Publications by authors named "Evert Njomen"

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Cysteine allostery and autoinhibition govern human STING oligomer functionality.
Rebecca Chan, Xujun Cao, Sabrina L Ergun, Evert Njomen, Stephen R Lynch

Nat Chem Biol· October 2025

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Tryptoline Stereoprobe Elaboration Identifies Inhibitors of the GRPEL1-HSPA9 Chaperone Complex.
Rachel E Hayward, Raymond F Berkeley, Zijian Gao, Maximilian Garhammer, Marc A Morizono, Evert Njomen

bioRxiv· October 2025

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Chemical tools to expand the ligandable proteome: Diversity-oriented synthesis-based photoreactive stereoprobes.
Daisuke Ogasawara, David B Konrad, Zher Yin Tan, Kimberly L Carey, Jessica Luo, Evert Njomen

Cell Chem Biol· December 2024

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Redirecting the pioneering function of FOXA1 with covalent small molecules.
Sang Joon Won, Yuxiang Zhang, Christopher J Reinhardt, Lauren M Hargis, Nicole S MacRae, Evert Njomen

Mol Cell· November 2024

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Multi-tiered chemical proteomic maps of tryptoline acrylamide-protein interactions in cancer cells.
Evert Njomen, Rachel E Hayward, Kristen E DeMeester, Daisuke Ogasawara, Melissa M Dix

Nat Chem· October 2024

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Proteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders.
Zhonglin Liu, Jarrett R Remsberg, Haoxin Li, Evert Njomen, Kristen E DeMeester

J Am Chem Soc· April 2024

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Redirecting the pioneering function of FOXA1 with covalent small molecules.
Sang Joon Won, Yuxiang Zhang, Christopher J Reinhardt, Nicole S MacRae, Kristen E DeMeester, Evert Njomen

bioRxiv· March 2024

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Covalent Targeting As a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly.
Caroline Stanton, Jie Sun, Kayla Nutsch, Jessica D Rosarda, Thu Nguyen, Evert Njomen

ACS Chem Biol· February 2024

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Chemical tools to expand the ligandable proteome: diversity-oriented synthesis-based photoreactive stereoprobes.
Daisuke Ogasawara, David B Konrad, Zher Yin Tan, Kimberly L Carey, Jessica Luo, Evert Njomen

bioRxiv· February 2024

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Chemical Proteomic Discovery of Isotype-Selective Covalent Inhibitors of the RNA Methyltransferase NSUN2.
Yongfeng Tao, Jan G Felber, Zhongyu Zou, Evert Njomen, Jarrett R Remsberg

Angew Chem Int Ed Engl· December 2023

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Assigning functionality to cysteines by base editing of cancer dependency genes.
Haoxin Li, Tiantai Ma, Jarrett R Remsberg, Sang Joon Won, Kristen E DeMeester, Evert Njomen

Nat Chem Biol· November 2023

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Proteomic discovery of chemical probes that perturb protein complexes in human cells.
Michael R Lazear, Jarrett R Remsberg, Martin G Jaeger, Katherine Rothamel, Hsuan-Lin Her, Evert Njomen

Mol Cell· May 2023

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Development of a Cell-Based AlphaLISA Assay for High-Throughput Screening for Small Molecule Proteasome Modulators.
Sophia D Staerz, Erika M Lisabeth, Evert Njomen, Thomas S Dexheimer, Richard R Neubig

ACS Omega· May 2023

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Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain.
Hannah C Feldman, Elisa Merlini, Carlos Guijas, Kristen E DeMeester, Evert Njomen

Proc Natl Acad Sci U S A· August 2022

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Small Molecule 20S Proteasome Enhancer Regulates MYC Protein Stability and Exhibits Antitumor Activity in Multiple Myeloma.
Evert Njomen, Allison Vanecek, Theresa A Lansdell, Ya-Ting Yang, Peter Z Schall

Biomedicines· April 2022

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Regulation of Autophagic Flux by the 20S Proteasome.
Evert Njomen, Jetze J Tepe

Cell Chem Biol· September 2019

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Proteasome Activation as a New Therapeutic Approach To Target Proteotoxic Disorders.
Evert Njomen, Jetze J Tepe

J Med Chem· July 2019

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Small Molecule Modulation of Proteasome Assembly.
Evert Njomen, Pawel A Osmulski, Corey L Jones, Maria Gaczynska, Jetze J Tepe

Biochemistry· July 2018

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Small Molecule Enhancement of 20S Proteasome Activity Targets Intrinsically Disordered Proteins.
Corey L Jones, Evert Njomen, Benita Sjögren, Thomas S Dexheimer, Jetze J Tepe

ACS Chem Biol· September 2017

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Humanin Peptide Binds to Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3) and Regulates Its Interaction with Importin-β.
Evert Njomen, Hedeel G Evans, Samanthi H Gedara, Deborah L Heyl

Protein Pept Lett· May 2016

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