Publications by authors named "Kate Ashton"

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LYMTACs:chimeric small molecules repurpose lysosomal membrane proteins for target protein relocalization and degradation.
Dhanusha A Nalawansha, Georgios Mazis, Gitte Husemoen, Kate S Ashton, Weixian Deng

Nat Commun· August 2025

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VIPER-TACs leverage viral E3 ligases for disease-specific targeted protein degradation.
Kyle Mangano, Robert G Guenette, Spencer Hill, Shiqian Li, Jeffrey J Liu, Kate S Ashton

Cell Chem Biol· March 2025

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Effectiveness and cost-effectiveness of radiofrequency denervation versus placebo for chronic and moderate to severe low back pain: study protocol for the RADICAL randomised controlled trial.
Kate E Ashton, Cathy Price, Leah Fleming, Ashley W Blom, Lucy Culliford

BMJ Open· July 2024

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Extended pleurectomy decortication and chemotherapy versus chemotherapy alone for pleural mesothelioma (MARS 2): a phase 3 randomised controlled trial.
Eric Lim, David Waller, Kelvin Lau, Jeremy Steele, Anthony Pope, Kate Ashton

Lancet Respir Med· June 2024

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Strategies to address recruitment to a randomised trial of surgical and non-surgical treatment for cancer: results from a complex recruitment intervention within the Mesothelioma and Radical Surgery 2 (MARS 2) study.
Nicola Mills, Nicola Farrar, Barbara Warnes, Kate E Ashton, Rosie Harris

BMJ Open· May 2024

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Protein-protein interfaces in molecular glue-induced ternary complexes: classification, characterization, and prediction.
Huan Rui, Kate S Ashton, Jaeki Min, Connie Wang, Patrick Ryan Potts

RSC Chem Biol· March 2023

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Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe.
Nuria A Tamayo, Matthew P Bourbeau, Jennifer R Allen, Kate S Ashton, Jian Jeffrey Chen

J Med Chem· March 2022

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Comparison of alternate preparative techniques on wall thickness in coronary artery bypass grafts: The HArVeST randomized controlled trial.
Gianni D Angelini, Tom Johnson, Lucy Culliford, Gavin Murphy, Kate Ashton

J Card Surg· June 2021

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Mesothelioma and Radical Surgery 2 (MARS 2): protocol for a multicentre randomised trial comparing (extended) pleurectomy decortication versus no (extended) pleurectomy decortication for patients with malignant pleural mesothelioma.
Eric Lim, Liz Darlison, John Edwards, Daisy Elliott, D A Fennell, Kate Ashton

BMJ Open· September 2020

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Preoperative VolumE Replacement therapy in DIabetic patients undergoing coronary artery bypass grafting surgery: results from an open parallel group randomized Controlled Trial (VeRDiCT).
Kunal Sarkar, Rosie A Harris, Sian Wells, Tracy Harris, Madeleine Clout, Kate Ashton

Interact Cardiovasc Thorac Surg· January 2020

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Discovery of a Covalent Inhibitor of KRAS (AMG 510) for the Treatment of Solid Tumors.
Brian A Lanman, Jennifer R Allen, John G Allen, Albert K Amegadzie, Kate S Ashton

J Med Chem· January 2020

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Three wound-dressing strategies to reduce surgical site infection after abdominal surgery: the Bluebelle feasibility study and pilot RCT.
Barnaby C Reeves, Leila Rooshenas, Rhiannon C Macefield, Mark Woodward, Nicky J Welton, Kate Ashton

Health Technol Assess· August 2019

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A mixed-methods feasibility and external pilot study to inform a large pragmatic randomised controlled trial of the effects of surgical wound dressing strategies on surgical site infections (Bluebelle Phase B): study protocol for a randomised controlled trial.

Trials· August 2017

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The Effects of Preoperative Volume Replacement in Diabetic Patients Undergoing Coronary Artery Bypass Grafting Surgery: Protocol for a Randomized Controlled Trial (VeRDiCT Trial).
Madeleine Clout, Tracy Harris, Chris Rogers, Lucy Culliford, Jodi Taylor, Kate Ashton

JMIR Res Protoc· June 2017

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Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N → S (nN → σ*S-X) Interaction for Conformational Constraint.
Lewis D Pennington, Michael D Bartberger, Michael D Croghan, Kristin L Andrews, Kate S Ashton

J Med Chem· December 2015

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Soaps and serenity: care the Cantonese way.
Kate Ashton

Br J Nurs· November 2015

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Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors.
Ryan P Wurz, Liping H Pettus, Kate Ashton, James Brown, Jian Jeffrey Chen

ACS Med Chem Lett· September 2015

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Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 4. Exploration of a novel binding pocket.
Fang-Tsao Hong, Mark H Norman, Kate S Ashton, Michael D Bartberger, Jie Chen

J Med Chem· July 2014

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Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series.
Nobuko Nishimura, Mark H Norman, Longbin Liu, Kevin C Yang, Kate S Ashton

J Med Chem· April 2014

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Nonracemic synthesis of GK-GKRP disruptor AMG-3969.
Matthew P Bourbeau, Kate S Ashton, Jie Yan, David J St Jean

J Org Chem· April 2014

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Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept.
Kate S Ashton, Kristin L Andrews, Marian C Bryan, Jie Chen, Kui Chen

J Med Chem· January 2014

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Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles.
David J St Jean, Kate S Ashton, Michael D Bartberger, Jie Chen, Samer Chmait

J Med Chem· January 2014

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Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors.
David J Lloyd, David J St Jean, Robert J M Kurzeja, Robert C Wahl, Klaus Michelsen, Kate S Ashton

Nature· December 2013

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WITHDRAWN: Reduced dietary salt for the prevention of cardiovascular disease.
Rod S Taylor, Kate E Ashton, Tiffany Moxham, Lee Hooper, Shah Ebrahim

Cochrane Database Syst Rev· September 2013

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Design and synthesis of novel amide AKT1 inhibitors with selectivity over CDK2.
Kate S Ashton, David J St Jean, Steve F Poon, Matthew R Lee, John G Allen

Bioorg Med Chem Lett· September 2011

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