Publications by authors named "Peter Groenen"

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Reverse Engineering of Digital Measures: Inviting Patients to the Conversation.
Ieuan Clay, Nele Peerenboom, Dana E Connors, Steven Bourke, Alison Keogh, Peter M A Groenen

Digit Biomark· May 2023

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Multiple-ascending doses of ACT-1014-6470, an oral complement factor 5a receptor 1 (C5a receptor) antagonist: Tolerability, pharmacokinetics and target engagement.
Marion Anliker-Ort, Jasper Dingemanse, Hervé Farine, Peter Groenen, Rüdiger Kornberger

Br J Clin Pharmacol· January 2023

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Recommendations for robust and reproducible preclinical research in personalised medicine.
Vibeke Fosse, Emanuela Oldoni, Florence Bietrix, Alfredo Budillon, Evangelos P Daskalopoulos, Peter M A Groenen

BMC Med· January 2023

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Biomarker context-of-use: how organizational design can impact the implementation of the appropriate biomarker assay strategy.
Kyra J Cowan, Michaela Golob, Joanne Goodman, Anna Laurén, Lene Andersen, Peter Groenen

Bioanalysis· July 2022

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A molecular view of amyotrophic lateral sclerosis through the lens of interaction network modules.
Klaus Højgaard Jensen, Anna Katharina Stalder, Rasmus Wernersson, Tim-Christoph Roloff-Handschin, Daniel Hvidberg Hansen, Peter M A Groenen

PLoS One· May 2022

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Plasma neurofilament light, glial fibrillary acidic protein and lysosphingolipid biomarkers for pharmacodynamics and disease monitoring of GM2 and GM1 gangliosidoses patients.
Richard W D Welford, Herve Farine, Michel Steiner, Marco Garzotti, Kostantin Dobrenis, Peter M A Groenen

Mol Genet Metab Rep· March 2022

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Preclinical to clinical translation of cenerimod, a novel S1P receptor modulator, in systemic lupus erythematosus.
Daniel S Strasser, Sylvie Froidevaux, Virginie Sippel, Estelle Gerossier, Ursula Grieder, Peter M A Groenen

RMD Open· September 2020

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Remote digital monitoring in clinical trials in the time of COVID-19.
Jennifer C Goldsack, Elena S Izmailova, Joseph P Menetski, Steven C Hoffmann, Peter M A Groenen

Nat Rev Drug Discov· June 2020

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Impact of high-altitude therapy on type-2 immune responses in asthma patients.
Tadech Boonpiyathad, Gertruda Capova, Hans-Werner Duchna, Andrew L Croxford, Herve Farine, Peter M A Groenen

Allergy· January 2020

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Elucidating essential kinases of endothelin signalling by logic modelling of phosphoproteomics data.
Alexander Schäfer, Enio Gjerga, Richard Wd Welford, Imke Renz, Francois Lehembre, Peter Ma Groenen

Mol Syst Biol· August 2019

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Traditional and Digital Biomarkers: Two Worlds Apart?
Lmar M Babrak, Joseph Menetski, Michael Rebhan, Giovanni Nisato, Marc Zinggeler, Peter M A Groenen

Digit Biomark· August 2019

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Assessment of Peripheral Serotonin Synthesis Using Stable Isotope-Labeled Tryptophan.
Martine Gehin, Richard W D Welford, Marco Garzotti, Magali Vercauteren, Peter M A Groenen

Clin Pharmacol Ther· December 2018

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Eosinophilic oesophagitis: relevance of mast cell infiltration.
Daniel S Strasser, Shanon Seger, Christian Bussmann, Gabin M Pierlot, Peter M A Groenen

Histopathology· September 2018

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A fully automated image analysis method to quantify lung fibrosis in the bleomycin-induced rat model.
Shanon Seger, Manuel Stritt, Enrico Vezzali, Oliver Nayler, Patrick Hess, Peter M A Groenen

PLoS One· June 2018

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Biomarker-guided clinical development of the first-in-class anti-inflammatory FPR2/ALX agonist ACT-389949.
Anna K Stalder, Dominik Lott, Daniel S Strasser, Hans G Cruz, Andreas Krause, Peter M A Groenen

Br J Clin Pharmacol· March 2017

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Pharmacokinetic/Pharmacodynamic Modelling of Receptor Internalization with CRTH2 Antagonists to Optimize Dose Selection.
Andreas Krause, Jochen Zisowsky, Daniel S Strasser, Martine Gehin, Patricia N Sidharta, Peter M A Groenen

Clin Pharmacokinet· July 2016

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Serotonin biosynthesis as a predictive marker of serotonin pharmacodynamics and disease-induced dysregulation.
Richard W D Welford, Magali Vercauteren, Annette Trébaul, Christophe Cattaneo, Doriane Eckert, Peter M A Groenen

Sci Rep· July 2016

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Plasma lysosphingomyelin demonstrates great potential as a diagnostic biomarker for Niemann-Pick disease type C in a retrospective study.
Richard W D Welford, Marco Garzotti, Charles Marques Lourenço, Eugen Mengel, Thorsten Marquardt, Peter Groenen

PLoS One· April 2016

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The role of ADME pharmacogenomics in early clinical trials: perspective of the Industry Pharmacogenomics Working Group (I-PWG).
Larry Tremaine, William Brian, Terrye DelMonte, Stephan Francke, Peter Groenen

Pharmacogenomics· December 2015

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A novel CRTH2 antagonist: Single- and multiple-dose tolerability, pharmacokinetics, and pharmacodynamics of ACT-453859 in healthy subjects.
Martine Géhin, Daniel S Strasser, Jochen Zisowsky, Hervé Farine, Peter M A Groenen

J Clin Pharmacol· July 2015

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Four decades of modern pharmacogenomics: from promise to clinical utility. World PGX Summit 2011. Boston, USA, 26-27 April, 2011.
Peter Ma Groenen

Pharmacogenomics· September 2011

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Leptin and ObRa/MEK signalling in mouse oocyte maturation and preimplantation embryo development.
Yinghui Ye, Kazuhiro Kawamura, Mitsue Sasaki, Nanami Kawamura, Peter Groenen

Reprod Biomed Online· August 2009

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Kit ligand promotes first polar body extrusion of mouse preovulatory oocytes.
Yinghui Ye, Kazuhiro Kawamura, Mitsue Sasaki, Nanami Kawamura, Peter Groenen

Reprod Biol Endocrinol· April 2009

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PhyloPat: an updated version of the phylogenetic pattern database contains gene neighborhood.
Tim Hulsen, Peter M A Groenen, Jacob de Vlieg, Wynand Alkema

Nucleic Acids Res· January 2009

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Completion of Meiosis I of preovulatory oocytes and facilitation of preimplantation embryo development by glial cell line-derived neurotrophic factor.
Kazuhiro Kawamura, Yinghui Ye, Nanami Kawamura, Li Jing, Peter Groenen

Dev Biol· March 2008

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