Publications by authors named "Markus Rey"

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Discovery of IDOR-1117-1680, a dual orexin receptor antagonist with fast onset and short duration of action for the treatment of insomnia.
Jean-Philippe Surivet, Elise M Jacob, Melanie Kessler, Christopher Kohl, Catherine Vaillant, Markus Rey

Bioorg Med Chem· May 2025

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The novel lysophosphatidic acid receptor 1-selective antagonist, ACT-1016-0707, has unique binding properties that translate into effective antifibrotic and anti-inflammatory activity in different models of pulmonary fibrosis.
Magdalena Birker-Robaczewska, Maxime Boucher, Giulia Ranieri, Sylvie Poirey, Rolf Studer, Markus Rey

J Pharmacol Exp Ther· March 2025

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Discovery of Clinical Candidate ACT-777991, a Potent CXCR3 Antagonist for Antigen-Driven and Inflammatory Pathologies.
Emmanuel A Meyer, Päivi Äänismaa, Eric A Ertel, Eva Hühn, Daniel S Strasser, Markus Rey

J Med Chem· March 2023

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The P2Y12 Receptor Antagonist Selatogrel Dissolves Preformed Platelet Thrombi In Vivo.
Lydie Crescence, Markus Kramberg, Martine Baumann, Markus Rey, Sebastien Roux

J Clin Med· November 2021

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Pharmacological Characterization of Aprocitentan, a Dual Endothelin Receptor Antagonist, Alone and in Combination with Blockers of the Renin Angiotensin System, in Two Models of Experimental Hypertension.
Frederic Trensz, Céline Bortolamiol, Markus Kramberg, Daniel Wanner, Hakim Hadana, Markus Rey

J Pharmacol Exp Ther· March 2019

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S1P Modulator-Induced G Signaling and -Arrestin Recruitment Are Both Necessary to Induce Rapid and Efficient Reduction of Blood Lymphocyte Count In Vivo.
Magdalena Birker-Robaczewska, Martin Bolli, Markus Rey, Ruben de Kanter, Christopher Kohl, Sylvie Poirey

Mol Pharmacol· February 2018

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Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies.
Olivier Bezençon, Bibia Heidmann, Romain Siegrist, Simon Stamm, Sylvia Richard, Isabelle Reymond, Markus Rey

J Med Chem· December 2017

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Cenerimod, a novel selective S1P receptor modulator with unique signaling properties.
Luca Piali, Magdalena Birker-Robaczewska, Cyrille Lescop, Sylvie Froidevaux, Nicole Schmitz, Markus Rey

Pharmacol Res Perspect· December 2017

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The reversible P2Y antagonist ACT-246475 causes significantly less blood loss than ticagrelor at equivalent antithrombotic efficacy in rat.
Markus Rey, Markus Kramberg, Patrick Hess, Keith Morrison, Roland Ernst

Pharmacol Res Perspect· October 2017

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Milestones to the Discovery of T-type Calcium Channel Blockers for the Treatment of Generalized Epilepsies.
Olivier Bezençon, Romain Siegrist, Bibia Heidmann, Davide Pozzi, Simon Stamm, Isabelle Reymond, Markus Rey

Chimia (Aarau)· October 2017

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Preparation, Antiepileptic Activity, and Cardiovascular Safety of Dihydropyrazoles as Brain-Penetrant T-Type Calcium Channel Blockers.
Lubos Remen, Olivier Bezençon, Lloyd Simons, Rick Gaston, Dennis Downing, Markus Rey

J Med Chem· September 2016

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Novel S1P1 receptor agonists - Part 5: From amino-to alkoxy-pyridines.
Martin H Bolli, Cyrille Lescop, Magdalena Birker, Ruben de Kanter, Patrick Hess, Markus Rey

Eur J Med Chem· June 2016

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Novel S1P1 receptor agonists - Part 4: Alkylaminomethyl substituted aryl head groups.
Cyrille Lescop, Claus Müller, Boris Mathys, Magdalena Birker, Ruben de Kanter, Markus Rey

Eur J Med Chem· June 2016

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4-((R)-2-{[6-((S)-3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic Acid Butyl Ester (ACT-246475) and Its Prodrug (ACT-281959), a Novel P2Y12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel.
Eva Caroff, Francis Hubler, Emmanuel Meyer, Dorte Renneberg, Carmela Gnerre, Markus Rey

J Med Chem· December 2015

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Comparison of Macitentan and Bosentan on Right Ventricular Remodeling in a Rat Model of Non-vasoreactive Pulmonary Hypertension.
Marc Iglarz, Kyle Landskroner, Yasmina Bauer, Magali Vercauteren, Markus Rey

J Cardiovasc Pharmacol· November 2015

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Vascular Effects of Endothelin Receptor Antagonists Depends on Their Selectivity for ETA Versus ETB Receptors and on the Functionality of Endothelial ETB Receptors.
Marc Iglarz, Pauline Steiner, Daniel Wanner, Markus Rey, Patrick Hess

J Cardiovasc Pharmacol· October 2015

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Discovery of novel bridged tetrahydronaphthalene derivatives as potent T/L-type calcium channel blockers.
Dorte Renneberg, Francis Hubler, Markus Rey, Patrick Hess, Stephane Delahaye

Bioorg Med Chem Lett· September 2015

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A novel genomic signature with translational significance for human idiopathic pulmonary fibrosis.
Yasmina Bauer, John Tedrow, Simon de Bernard, Magdalena Birker-Robaczewska, Kevin F Gibson, Sylvie Poirey, Markus Rey

Am J Respir Cell Mol Biol· February 2015

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Comparison of pharmacological activity of macitentan and bosentan in preclinical models of systemic and pulmonary hypertension.
Marc Iglarz, Alexandre Bossu, Daniel Wanner, Céline Bortolamiol, Markus Rey

Life Sci· November 2014

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Desensitization by progressive up-titration prevents first-dose effects on the heart: guinea pig study with ponesimod, a selective S1P1 receptor modulator.
Markus Rey, Patrick Hess, Martine Clozel, Stéphane Delahaye, John Gatfield

PLoS One· May 2014

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Novel S1P(1) receptor agonists--part 2: from bicyclo[3.1.0]hexane-fused thiophenes to isobutyl substituted thiophenes.
Martin H Bolli, Jörg Velker, Claus Müller, Boris Mathys, Magdalena Birker, Markus Rey

J Med Chem· January 2014

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Novel S1P(1) receptor agonists--part 3: from thiophenes to pyridines.
Martin H Bolli, Stefan Abele, Magdalena Birker, Roberto Bravo, Daniel Bur, Markus Rey

J Med Chem· January 2014

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Novel S1P1 receptor agonists--part 1: From pyrazoles to thiophenes.
Martin H Bolli, Claus Müller, Boris Mathys, Stefan Abele, Magdalena Birker, Markus Rey

J Med Chem· December 2013

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The discovery of N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide (Macitentan), an orally active, potent dual endothelin receptor antagonist.
Martin H Bolli, Christoph Boss, Christoph Binkert, Stephan Buchmann, Daniel Bur, Markus Rey

J Med Chem· September 2012

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Simultaneous pulmonary and systemic blood pressure and ECG Interval measurement in conscious, freely moving rats.
Markus Rey, Edgar W Weber, Patrick D Hess

J Am Assoc Lab Anim Sci· March 2012

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