Publications by authors named "Henner Knust"

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Preclinical pharmacology of alogabat: a novel GABA-α5 positive allosteric modulator targeting neurodevelopmental disorders with impaired GABA signaling.
Giuseppe Cecere, Theresa M Ballard, Frederic Knoflach, Michael Honer, Joerg F Hipp, Henner Knust

Front Pharmacol· July 2025

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Basmisanil, a highly selective GABA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man.
Joerg F Hipp, Frederic Knoflach, Robert Comley, Theresa M Ballard, Michael Honer, Henner Knust

Sci Rep· April 2021

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Preclinical Evaluation of F-RO6958948, C-RO6931643, and C-RO6924963 as Novel PET Radiotracers for Imaging Tau Aggregates in Alzheimer Disease.
Michael Honer, Luca Gobbi, Henner Knust, Hiroto Kuwabara, Dieter Muri

J Nucl Med· April 2018

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Identification of Three Novel Radiotracers for Imaging Aggregated Tau in Alzheimer's Disease with Positron Emission Tomography.
Luca C Gobbi, Henner Knust, Matthias Körner, Michael Honer, Christian Czech

J Med Chem· September 2017

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Direct photocatalytic fluorination of benzylic C-H bonds with N-fluorobenzenesulfonimide.
Matthew B Nodwell, Abhimanyu Bagai, Shira D Halperin, Rainer E Martin, Henner Knust

Chem Commun (Camb)· July 2015

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Adventures in drug-like chemistry space: from oxetanes to spiroazetidines and beyond!
Mark Rogers-Evans, Henner Knust, Jean-Marc Plancher, Erick M Carreira, George Wuitschik

Chimia (Aarau)· May 2015

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Mapping the binding pocket of a novel, high-affinity, slow dissociating tachykinin NK3 receptor antagonist: biochemical and electrophysiological characterization.
Pari Malherbe, Frédéric Knoflach, Anne Marcuz, Claudia Bohnert, Michael Weber, Henner Knust

Neuropharmacology· November 2014

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Conformationally restricted pyrrolidines by intramolecular [2+2] photocycloaddition reactions.
Diego A Fort, Thomas J Woltering, Matthias Nettekoven, Henner Knust, Thorsten Bach

Chem Commun (Camb)· April 2013

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Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines as imaging agents for tau fibrils and β-amyloid plaques in Alzheimer's disease models.
Alexander Boländer, Daniel Kieser, Constantin Voss, Silvia Bauer, Christian Schön, Henner Knust

J Med Chem· November 2012

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Synthesis of fluorinated tricyclic scaffolds by intramolecular [2+2] photocycloaddition reactions.
Diego A Fort, Thomas J Woltering, Matthias Nettekoven, Henner Knust, Thorsten Bach

Angew Chem Int Ed Engl· October 2012

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Expanding the azaspiro[3.3]heptane family: synthesis of novel highly functionalized building blocks.
Johannes A Burkhard, Carine Guérot, Henner Knust, Erick M Carreira

Org Lett· January 2012

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Synthesis of novel angular spirocyclic azetidines.
Carine Guérot, Boris H Tchitchanov, Henner Knust, Erick M Carreira

Org Lett· February 2011

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Rational design of novel pyrrolidine derivatives as orally active neurokinin-3 receptor antagonists.
Hassen Ratni, Theresa M Ballard, Caterina Bissantz, Torsten Hoffmann, Philippe Jablonski, Henner Knust

Bioorg Med Chem Lett· November 2010

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Synthesis and structural analysis of a new class of azaspiro[3.3]heptanes as building blocks for medicinal chemistry.
Johannes A Burkhard, Carine Guérot, Henner Knust, Mark Rogers-Evans, Erick M Carreira

Org Lett· May 2010

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Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA(A) alpha5 inverse agonist series.
Guido Achermann, Theresa M Ballard, Francesca Blasco, Pierre-Emmanuel Broutin, Bernd Büttelmann, Henner Knust

Bioorg Med Chem Lett· October 2009

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Imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepines as potent and highly selective GABAA alpha5 inverse agonists with potential for the treatment of cognitive dysfunction.
Bernd Buettelmann, Theresa M Ballard, Rodolfo Gasser, Holger Fischer, Maria-Clemencia Hernandez, Henner Knust

Bioorg Med Chem Lett· October 2009

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The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment of cognitive dysfunction.
Henner Knust, Guido Achermann, Theresa Ballard, Bernd Buettelmann, Rodolfo Gasser

Bioorg Med Chem Lett· October 2009

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RO4938581, a novel cognitive enhancer acting at GABAA alpha5 subunit-containing receptors.
Theresa M Ballard, Frédéric Knoflach, Eric Prinssen, Edilio Borroni, Jeffrey A Vivian, Henner Knust

Psychopharmacology (Berl)· January 2009

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Total synthesis of (-)-reidispongiolide A, an actin-targeting macrolide isolated from the marine sponge Reidispongia coerulea.
Ian Paterson, Kate Ashton, Robert Britton, Giuseppe Cecere, Gaëlle Chouraqui, Henner Knust

Chem Asian J· February 2008

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Synthesis of antimicrofilament marine macrolides: synthesis and configurational assignment of a C5-C16 degradation fragment of reidispongiolide A.
Ian Paterson, Robert Britton, Kate Ashton, Henner Knust, Jonathan Stafford

Proc Natl Acad Sci U S A· August 2004

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A case study in conformation design: learning by doing.
Henner Knust, Reinhard W Hoffmann

Chem Rec· July 2004

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Toward the synthesis of reidispongiolide a: stereocontrolled synthesis of the C17-C22 and C23-C35 degradation fragments.
Ian Paterson, Kate Ashton, Robert Britton, Henner Knust

Org Lett· May 2003

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