Publications by authors named "Eric Prinssen"

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Preclinical pharmacology of alogabat: a novel GABA-α5 positive allosteric modulator targeting neurodevelopmental disorders with impaired GABA signaling.
Giuseppe Cecere, Theresa M Ballard, Frederic Knoflach, Michael Honer, Joerg F Hipp, Eric P Prinssen

Front Pharmacol· July 2025

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Behavioral analysis through the lifespan of mutant zebrafish identifies defects in sensorimotor transformation.
Brock R Pluimer, Devin L Harrison, Chanon Boonyavairoje, Eric P Prinssen, Mark Rogers-Evans

iScience· July 2023

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Basmisanil, a highly selective GABA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man.
Joerg F Hipp, Frederic Knoflach, Robert Comley, Theresa M Ballard, Michael Honer, Eric Prinssen

Sci Rep· April 2021

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Evolution of a maternal immune activation (mIA) model in rats: Early developmental effects.
Katie N Murray, Michelle E Edye, Maurizio Manca, Anthony C Vernon, Joanna M Oladipo, Eric P Prinssen

Brain Behav Immun· January 2019

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Mapping the impact of exposure to maternal immune activation on juvenile Wistar rat brain macro- and microstructure during early post-natal development.
Tobias C Wood, Michelle E Edye, Michael K Harte, Joanna C Neill, Eric P Prinssen

Brain Neurosci Adv· January 2019

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The great barrier belief: The blood-brain barrier and considerations for juvenile toxicity studies.
Georg Schmitt, Neil Parrott, Eric Prinssen, Paul Barrow

Reprod Toxicol· September 2017

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Sembragiline: A Novel, Selective Monoamine Oxidase Type B Inhibitor for the Treatment of Alzheimer's Disease.
Edilio Borroni, Bernd Bohrmann, Fiona Grueninger, Eric Prinssen, Stephane Nave

J Pharmacol Exp Ther· September 2017

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Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds.
Giancarlo Bruni, Andrew J Rennekamp, Andrea Velenich, Matthew McCarroll, Leo Gendelev, Eric Prinssen

Nat Chem Biol· July 2016

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Failed trials for central nervous system disorders do not necessarily invalidate preclinical models and drug targets.
Anton Bespalov, Thomas Steckler, Bruce Altevogt, Elena Koustova, Phil Skolnick, Eric Prinssen

Nat Rev Drug Discov· July 2016

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Characterization of the Discriminative Stimulus Effects of a NOP Receptor Agonist Ro 64-6198 in Rhesus Monkeys.
Phillip A Saccone, Kathy A Zelenock, Angela M Lindsey, Agnieszka Sulima, Kenner C Rice, Eric P Prinssen

J Pharmacol Exp Ther· April 2016

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"Domain gauges": A reference system for multivariate profiling of brain fMRI activation patterns induced by psychoactive drugs in rats.
Andreas Bruns, Thomas Mueggler, Basil Künnecke, Céline Risterucci, Eric P Prinssen

Neuroimage· May 2015

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Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression.
Lothar Lindemann, Richard H Porter, Sebastian H Scharf, Basil Kuennecke, Andreas Bruns, Eric Prinssen

J Pharmacol Exp Ther· April 2015

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Can 5-HT3 antagonists contribute toward the treatment of schizophrenia?
Bart A Ellenbroek, Eric P M Prinssen

Behav Pharmacol· February 2015

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Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases.
Georg Jaeschke, Sabine Kolczewski, Will Spooren, Eric Vieira, Nadia Bitter-Stoll, Eric Prinssen

J Med Chem· February 2015

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Maternal immune activation and abnormal brain development across CNS disorders.
Irene Knuesel, Laurie Chicha, Markus Britschgi, Scott A Schobel, Michael Bodmer, Eric P Prinssen

Nat Rev Neurol· November 2014

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The nociceptin orphanin FQ peptide receptor agonist, Ro64-6198, impairs recognition memory formation through interaction with glutamatergic but not cholinergic receptor antagonists.
David Reiss, Eric P Prinssen, Jürgen Wichmann, Brigitte L Kieffer, Abdel-Mouttalib Ouagazzal

Neurobiol Learn Mem· October 2012

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Post-marketing assessment of neuropsychiatric adverse events in influenza patients treated with oseltamivir: an updated review.
Stephen Toovey, Eric P Prinssen, Craig R Rayner, Bharat T Thakrar, Regina Dutkowski

Adv Ther· October 2012

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Role of the intestinal peptide transporter PEPT1 in oseltamivir absorption: in vitro and in vivo studies.
Agnès Poirier, Sara Belli, Christoph Funk, Michael B Otteneder, Renée Portmann, Eric Prinssen

Drug Metab Dispos· August 2012

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Further characterization of the prototypical nociceptin/orphanin FQ peptide receptor agonist Ro 64-6198 in rodent models of conflict anxiety and despair.
Celia Goeldner, Will Spooren, Jürgen Wichmann, Eric P Prinssen

Psychopharmacology (Berl)· July 2012

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Absence of central nervous system and hypothermic effects after single oral administration of high doses of oseltamivir in the rat.
Christian Freichel, Alexander Breidenbach, Gerhard Hoffmann, Annette Körner, Silvia Gatti, Eric P Prinssen

Basic Clin Pharmacol Toxicol· July 2012

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Lack of unwanted effects of oseltamivir carboxylate in juvenile rats after subcutaneous administration.
Christian Freichel, Alexander Breidenbach, Laurent Gand, Jonathan Toot, Thomas Weiser, Eric Prinssen

Basic Clin Pharmacol Toxicol· June 2012

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Imaging trait anxiety in high anxiety F344 rats: Focus on the dorsomedial prefrontal cortex.
Eric P Prinssen, Laurent B Nicolas, Steffen Klein, Christophe Grundschober, Cristina Lopez-Lopez

Eur Neuropsychopharmacol· June 2012

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Activation of nociceptin/orphanin FQ peptide receptors disrupts visual but not auditory sensorimotor gating in BALB/cByJ mice: comparison to dopamine receptor agonists.
Aurelia Ces, David Reiss, Ondine Walter, Jürgen Wichmann, Eric P Prinssen

Neuropsychopharmacology· January 2012

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CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor.
Lothar Lindemann, Georg Jaeschke, Aubin Michalon, Eric Vieira, Michael Honer, Eric P Prinssen

J Pharmacol Exp Ther· November 2011

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Development of a physiologically based model for oseltamivir and simulation of pharmacokinetics in neonates and infants.
Neil Parrott, Brian Davies, Gerhard Hoffmann, Annette Koerner, Thierry Lave, Eric Prinssen

Clin Pharmacokinet· September 2011

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