Publications by authors named "Geo Adam"

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Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists.
Thomas J Woltering, Jürgen Wichmann, Erwin Goetschi, Geo Adam, James N C Kew

Bioorg Med Chem Lett· April 2008

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Asymmetric synthesis and receptor pharmacology of the group II mGlu receptor ligand (1S,2R,3R,5R,6S)-2-amino-3-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid-HYDIA.
Thomas J Woltering, Geo Adam, Philipp Huguenin, Jürgen Wichmann, Sabine Kolczewski

ChemMedChem· February 2008

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Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: part 2. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists.
Thomas J Woltering, Geo Adam, Jürgen Wichmann, Erwin Goetschi, James N C Kew

Bioorg Med Chem Lett· February 2008

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Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: new potent non-competitive metabotropic glutamate receptor 2/3 antagonists. Part 1.
Thomas J Woltering, Geo Adam, Alexander Alanine, Jürgen Wichmann, Frédéric Knoflach

Bioorg Med Chem Lett· December 2007

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Ro 64-6198 [(1S,3aS)-8-(2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one] acts differently from nociceptin/orphanin FQ in rat periaqueductal gray slices.
Lih-Chu Chiou, Kuang-Chieh Chuang, Juergen Wichmann, Geo Adam

J Pharmacol Exp Ther· November 2004

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Pharmacological manipulation of mGlu2 receptors influences cognitive performance in the rodent.
Guy A Higgins, Theresa M Ballard, James N C Kew, J Grayson Richards, John A Kemp, Geo Adam

Neuropharmacology· June 2004

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Mutational analysis and molecular modeling of the allosteric binding site of a novel, selective, noncompetitive antagonist of the metabotropic glutamate 1 receptor.
Pari Malherbe, Nicole Kratochwil, Frédéric Knoflach, Marie-Thérèse Zenner, James N C Kew, Geo Adam

J Biol Chem· March 2003

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Novel hexahydrospiro[piperidine-4,1'-pyrrolo[3,4-c]pyrroles]: highly selective small-molecule nociceptin/orphanin FQ receptor agonists.
Sabine Kolczewski, Geo Adam, Andrea M Cesura, François Jenck, Michael Hennig

J Med Chem· January 2003

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Parallel solution- and solid-phase synthesis of spiropyrrolo-pyrroles as novel neurokinin receptor ligands.
Konrad H Bleicher, Yves Wüthrich, Geo Adam, Torsten Hoffmann, Andrew J Sleight

Bioorg Med Chem Lett· November 2002

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Role of caspase-3 activation in cerebral ischemia-induced neurodegeneration in adult and neonatal brain.
Ramanjit Gill, Marc Soriano, Klas Blomgren, Henrik Hagberg, Remy Wybrecht, Geo Adam

J Cereb Blood Flow Metab· April 2002

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