Publications by authors named "Patrick Hess"

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Gemtuzumab ozogamicin in first-line treatment of CBF-AML: insights from a retrospective multi-center analysis.
Julian Ronnacker, Philippe J Muller, Jan-Henrik Mikesch, Sven Zukunft, Barbora Weinbergerová, Patrick P Hess

Leukemia· September 2025

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Comparison of the diagnostic concordance of tele-EMS and EMS physicians in the emergency medical service-a subanalysis of the TEMS-trial.
Patrick P Hess, Michael Czaplik, Johanna Hess, Hanna Schröder, Stefan K Beckers

Front Digit Health· April 2025

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Effective treatment of advanced Hodgkin lymphoma with a modified BEACOPP regimen for a patient with demyelinating hereditary motor and sensory neuropathy type 1 (HMSN1).
Patrick P Hess, Monica S Ventura Ferreira, Benjamin Rolles, Martin Kirschner, Florian Holtbernd

Clin Case Rep· May 2022

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Pharmacological Characterization of Aprocitentan, a Dual Endothelin Receptor Antagonist, Alone and in Combination with Blockers of the Renin Angiotensin System, in Two Models of Experimental Hypertension.
Frederic Trensz, Céline Bortolamiol, Markus Kramberg, Daniel Wanner, Hakim Hadana, Patrick Hess

J Pharmacol Exp Ther· March 2019

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A fully automated image analysis method to quantify lung fibrosis in the bleomycin-induced rat model.
Shanon Seger, Manuel Stritt, Enrico Vezzali, Oliver Nayler, Patrick Hess

PLoS One· June 2018

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Cenerimod, a novel selective S1P receptor modulator with unique signaling properties.
Luca Piali, Magdalena Birker-Robaczewska, Cyrille Lescop, Sylvie Froidevaux, Nicole Schmitz, Patrick Hess

Pharmacol Res Perspect· December 2017

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The reversible P2Y antagonist ACT-246475 causes significantly less blood loss than ticagrelor at equivalent antithrombotic efficacy in rat.
Markus Rey, Markus Kramberg, Patrick Hess, Keith Morrison, Roland Ernst

Pharmacol Res Perspect· October 2017

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Selexipag Active Metabolite ACT-333679 Displays Strong Anticontractile and Antiremodeling Effects but Low -Arrestin Recruitment and Desensitization Potential.
John Gatfield, Katalin Menyhart, Daniel Wanner, Carmela Gnerre, Lucile Monnier, Patrick Hess

J Pharmacol Exp Ther· July 2017

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Endothelin ET Receptor Blockade, by Activating ET Receptors, Increases Vascular Permeability and Induces Exaggerated Fluid Retention.
Magali Vercauteren, Frederic Trensz, Anne Pasquali, Christophe Cattaneo, Daniel S Strasser, Patrick Hess

J Pharmacol Exp Ther· May 2017

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Synthesis and Characterization of Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Antibacterial Activity against Gram-Negative Bacteria.
Jean-Philippe Surivet, Cornelia Zumbrunn, Thierry Bruyère, Daniel Bur, Christopher Kohl, Patrick Hess

J Med Chem· May 2017

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Novel S1P1 receptor agonists - Part 5: From amino-to alkoxy-pyridines.
Martin H Bolli, Cyrille Lescop, Magdalena Birker, Ruben de Kanter, Patrick Hess

Eur J Med Chem· June 2016

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Novel S1P1 receptor agonists - Part 4: Alkylaminomethyl substituted aryl head groups.
Cyrille Lescop, Claus Müller, Boris Mathys, Magdalena Birker, Ruben de Kanter, Patrick Hess

Eur J Med Chem· June 2016

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4-((R)-2-{[6-((S)-3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic Acid Butyl Ester (ACT-246475) and Its Prodrug (ACT-281959), a Novel P2Y12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel.
Eva Caroff, Francis Hubler, Emmanuel Meyer, Dorte Renneberg, Carmela Gnerre, Patrick Hess

J Med Chem· December 2015

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Comparison of Macitentan and Bosentan on Right Ventricular Remodeling in a Rat Model of Non-vasoreactive Pulmonary Hypertension.
Marc Iglarz, Kyle Landskroner, Yasmina Bauer, Magali Vercauteren, Markus Rey, Patrick Hess

J Cardiovasc Pharmacol· November 2015

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Vascular Effects of Endothelin Receptor Antagonists Depends on Their Selectivity for ETA Versus ETB Receptors and on the Functionality of Endothelial ETB Receptors.
Marc Iglarz, Pauline Steiner, Daniel Wanner, Markus Rey, Patrick Hess

J Cardiovasc Pharmacol· October 2015

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Discovery of novel bridged tetrahydronaphthalene derivatives as potent T/L-type calcium channel blockers.
Dorte Renneberg, Francis Hubler, Markus Rey, Patrick Hess, Stephane Delahaye

Bioorg Med Chem Lett· September 2015

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A novel genomic signature with translational significance for human idiopathic pulmonary fibrosis.
Yasmina Bauer, John Tedrow, Simon de Bernard, Magdalena Birker-Robaczewska, Kevin F Gibson, Patrick Hess

Am J Respir Cell Mol Biol· February 2015

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Novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram positive activity and improved safety profile.
Jean-Philippe Surivet, Cornelia Zumbrunn, Georg Rueedi, Daniel Bur, Thierry Bruyère, Patrick Hess

J Med Chem· January 2015

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Comparison of pharmacological activity of macitentan and bosentan in preclinical models of systemic and pulmonary hypertension.
Marc Iglarz, Alexandre Bossu, Daniel Wanner, Céline Bortolamiol, Markus Rey, Patrick Hess

Life Sci· November 2014

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Macitentan does not interfere with hepatic bile salt transport.
Alexander Treiber, Päivi Äänismaa, Ruben de Kanter, Stephane Delahaye, Marianne Treher, Patrick Hess

J Pharmacol Exp Ther· July 2014

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Desensitization by progressive up-titration prevents first-dose effects on the heart: guinea pig study with ponesimod, a selective S1P1 receptor modulator.
Markus Rey, Patrick Hess, Martine Clozel, Stéphane Delahaye, John Gatfield

PLoS One· May 2014

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Novel S1P(1) receptor agonists--part 2: from bicyclo[3.1.0]hexane-fused thiophenes to isobutyl substituted thiophenes.
Martin H Bolli, Jörg Velker, Claus Müller, Boris Mathys, Magdalena Birker, Patrick Hess

J Med Chem· January 2014

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Novel S1P(1) receptor agonists--part 3: from thiophenes to pyridines.
Martin H Bolli, Stefan Abele, Magdalena Birker, Roberto Bravo, Daniel Bur, Patrick Hess

J Med Chem· January 2014

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Novel S1P1 receptor agonists--part 1: From pyrazoles to thiophenes.
Martin H Bolli, Claus Müller, Boris Mathys, Stefan Abele, Magdalena Birker, Patrick Hess

J Med Chem· December 2013

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The discovery of N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide (Macitentan), an orally active, potent dual endothelin receptor antagonist.
Martin H Bolli, Christoph Boss, Christoph Binkert, Stephan Buchmann, Daniel Bur, Patrick Hess

J Med Chem· September 2012

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