Publications by authors named "Pawel A Osmulski"

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CTC1-STN1-TEN1 controls DNA break repair pathway choice via DNA end resection blockade.
Cody M Rogers, Hardeep Kaur, Michelle L Swift, Vivek B Raina, Shuo Zhou, Pawel A Osmulski

Science· May 2025

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Proteasome Augmentation Mitigates Age-Related Cognitive Decline in Mice.
Danitra Parker, Kanisa Davidson, Pawel A Osmulski, Maria Gaczynska, Andrew M Pickering

Aging Cell· March 2025

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PAI-1 uncouples integrin-β1 from restrain by membrane-bound β-catenin to promote collagen fibril remodeling in obesity-related neoplasms.
Li-Ling Lin, Bijaya Nayak, Pawel A Osmulski, Exing Wang, Chen-Pin Wang

Cell Rep· August 2024

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Ex vivo drug testing of patient-derived lung organoids to predict treatment responses for personalized medicine.
Josephine A Taverna, Chia-Nung Hung, Madison Williams, Ryan Williams, Meizhen Chen, Pawel A Osmulski

Lung Cancer· April 2024

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Phagocytosis-initiated tumor hybrid cells acquire a c-Myc-mediated quasi-polarization state for immunoevasion and distant dissemination.
Chih-Wei Chou, Chia-Nung Hung, Cheryl Hsiang-Ling Chiu, Xi Tan, Meizhen Chen, Pawel A Osmulski

Nat Commun· October 2023

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AXL-initiated paracrine activation of pSTAT3 enhances mesenchymal and vasculogenic supportive features of tumor-associated macrophages.
Chia-Nung Hung, Meizhen Chen, Daniel T DeArmond, Cheryl H-L Chiu, Catherine A Limboy, Pawel A Osmulski

Cell Rep· September 2023

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Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy.
Stacy A Hussong, Andy Q Banh, Candice E Van Skike, Angela O Dorigatti, Stephen F Hernandez, Pawel A Osmulski

Nat Commun· April 2023

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Electronic Circular Dichroism Detects Conformational Changes Associated with Proteasome Gating Confirmed Using AFM Imaging.
Alessandro D'Urso, Roberto Purrello, Alessandra Cunsolo, Danilo Milardi, Caterina Fattorusso, Pawel A Osmulski

Biomolecules· April 2023

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A Role for the Proteasome Alpha2 Subunit N-Tail in Substrate Processing.
Indrajit Sahu, Monika Bajorek, Xiaolin Tan, Madabhushi Srividya, Daria Krutauz, Pawel A Osmulski

Biomolecules· March 2023

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Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer's-like pathology in mouse and fly APP overexpression models.
E Sandra Chocron, Erin Munkácsy, Harper S Kim, Przemyslaw Karpowicz, Nisi Jiang, Pawel A Osmulski

Sci Adv· June 2022

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Contacts with Macrophages Promote an Aggressive Nanomechanical Phenotype of Circulating Tumor Cells in Prostate Cancer.
Pawel A Osmulski, Alessandra Cunsolo, Meizhen Chen, Yusheng Qian, Chun-Lin Lin

Cancer Res· August 2021

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Single-Cell Proteomic Profiling Identifies Combined AXL and JAK1 Inhibition as a Novel Therapeutic Strategy for Lung Cancer.
Josephine A Taverna, Chia-Nung Hung, Daniel T DeArmond, Meizhen Chen, Chun-Lin Lin, Pawel A Osmulski

Cancer Res· April 2020

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New Peptide-Based Pharmacophore Activates 20S Proteasome.
Paweł A Osmulski, Przemysław Karpowicz, Elżbieta Jankowska, Jonathan Bohmann, Andrew M Pickering

Molecules· March 2020

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Inhibitory Interplay of SULT2B1b Sulfotransferase with AKR1C3 Aldo-keto Reductase in Prostate Cancer.
Sulgi Park, Chung-Seog Song, Chun-Lin Lin, Shoulei Jiang, Pawel A Osmulski

Endocrinology· February 2020

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Targeting Protein-Protein Interactions in the Ubiquitin-Proteasome Pathway.
Maria Gaczynska, Pawel A Osmulski

Adv Protein Chem Struct Biol· June 2019

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Pipecolic esters as minimized templates for proteasome inhibition.
Matthew B Giletto, Pawel A Osmulski, Corey L Jones, Maria E Gaczynska, Jetze J Tepe

Org Biomol Chem· March 2019

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Small Molecule Modulation of Proteasome Assembly.
Evert Njomen, Pawel A Osmulski, Corey L Jones, Maria Gaczynska, Jetze J Tepe

Biochemistry· July 2018

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TGF-β signal rewiring sustains epithelial-mesenchymal transition of circulating tumor cells in prostate cancer xenograft hosts.
Guangcun Huang, Pawel A Osmulski, Hakim Bouamar, Devalingam Mahalingam, Chun-Lin Lin

Oncotarget· November 2016

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AFM Imaging Reveals Topographic Diversity of Wild Type and Z Variant Polymers of Human α1-Proteinase Inhibitor.
Maria Gaczynska, Przemyslaw Karpowicz, Christine E Stuart, Malgorzata G Norton, Jeffrey H Teckman, Pawel A Osmulski

PLoS One· August 2016

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Interplay between Structure and Charge as a Key to Allosteric Modulation of Human 20S Proteasome by the Basic Fragment of HIV-1 Tat Protein.
Przemysław Karpowicz, Paweł A Osmulski, Julia Witkowska, Emilia Sikorska, Małgorzata Giżyńska

PLoS One· June 2016

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Targeting Protein-Protein Interactions in the Proteasome Super-Assemblies.
Maria Gaczynska, Pawel A Osmulski

Curr Top Med Chem· April 2016

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Harnessing proteasome dynamics and allostery in drug design.
Maria Gaczynska, Pawel A Osmulski

Antioxid Redox Signal· December 2014

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A cytosolic protein factor from the naked mole-rat activates proteasomes of other species and protects these from inhibition.
Karl A Rodriguez, Pawel A Osmulski, Anson Pierce, Susan T Weintraub, Maria Gaczynska

Biochim Biophys Acta· November 2014

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Dissecting a role of a charge and conformation of Tat2 peptide in allosteric regulation of 20S proteasome.
Julia Witkowska, Przemysław Karpowicz, Maria Gaczynska, Pawel A Osmulski, Elżbieta Jankowska

J Pept Sci· August 2014

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Rapamycin allosterically inhibits the proteasome.
Pawel A Osmulski, Maria Gaczynska

Mol Pharmacol· July 2013

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