Publications by authors named "Per Plenge"

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Dynamic extracellular vestibule of human SERT: Unveiling druggable potential with high-affinity allosteric inhibitors.
Kristine Salomon, Ara M Abramyan, Per Plenge, Lingle Wang, Christoffer Bundgaard

Proc Natl Acad Sci U S A· October 2023

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The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter.
Per Plenge, Dongxue Yang, Kristine Salomon, Louise Laursen, Iris E Kalenderoglou

Nat Commun· August 2021

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The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter.
Per Plenge, Ara M Abramyan, Gunnar Sørensen, Arne Mørk, Pia Weikop

Nat Commun· March 2020

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X-ray structure based evaluation of analogs of citalopram: Compounds with increased affinity and selectivity compared with R-citalopram for the allosteric site (S2) on hSERT.
Sid Topiol, Benny Bang-Andersen, Connie Sanchez, Per Plenge, Claus J Loland

Bioorg Med Chem Lett· February 2017

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5-HT2A Receptor Binding in the Frontal Cortex of Parkinson's Disease Patients and Alpha-Synuclein Overexpressing Mice: A Postmortem Study.
Nadja Bredo Rasmussen, Mikkel Vestergaard Olesen, Tomasz Brudek, Per Plenge, Anders Bue Klein

Parkinsons Dis· August 2016

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Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the 5-HT transporter.
M Andreas B Larsen, Per Plenge, Jacob Andersen, Jonas N N Eildal, Anders S Kristensen

Br J Pharmacol· March 2016

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Serotonergic projections from the raphe nuclei to the subthalamic nucleus; a retrograde- and anterograde neuronal tracing study.
Martin Reznitsky, Per Plenge, Anders Hay-Schmidt

Neurosci Lett· January 2016

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The interaction of escitalopram and R-citalopram at the human serotonin transporter investigated in the mouse.
Jacob P R Jacobsen, Per Plenge, Benjamin D Sachs, Alan L Pehrson, Manuel Cajina

Psychopharmacology (Berl)· December 2014

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Design and synthesis of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) analogues as novel probes for the serotonin transporter S1 and S2 binding sites.
Ashwini K Banala, Peng Zhang, Per Plenge, George Cyriac, Theresa Kopajtic

J Med Chem· December 2013

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Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter.
Per Plenge, Lei Shi, Thijs Beuming, Jerez Te, Amy Hauck Newman

J Biol Chem· November 2012

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A short-term double-blind randomized controlled pilot trial with active or placebo pindolol in patients treated with venlafaxine for major depression.
Klaus Martiny, Marianne Lunde, Per Bech, Per Plenge

Nord J Psychiatry· June 2012

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Comparison of the antidepressant effects of venlafaxine and dosulepin in a naturalistic setting.
Jens Drachmann Bukh, Martin Balslev Jørgensen, Henrik Dam, Per Plenge

Nord J Psychiatry· November 2009

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A single nucleotide polymorphism in the human serotonin transporter introduces a new site for N-linked glycosylation.
Trine N Rasmussen, Per Plenge, Tina Bay, Jan Egebjerg, Ulrik Gether

Neuropharmacology· September 2009

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Chronic electroconvulsive stimulation but not chronic restraint stress modulates mRNA expression of voltage-dependent potassium channels Kv7.2 and Kv11.1 in the rat piriform cortex.
Marie-Louise Hjaeresen, Ida Hageman, Gitta Wortwein, Per Plenge, Martin Balslev Jørgensen

Brain Res· June 2008

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The serotonin transporter and 5HT2A receptor in rat brain after localized lesions.
Henrik Dam, Erling T Mellerup, Per Plenge, Rosa Winther, Gitta Wörtwein

Neurol Res· October 2007

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Allosteric effects of R- and S-citalopram on the human 5-HT transporter: evidence for distinct high- and low-affinity binding sites.
Per Plenge, Ulrik Gether, Søren G Rasmussen

Eur J Pharmacol· July 2007

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Binding characteristics of the 5-HT2A receptor antagonists altanserin and MDL 100907.
Heidi Kristiansen, Betina Elfving, Per Plenge, Lars H Pinborg, Nic Gillings

Synapse· December 2005

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High- and low-affinity binding of S-citalopram to the human serotonin transporter mutated at 20 putatively important amino acid positions.
Per Plenge, Ove Wiborg

Neurosci Lett· August 2005

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Characterization of an allosteric citalopram-binding site at the serotonin transporter.
Fenghua Chen, Mads Breum Larsen, Henrik Amtoft Neubauer, Connie Sánchez, Per Plenge

J Neurochem· January 2005

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Pindolol and the acceleration of the antidepressant response.
Per Plenge, Erling T Mellerup

J Affect Disord· August 2003

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Associative and nonassociative learning after chronic imipramine in rats.
Jesper Mogensen, Gitte Svendsen, Klara Tølbøll Lauritsen, Petra Ermens, Andreas Hasman, Per Plenge

Pharmacol Biochem Behav· August 2003

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Serotonin, locomotion, exploration, and place recall in the rat.
Jesper Mogensen, Gitta Wörtwein, Per Plenge, Erling T Mellerup

Pharmacol Biochem Behav· May 2003

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Characterization of epibatidine binding to medial habenula: potential role in analgesia.
Per Plenge, Erling T Mellerup, Gitta Wörtwein

J Pharmacol Exp Ther· August 2002

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