Publications by authors named "Peter Dempsey"

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Fully Synthetic Hydrogels Promote Robust Crypt Formation in Intestinal Organoids.
Ella A Hushka, Michael R Blatchley, Laura J Macdougall, F Max Yavitt, Bruce E Kirkpatrick, Peter J Dempsey

Adv Mater· October 2025

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Nuclei sense complex tissue shape and direct intestinal stem cell fate.
Kaustav Bera, Delaney L McNally, Bruce E Kirkpatrick, Nolan R Petrich, F Max Yavitt, Peter J Dempsey

bioRxiv· October 2025

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Tyrosine kinase inhibitors affect sweet taste and dysregulate fate selection of specific taste cell subtypes via KIT inhibition.
Christina M Piarowski, Jennifer K Scott, Courtney Wilson, Heber Lara, Ernesto Salcedo, Peter J Dempsey

bioRxiv· September 2025

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Engineered epithelial curvature controls Paneth cell localization in intestinal organoids.
F Max Yavitt, Alex Khang, Kaustav Bera, Delaney L McNally, Michael R Blatchley, Peter J Dempsey

Cell Biomater· April 2025

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H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium.
Alison R S Pashos, Anne R Meyer, Cameron Bussey-Sutton, Erin S O'Connor, Mariel Coradin, Peter J Dempsey

Nat Cell Biol· February 2025

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Synthetic photoresponsive hydrogels enable control over murine intestinal monolayer differentiation and crypt formation.
Mark W Young, Colter E Oroke, Bruce E Kirkpatrick, Michael R Blatchley, Peter J Dempsey

Adv Funct Mater· January 2025

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Fully synthetic hydrogels promote robust crypt formation in intestinal organoids.
Ella A Hushka, Michael R Blatchley, Laura J Macdougall, F Max Yavitt, Bruce E Kirkpatrick, Peter J Dempsey

bioRxiv· July 2024

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Examination of Wnt signaling as a therapeutic target for pancreatic ductal adenocarcinoma (PDAC) using a pancreatic tumor organoid library (PTOL).
Hayley J Hawkins, Betelehem W Yacob, Monica E Brown, Brandon R Goldstein, John J Arcaroli, Peter J Dempsey

PLoS One· April 2024

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High Sox2 expression predicts taste lineage competency of lingual progenitors in vitro.
Lauren A Shechtman, Jennifer K Scott, Eric D Larson, Trevor J Isner, Bryan J Johnson, Peter J Dempsey

Development· February 2023

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In situ modulation of intestinal organoid epithelial curvature through photoinduced viscoelasticity directs crypt morphogenesis.
F Max Yavitt, Bruce E Kirkpatrick, Michael R Blatchley, Kelly F Speckl, Erfan Mohagheghian, Peter J Dempsey

Sci Adv· January 2023

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Injury-Induced Cellular Plasticity Drives Intestinal Regeneration.
Anne R Meyer, Monica E Brown, Patrick S McGrath, Peter J Dempsey

Cell Mol Gastroenterol Hepatol· April 2022

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In Situ Super-Resolution Imaging of Organoids and Extracellular Matrix Interactions via Phototransfer by Allyl Sulfide Exchange-Expansion Microscopy (PhASE-ExM).
Michael R Blatchley, Kemal Arda Günay, F Max Yavitt, Elijah M Hawat, Peter J Dempsey

Adv Mater· April 2022

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Robo4 is constitutively shed by ADAMs from endothelial cells and the shed Robo4 functions to inhibit Slit3-induced angiogenesis.
Wenyuan Xiao, Alejandro Pinilla-Baquero, John Faulkner, Xuehong Song, Pradeep Prabhakar, Peter J Dempsey

Sci Rep· March 2022

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Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer.
Adam C Mueller, Miles Piper, Andrew Goodspeed, Shiv Bhuvane, Jason S Williams, Peter Dempsey

Cancer Res· June 2021

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Rapid Crypt Cell Remodeling Regenerates the Intestinal Stem Cell Niche after Notch Inhibition.
Natacha Bohin, Theresa M Keeley, Alexis J Carulli, Emily M Walker, Elizabeth A Carlson, Peter J Dempsey

Stem Cell Reports· July 2020

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The Effect of Thiol Structure on Allyl Sulfide Photodegradable Hydrogels and their Application as a Degradable Scaffold for Organoid Passaging.
F Max Yavitt, Tobin E Brown, Ella A Hushka, Monica E Brown, Nikolche Gjorevski, Peter J Dempsey

Adv Mater· July 2020

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Relaxation of Extracellular Matrix Forces Directs Crypt Formation and Architecture in Intestinal Organoids.
Ella A Hushka, F Max Yavitt, Tobin E Brown, Peter J Dempsey, Kristi S Anseth

Adv Healthc Mater· April 2020

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Adaptation to inflammatory acidity through neutrophil-derived adenosine regulation of SLC26A3.
Ian M Cartwright, Valerie F Curtis, Jordi M Lanis, Erica E Alexeev, Nichole Welch, Peter J Dempsey

Mucosal Immunol· March 2020

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Cellular Plasticity of Defa4-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury.
Jennifer C Jones, Constance D Brindley, Nicholas H Elder, Martin G Myers, Michael W Rajala, Peter J Dempsey

Cell Mol Gastroenterol Hepatol· June 2019

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ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling.
Stefanie Schmidt, Neele Schumacher, Jeanette Schwarz, Simone Tangermann, Lukas Kenner, Peter J Dempsey

J Exp Med· April 2018

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Role of ADAM10 in intestinal crypt homeostasis and tumorigenesis.
Peter J Dempsey

Biochim Biophys Acta Mol Cell Res· November 2017

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Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB.
Rielana Wichert, Anna Ermund, Stefanie Schmidt, Matthias Schweinlin, Miroslaw Ksiazek, Peter J Dempsey

Cell Rep· November 2017

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Interdependency of EGF and GLP-2 Signaling in Attenuating Mucosal Atrophy in a Mouse Model of Parenteral Nutrition.
Yongjia Feng, Farok R Demehri, Weidong Xiao, Yu-Hwai Tsai, Jennifer C Jones, Peter J Dempsey

Cell Mol Gastroenterol Hepatol· May 2017

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ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation.
Michael A Schumacher, Matija Hedl, Clara Abraham, Jessica K Bernard, Patricia R Lozano, Peter J Dempsey

Cell Death Dis· February 2017

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Enterocyte progenitors can dedifferentiate to replace lost Lgr5 intestinal stem cells revealing that many different progenitor populations can regain stemness.
Jennifer C Jones, Peter J Dempsey

Stem Cell Investig· October 2016

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