Hugues Bienaymé, Thomas Nixey, Balan Chenera, Wyeth Jones, Paul Tempest

Methods Enzymol· February 2004

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