Publications by authors named "Bibia Heidmann"

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The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia Disorders.
Christoph Boss, John Gatfield, Christine Brotschi, Bibia Heidmann, Thierry Sifferlen

ChemMedChem· December 2020

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From Oxadiazole to Triazole Analogues: Optimization toward a Dual Orexin Receptor Antagonist with Improved in vivo Efficacy in Dogs.
Christine Brotschi, Martin H Bolli, John Gatfield, Bibia Heidmann, Francois Jenck

ChemMedChem· March 2020

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Oxadiazole Derivatives as Dual Orexin Receptor Antagonists: Synthesis, Structure-Activity Relationships, and Sleep-Promoting Properties in Rats.
Christine Brotschi, Catherine Roch, John Gatfield, Alexander Treiber, Jodi T Williams, Bibia Heidmann

ChemMedChem· July 2019

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Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies.
Olivier Bezençon, Bibia Heidmann, Romain Siegrist, Simon Stamm, Sylvia Richard

J Med Chem· December 2017

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Milestones to the Discovery of T-type Calcium Channel Blockers for the Treatment of Generalized Epilepsies.
Olivier Bezençon, Romain Siegrist, Bibia Heidmann, Davide Pozzi, Simon Stamm

Chimia (Aarau)· October 2017

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Discovery of Highly Potent Dual Orexin Receptor Antagonists via a Scaffold-Hopping Approach.
Bibia Heidmann, John Gatfield, Catherine Roch, Alexander Treiber, Simone Tortoioli

ChemMedChem· October 2016

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Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling.
Amélie Le Bihan, Ruben de Kanter, Iñigo Angulo-Barturen, Christoph Binkert, Christoph Boss, Bibia Heidmann

PLoS Med· October 2016

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Discovery and Characterization of ACT-451840: an Antimalarial Drug with a Novel Mechanism of Action.
Christoph Boss, Hamed Aissaoui, Nathalie Amaral, Aude Bauer, Stephanie Bazire, Bibia Heidmann

ChemMedChem· September 2016

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Substituted pyrrolidin-2-ones: Centrally acting orexin receptor antagonists promoting sleep. Part 2.
Thierry Sifferlen, Amandine Boller, Audrey Chardonneau, Emmanuelle Cottreel, John Gatfield, Bibia Heidmann

Bioorg Med Chem Lett· May 2015

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Structure-activity relationship, biological, and pharmacological characterization of the proline sulfonamide ACT-462206: a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist.
Christoph Boss, Catherine Roch-Brisbare, Michel A Steiner, Alexander Treiber, Hendrik Dietrich, Bibia Heidmann

ChemMedChem· November 2014

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Discovery of substituted lactams as novel dual orexin receptor antagonists. Synthesis, preliminary structure-activity relationship studies and efforts towards improved metabolic stability and pharmacokinetic properties. Part 1.
Thierry Sifferlen, Amandine Boller, Audrey Chardonneau, Emmanuelle Cottreel, Johannes Hoecker, Bibia Heidmann

Bioorg Med Chem Lett· February 2014

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UV-triggered affinity capture identifies interactions between the Plasmodium falciparum multidrug resistance protein 1 (PfMDR1) and antimalarial agents in live parasitized cells.
Ralf Brunner, Caroline L Ng, Hamed Aissaoui, Myles H Akabas, Christoph Boss, Bibia Heidmann

J Biol Chem· August 2013

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Identification of a new chemical class of antimalarials.
Ralf Brunner, Hamed Aissaoui, Christoph Boss, Zbynek Bozdech, Reto Brun, Bibia Heidmann

J Infect Dis· September 2012

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