Publications by authors named "Alexander Alanine"

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Author Correction: A novel antibiotic class targeting the lipopolysaccharide transporter.
Claudia Zampaloni, Patrizio Mattei, Konrad Bleicher, Lotte Winther, Claudia Thäte, Alexander Alanine

Nature· July 2024

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A novel antibiotic class targeting the lipopolysaccharide transporter.
Claudia Zampaloni, Patrizio Mattei, Konrad Bleicher, Lotte Winther, Claudia Thäte, Alexander Alanine

Nature· January 2024

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Diversity oriented biosynthesis via accelerated evolution of modular gene clusters.
Aleksandra Wlodek, Steve G Kendrew, Nigel J Coates, Adam Hold, Joanna Pogwizd, Alexander Alanine

Nat Commun· October 2017

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Seamless integration of dose-response screening and flow chemistry: efficient generation of structure-activity relationship data of β-secretase (BACE1) inhibitors.
Michael Werner, Christoph Kuratli, Rainer E Martin, Remo Hochstrasser, David Wechsler, Alexander I Alanine

Angew Chem Int Ed Engl· February 2014

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Towards the enantioselective synthesis of (-)-euonyminol--preparation of a fully functionalised lower-rim model.
Matthew J Webber, Sarah A Warren, Damian M Grainger, Matthew Weston, Stacy Clark, Alexander Alanine

Org Biomol Chem· April 2013

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Neighborhood-preserving visualization of adaptive structure-activity landscapes: application to drug discovery.
Michael Reutlinger, Wolfgang Guba, Rainer E Martin, Alexander I Alanine, Torsten Hoffmann

Angew Chem Int Ed Engl· December 2011

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Selective GlyT1 inhibitors: discovery of [4-(3-fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a promising novel medicine to treat schizophrenia.
Emmanuel Pinard, Alexander Alanine, Daniela Alberati, Markus Bender, Edilio Borroni

J Med Chem· June 2010

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Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation.
Jens-Uwe Peters, Thomas Lübbers, Alexander Alanine, Sabine Kolczewski, Francesca Blasco

Bioorg Med Chem Lett· January 2008

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Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: optimising brain penetration.
Jens-Uwe Peters, Thomas Lübbers, Alexander Alanine, Sabine Kolczewski, Francesca Blasco

Bioorg Med Chem Lett· January 2008

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Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: new potent non-competitive metabotropic glutamate receptor 2/3 antagonists. Part 1.
Thomas J Woltering, Geo Adam, Alexander Alanine, Jürgen Wichmann, Frédéric Knoflach

Bioorg Med Chem Lett· December 2007

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Synthesis and SAR evaluation of 1,2,4-triazoles as A(2A) receptor antagonists.
Alexander Alanine, Lilli Anselm, Lucinda Steward, Stefan Thomi, Walter Vifian

Bioorg Med Chem Lett· February 2004

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1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists.
Alexander Alanine, Anne Bourson, Bernd Büttelmann, Ramanjit Gill, Marie Paule Heitz

Bioorg Med Chem Lett· October 2003

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4-(3,4-dihydro-1H-isoquinolin-2yl)-pyridines and 4-(3,4-dihydro-1H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor antagonists.
Bernd Büttelmann, Alexander Alanine, Anne Bourson, Ramanjit Gill, Marie-Paule Heitz

Bioorg Med Chem Lett· May 2003

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Hit and lead generation: beyond high-throughput screening.
Konrad H Bleicher, Hans-Joachim Böhm, Klaus Müller, Alexander I Alanine

Nat Rev Drug Discov· May 2003

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2-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists.
Bernd Büttelmann, Alexander Alanine, Anne Bourson, Ramanjit Gill, Marie-Paule Heitz

Bioorg Med Chem Lett· March 2003

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Lead generation--enhancing the success of drug discovery by investing in the hit to lead process.
Alexander Alanine, Matthias Nettekoven, Edward Roberts, Andrew W Thomas

Comb Chem High Throughput Screen· February 2003

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4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists.
Emmanuel Pinard, Alexander Alanine, Anne Bourson, Bernd Büttelmann, Marie Heitz

Bioorg Med Chem Lett· September 2002

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A virtual screening method for prediction of the HERG potassium channel liability of compound libraries.
Olivier Roche, Gerhard Trube, Jochen Zuegge, Pascal Pflimlin, Alexander Alanine

Chembiochem· May 2002

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Development of a virtual screening method for identification of "frequent hitters" in compound libraries.
Olivier Roche, Petra Schneider, Jochen Zuegge, Wolfgang Guba, Manfred Kansy, Alexander Alanine

J Med Chem· January 2002

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