Publications by authors named "Pavel Savechenkov"

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Discovery of Pyrazolopyrazines as Selective, Potent, and Mutant-Active MET Inhibitors with Intracranial Efficacy.
Quinn A Bumpers, Robert W Pipal, Anna M Benz-Weeden, James T Brewster, Adam Cook, Pavel Savechenkov

J Med Chem· August 2024

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Identification of the Clinical Development Candidate , a Covalent KRAS Inhibitor for the Treatment of Cancer.
Jay B Fell, John P Fischer, Brian R Baer, James F Blake, Karyn Bouhana, Pavel Savechenkov

J Med Chem· July 2020

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Binding site location on GABA receptors determines whether mixtures of intravenous general anaesthetics interact synergistically or additively in vivo.
Daniel E Kent, Pavel Y Savechenkov, Karol S Bruzik, Keith W Miller

Br J Pharmacol· December 2019

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Identifying Drugs that Bind Selectively to Intersubunit General Anesthetic Sites in the 132 GABAR Transmembrane Domain.
Selwyn S Jayakar, Xiaojuan Zhou, David C Chiara, Carlos Jarava-Barrera, Pavel Y Savechenkov

Mol Pharmacol· June 2019

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A photoreactive analog of allopregnanolone enables identification of steroid-binding sites in a nicotinic acetylcholine receptor.
Zhiyi Yu, David C Chiara, Pavel Y Savechenkov, Karol S Bruzik, Jonathan B Cohen

J Biol Chem· May 2019

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Inhibitable photolabeling by neurosteroid diazirine analog in the β3-Subunit of human hetereopentameric type A GABA receptors.
Bo Wu, Selwyn S Jayakar, Xiaojuan Zhou, Katherine Titterton, David C Chiara, Pavel Y Savechenkov

Eur J Med Chem· January 2019

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Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity.
Jay B Fell, John P Fischer, Brian R Baer, Joshua Ballard, James F Blake, Pavel Savechenkov

ACS Med Chem Lett· December 2018

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Anion Sensing by Fluorescent Expanded Calixpyrroles.
Mariia Pushina, Petr Koutnik, Ryuhei Nishiyabu, Tsuyoshi Minami, Pavel Savechenkov

Chemistry· April 2018

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Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands.
Pavel Y Savechenkov, David C Chiara, Rooma Desai, Alexander T Stern, Xiaojuan Zhou

Eur J Med Chem· August 2017

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General Anesthetic Binding Sites in Human α4β3δ γ-Aminobutyric Acid Type A Receptors (GABAARs).
David C Chiara, Youssef Jounaidi, Xiaojuan Zhou, Pavel Y Savechenkov, Karol S Bruzik

J Biol Chem· December 2016

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Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1 β3 γ2L GABAA receptor account for their in vivo effects.
Rooma Desai, Pavel Y Savechenkov, Dorota Zolkowska, Ri Le Ge, Michael A Rogawski

J Physiol· November 2015

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Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the γ+-β- Interface.
Selwyn S Jayakar, Xiaojuan Zhou, Pavel Y Savechenkov, David C Chiara, Rooma Desai

J Biol Chem· September 2015

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Multiple propofol-binding sites in a γ-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog.
Selwyn S Jayakar, Xiaojuan Zhou, David C Chiara, Zuzana Dostalova, Pavel Y Savechenkov

J Biol Chem· October 2014

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Identifying barbiturate binding sites in a nicotinic acetylcholine receptor with [3H]allyl m-trifluoromethyldiazirine mephobarbital, a photoreactive barbiturate.
Ayman K Hamouda, Deirdre S Stewart, David C Chiara, Pavel Y Savechenkov, Karol S Bruzik

Mol Pharmacol· May 2014

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Anion binding modes in meso-substituted hexapyrrolic calix[4]pyrrole isomers.
Kai-Chi Chang, Tsuyoshi Minami, Petr Koutnik, Pavel Y Savechenkov, Yuanli Liu

J Am Chem Soc· January 2014

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Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor.
David C Chiara, Selwyn S Jayakar, Xiaojuan Zhou, Xi Zhang, Pavel Y Savechenkov

J Biol Chem· July 2013

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Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic.
Pavel Y Savechenkov, Xi Zhang, David C Chiara, Deirdre S Stewart, Rile Ge

J Med Chem· July 2012

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p-(4-Azipentyl)propofol: a potent photoreactive general anesthetic derivative of propofol.
Deirdre S Stewart, Pavel Y Savechenkov, Zuzana Dostalova, David C Chiara, Rile Ge

J Med Chem· December 2011

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