Publications by authors named "Francois Jenck"

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Anxiolytic-like effects of the dual orexin receptor antagonist daridorexant in rats.
Michel Alexander Steiner, Rebekka Locher, Hugues Lecourt, Francois Jenck

Neurosci Appl· March 2024

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From Oxadiazole to Triazole Analogues: Optimization toward a Dual Orexin Receptor Antagonist with Improved in vivo Efficacy in Dogs.
Christine Brotschi, Martin H Bolli, John Gatfield, Bibia Heidmann, Francois Jenck

ChemMedChem· March 2020

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Oxadiazole Derivatives as Dual Orexin Receptor Antagonists: Synthesis, Structure-Activity Relationships, and Sleep-Promoting Properties in Rats.
Christine Brotschi, Catherine Roch, John Gatfield, Alexander Treiber, Jodi T Williams, Francois Jenck

ChemMedChem· July 2019

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The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468.
Alexander Treiber, Ruben de Kanter, Catherine Roch, John Gatfield, Christoph Boss, Francois Jenck

J Pharmacol Exp Ther· September 2017

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Discovery of Highly Potent Dual Orexin Receptor Antagonists via a Scaffold-Hopping Approach.
Bibia Heidmann, John Gatfield, Catherine Roch, Alexander Treiber, Simone Tortoioli, François Jenck

ChemMedChem· October 2016

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Substituted pyrrolidin-2-ones: Centrally acting orexin receptor antagonists promoting sleep. Part 2.
Thierry Sifferlen, Amandine Boller, Audrey Chardonneau, Emmanuelle Cottreel, John Gatfield, Francois Jenck

Bioorg Med Chem Lett· May 2015

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Orexin neuropeptides contribute to the development and persistence of generalized avoidance behavior in the rat.
Daniele Viviani, Patrizia Haegler, Francois Jenck, Michel A Steiner

Psychopharmacology (Berl)· April 2015

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Structure-activity relationship, biological, and pharmacological characterization of the proline sulfonamide ACT-462206: a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist.
Christoph Boss, Catherine Roch-Brisbare, Michel A Steiner, Alexander Treiber, Hendrik Dietrich, Francois Jenck

ChemMedChem· November 2014

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Discovery of substituted lactams as novel dual orexin receptor antagonists. Synthesis, preliminary structure-activity relationship studies and efforts towards improved metabolic stability and pharmacokinetic properties. Part 1.
Thierry Sifferlen, Amandine Boller, Audrey Chardonneau, Emmanuelle Cottreel, Johannes Hoecker, Francois Jenck

Bioorg Med Chem Lett· February 2014

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The selective orexin receptor 1 antagonist ACT-335827 in a rat model of diet-induced obesity associated with metabolic syndrome.
Michel A Steiner, Carla Sciarretta, Anne Pasquali, Francois Jenck

Front Pharmacol· January 2014

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Structure-activity relationship studies and sleep-promoting activity of novel 1-chloro-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Part 2.
Thierry Sifferlen, Ralf Koberstein, Emmanuelle Cottreel, Amandine Boller, Thomas Weller, Francois Jenck

Bioorg Med Chem Lett· July 2013

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Discovery and characterization of ACT-335827, an orally available, brain penetrant orexin receptor type 1 selective antagonist.
Michel A Steiner, John Gatfield, Catherine Brisbare-Roch, Hendrik Dietrich, Alexander Treiber, Francois Jenck

ChemMedChem· June 2013

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Examining the role of endogenous orexins in hypothalamus-pituitary-adrenal axis endocrine function using transient dual orexin receptor antagonism in the rat.
Michel A Steiner, Carla Sciarretta, Catherine Brisbare-Roch, Daniel S Strasser, Rolf Studer, Francois Jenck

Psychoneuroendocrinology· April 2013

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Synthesis, structure-activity relationship studies, and identification of novel 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Part 1.
Thierry Sifferlen, Ralf Koberstein, Emmanuelle Cottreel, Amandine Boller, Thomas Weller, Francois Jenck

Bioorg Med Chem Lett· April 2013

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The dual orexin receptor antagonist almorexant, alone and in combination with morphine, cocaine and amphetamine, on conditioned place preference and locomotor sensitization in the rat.
Michel Alexander Steiner, Hugues Lecourt, François Jenck

Int J Neuropsychopharmacol· March 2013

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The brain orexin system and almorexant in fear-conditioned startle reactions in the rat.
Michel A Steiner, Hugues Lecourt, Francois Jenck

Psychopharmacology (Berl)· October 2012

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Favoured genetic background for testing anxiolytics in the fear-potentiated and light-enhanced startle paradigms in the rat.
Michel A Steiner, Hugues Lecourt, Ando Rakotoariniaina, Francois Jenck

Behav Brain Res· August 2011

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Differential effects of the dual orexin receptor antagonist almorexant and the GABA(A)-α1 receptor modulator zolpidem, alone or combined with ethanol, on motor performance in the rat.
Michel A Steiner, Hugues Lecourt, Daniel S Strasser, Catherine Brisbare-Roch, François Jenck

Neuropsychopharmacology· March 2011

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Intact learning and memory in rats following treatment with the dual orexin receptor antagonist almorexant.
Hendrik Dietrich, François Jenck

Psychopharmacology (Berl)· October 2010

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Orexin receptor antagonists: a new concept in CNS disorders?
John Gatfield, Catherine Brisbare-Roch, Francois Jenck, Christoph Boss

ChemMedChem· August 2010

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Novel pyrazolo-tetrahydropyridines as potent orexin receptor antagonists.
Thierry Sifferlen, Christoph Boss, Emmanuelle Cottreel, Ralf Koberstein, Markus Gude, Francois Jenck

Bioorg Med Chem Lett· March 2010

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Biomedical application of orexin/hypocretin receptor ligands in neuroscience.
Christoph Boss, Catherine Brisbare-Roch, Francois Jenck

J Med Chem· February 2009

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N-Glycine-sulfonamides as potent dual orexin 1/orexin 2 receptor antagonists.
Hamed Aissaoui, Ralf Koberstein, Cornelia Zumbrunn, John Gatfield, Catherine Brisbare-Roch, Francois Jenck

Bioorg Med Chem Lett· November 2008

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Promotion of sleep by targeting the orexin system in rats, dogs and humans.
Catherine Brisbare-Roch, Jasper Dingemanse, Ralf Koberstein, Petra Hoever, Hamed Aissaoui, François Jenck

Nat Med· February 2007

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Novel hexahydrospiro[piperidine-4,1'-pyrrolo[3,4-c]pyrroles]: highly selective small-molecule nociceptin/orphanin FQ receptor agonists.
Sabine Kolczewski, Geo Adam, Andrea M Cesura, François Jenck, Michael Hennig

J Med Chem· January 2003

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