Publications by authors named "David J Lloyd"

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Regenerative farming as climate action.
Mathew Stephen Alexanderson, Hanabeth Luke, David John Lloyd

J Environ Manage· December 2023

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GIPR gene expression in testis is mouse specific and can impact male mouse fertility.
Elizabeth A Killion, Rajaa Hussien, Artem Shkumatov, Rhian Davies, David J Lloyd

Andrology· May 2022

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GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys.
Shu-Chen Lu, Michelle Chen, Larissa Atangan, Elizabeth A Killion, Renee Komorowski, David J Lloyd

Cell Rep Med· May 2021

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Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor.
Xiaoshan Min, Junming Yie, Jinghong Wang, Ben C Chung, Ching-Shin Huang, David J Lloyd

MAbs· February 2021

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Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism.
Elizabeth A Killion, Michelle Chen, James R Falsey, Glenn Sivits, Todd Hager, David J Lloyd

Nat Commun· October 2020

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Glucose-Dependent Insulinotropic Polypeptide Receptor Therapies for the Treatment of Obesity, Do Agonists = Antagonists?
Elizabeth A Killion, Shu-Chen Lu, Madeline Fort, Yuichiro Yamada, Murielle M Véniant, David J Lloyd

Endocr Rev· January 2020

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Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models.
Elizabeth A Killion, Jinghong Wang, Junming Yie, Stone D-H Shi, Darren Bates, David J Lloyd

Sci Transl Med· December 2018

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Haploinsufficiency of the Insulin Receptor in the Presence of a Splice-Site Mutation in Ppp2r2a Results in a Novel Digenic Mouse Model of Type 2 Diabetes.
Michelle Goldsworthy, Ying Bai, Chi-Ming Li, Huanying Ge, Edwin Lamas, David J Lloyd

Diabetes· May 2016

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Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N → S (nN → σ*S-X) Interaction for Conformational Constraint.
Lewis D Pennington, Michael D Bartberger, Michael D Croghan, Kristin L Andrews, Kate S Ashton, David J Lloyd

J Med Chem· December 2015

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A gain-of-function mutation in adenylate cyclase 3 protects mice from diet-induced obesity.
Jeffrey L Pitman, Matthew C Wheeler, David J Lloyd, John R Walker, Richard J Glynne

PLoS One· October 2015

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Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis.
Nuria A Tamayo, Mark H Norman, Michael D Bartberger, Fang-Tsao Hong, Yunxin Bo, David J Lloyd

J Med Chem· June 2015

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Pharmacologic Effects of FGF21 Are Independent of the "Browning" of White Adipose Tissue.
Murielle M Véniant, Glenn Sivits, Joan Helmering, Renee Komorowski, Jae Lee, David J Lloyd

Cell Metab· May 2015

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Molecular targeting of the GK-GKRP pathway in diabetes.
Clarence Hale, David J Lloyd, Andrea Pellacani, Murielle M Véniant

Expert Opin Ther Targets· January 2015

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A mutation in Ampd2 is associated with nephrotic syndrome and hypercholesterolemia in mice.
Joan Helmering, Todd Juan, Chi Ming Li, Mark Chhoa, Will Baron, David J Lloyd

Lipids Health Dis· October 2014

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The effect of the G1-S transition checkpoint on an age structured cell cycle model.
Gary S Chaffey, David J B Lloyd, Anne C Skeldon, Norman F Kirkby

PLoS One· September 2014

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Participatory development and analysis of a fuzzy cognitive map of the establishment of a bio-based economy in the Humber region.
Alexandra S Penn, Christopher J K Knight, David J B Lloyd, Daniele Avitabile, Kasper Kok

PLoS One· July 2014

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Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 4. Exploration of a novel binding pocket.
Fang-Tsao Hong, Mark H Norman, Kate S Ashton, Michael D Bartberger, Jie Chen, David J Lloyd

J Med Chem· July 2014

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Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series.
Nobuko Nishimura, Mark H Norman, Longbin Liu, Kevin C Yang, Kate S Ashton, David J Lloyd

J Med Chem· April 2014

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Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept.
Kate S Ashton, Kristin L Andrews, Marian C Bryan, Jie Chen, Kui Chen, David J Lloyd

J Med Chem· January 2014

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Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles.
David J St Jean, Kate S Ashton, Michael D Bartberger, Jie Chen, Samer Chmait, David J Lloyd

J Med Chem· January 2014

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Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors.
David J Lloyd, David J St Jean, Robert J M Kurzeja, Robert C Wahl, Klaus Michelsen

Nature· December 2013

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Modelling and detecting tumour oxygenation levels.
Anne C Skeldon, Gary Chaffey, David J B Lloyd, Vineet Mohan, David A Bradley

PLoS One· March 2013

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FGF21 promotes metabolic homeostasis via white adipose and leptin in mice.
Murielle M Véniant, Clarence Hale, Joan Helmering, Michelle M Chen, Shanaka Stanislaus, David J Lloyd

PLoS One· March 2013

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Pharmacological targeting of glucagon and glucagon-like peptide 1 receptors has different effects on energy state and glucose homeostasis in diet-induced obese mice.
Wei Gu, David J Lloyd, Narumol Chinookswong, Renée Komorowski, Glenn Sivits

J Pharmacol Exp Ther· July 2011

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A volumetric method for quantifying atherosclerosis in mice by using microCT: comparison to en face.
David J Lloyd, Joan Helmering, Stephen A Kaufman, James Turk, Matt Silva

PLoS One· April 2011

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