Publications by authors named "Gerhard Trube"

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Basmisanil, a highly selective GABA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man.
Joerg F Hipp, Frederic Knoflach, Robert Comley, Theresa M Ballard, Michael Honer, Gerhard Trube

Sci Rep· April 2021

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Alterations in High-Frequency Neuronal Oscillations in a Cynomolgus Macaque Test of Sustained Attention Following NMDA Receptor Antagonism.
Anushka V Goonawardena, Jaime Heiss, Courtney Glavis-Bloom, Gerhard Trube, Edilio Borroni

Neuropsychopharmacology· April 2016

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TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity.
Florent G Revel, Jean-Luc Moreau, Raul R Gainetdinov, Amyaouch Bradaia, Tatyana D Sotnikova, Gerhard Trube

Proc Natl Acad Sci U S A· May 2011

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The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system.
Amyaouch Bradaia, Gerhard Trube, Henri Stalder, Roger D Norcross, Laurence Ozmen

Proc Natl Acad Sci U S A· November 2009

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Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA(A) alpha5 inverse agonist series.
Guido Achermann, Theresa M Ballard, Francesca Blasco, Pierre-Emmanuel Broutin, Bernd Büttelmann, Gerhard Trube

Bioorg Med Chem Lett· October 2009

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Imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepines as potent and highly selective GABAA alpha5 inverse agonists with potential for the treatment of cognitive dysfunction.
Bernd Buettelmann, Theresa M Ballard, Rodolfo Gasser, Holger Fischer, Maria-Clemencia Hernandez, Gerhard Trube

Bioorg Med Chem Lett· October 2009

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The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment of cognitive dysfunction.
Henner Knust, Guido Achermann, Theresa Ballard, Bernd Buettelmann, Rodolfo Gasser, Gerhard Trube

Bioorg Med Chem Lett· October 2009

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RO4938581, a novel cognitive enhancer acting at GABAA alpha5 subunit-containing receptors.
Theresa M Ballard, Frédéric Knoflach, Eric Prinssen, Edilio Borroni, Jeffrey A Vivian, Gerhard Trube

Psychopharmacology (Berl)· January 2009

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Evaluation of a high-throughput fluorescence assay method for HERG potassium channel inhibition.
Arnulf Dorn, Francis Hermann, Andreas Ebneth, Hendrick Bothmann, Gerhard Trube

J Biomol Screen· June 2005

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1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists.
Alexander Alanine, Anne Bourson, Bernd Büttelmann, Ramanjit Gill, Marie Paule Heitz, Gerhard Trube

Bioorg Med Chem Lett· October 2003

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4-(3,4-dihydro-1H-isoquinolin-2yl)-pyridines and 4-(3,4-dihydro-1H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor antagonists.
Bernd Büttelmann, Alexander Alanine, Anne Bourson, Ramanjit Gill, Marie-Paule Heitz, Gerhard Trube

Bioorg Med Chem Lett· May 2003

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2-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists.
Bernd Büttelmann, Alexander Alanine, Anne Bourson, Ramanjit Gill, Marie-Paule Heitz, Gerhard Trube

Bioorg Med Chem Lett· March 2003

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Activation of GABA(A) receptors by guanidinoacetate: a novel pathophysiological mechanism.
Axel Neu, Henrike Neuhoff, Gerhard Trube, Susanne Fehr, Kurt Ullrich

Neurobiol Dis· November 2002

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4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists.
Emmanuel Pinard, Alexander Alanine, Anne Bourson, Bernd Büttelmann, Marie Heitz, Gerhard Trube

Bioorg Med Chem Lett· September 2002

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A virtual screening method for prediction of the HERG potassium channel liability of compound libraries.
Olivier Roche, Gerhard Trube, Jochen Zuegge, Pascal Pflimlin, Alexander Alanine

Chembiochem· May 2002

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