Publications by authors named "Lewis D Pennington"

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Property-Based Drug Design Merits a Nobel Prize.
Lewis D Pennington, Matthew J Hesse, Dennis C Koester, Rory C McAtee, Alshaima'a M Qunies

J Med Chem· July 2024

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Total Synthesis as Training for Medicinal Chemistry.
Lewis D Pennington

ACS Med Chem Lett· February 2024

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Holistic drug design for multiparameter optimization in modern small molecule drug discovery.
Lewis D Pennington, Ingo Muegge

Bioorg Med Chem Lett· June 2021

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Positional Analogue Scanning: An Effective Strategy for Multiparameter Optimization in Drug Design.
Lewis D Pennington, Brian M Aquila, Younggi Choi, Roman A Valiulin, Ingo Muegge

J Med Chem· September 2020

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The Necessary Nitrogen Atom: A Versatile High-Impact Design Element for Multiparameter Optimization.
Lewis D Pennington, Demetri T Moustakas

J Med Chem· May 2017

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Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N → S (nN → σ*S-X) Interaction for Conformational Constraint.
Lewis D Pennington, Michael D Bartberger, Michael D Croghan, Kristin L Andrews, Kate S Ashton

J Med Chem· December 2015

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A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design.
Brett R Beno, Kap-Sun Yeung, Michael D Bartberger, Lewis D Pennington, Nicholas A Meanwell

J Med Chem· June 2015

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2,2'-Bi[benzo[b]thiophene]: an unexpected isolation of the benzo[b]thiophene dimer.
Eugene Y Cheung, Lewis D Pennington, Michael D Bartberger, Richard J Staples

Acta Crystallogr C Struct Chem· June 2014

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Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series.
Nobuko Nishimura, Mark H Norman, Longbin Liu, Kevin C Yang, Kate S Ashton, Lewis D Pennington

J Med Chem· April 2014

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Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept.
Kate S Ashton, Kristin L Andrews, Marian C Bryan, Jie Chen, Kui Chen, Lewis D Pennington

J Med Chem· January 2014

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Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles.
David J St Jean, Kate S Ashton, Michael D Bartberger, Jie Chen, Samer Chmait, Lewis D Pennington

J Med Chem· January 2014

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Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors.
David J Lloyd, David J St Jean, Robert J M Kurzeja, Robert C Wahl, Klaus Michelsen, Lewis D Pennington

Nature· December 2013

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Hydroxyethylamine-based inhibitors of BACE1: P₁-P₃ macrocyclization can improve potency, selectivity, and cell activity.
Lewis D Pennington, Douglas A Whittington, Michael D Bartberger, Steven R Jordan, Holger Monenschein

Bioorg Med Chem Lett· August 2013

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Design and preparation of a potent series of hydroxyethylamine containing β-secretase inhibitors that demonstrate robust reduction of central β-amyloid.
Matthew M Weiss, Toni Williamson, Safura Babu-Khan, Michael D Bartberger, James Brown, Lewis D Pennington

J Med Chem· November 2012

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Design and synthesis of potent, orally efficacious hydroxyethylamine derived β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.
Thomas A Dineen, Matthew M Weiss, Toni Williamson, Paul Acton, Safura Babu-Khan, Lewis D Pennington

J Med Chem· November 2012

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A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-Secretase.
Matthew R Kaller, Scott S Harried, Brian Albrecht, Patricia Amarante, Safura Babu-Khan, Lewis D Pennington

ACS Med Chem Lett· November 2012

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Structure guided P1' modifications of HEA derived β-secretase inhibitors for the treatment of Alzheimer's disease.
Holger Monenschein, Daniel B Horne, Michael D Bartberger, Stephen A Hitchcock, Thomas T Nguyen, Lewis D Pennington

Bioorg Med Chem Lett· June 2012

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Quinolinone-based agonists of S1P₁: use of a N-scan SAR strategy to optimize in vitro and in vivo activity.
Lewis D Pennington, Michael D Croghan, Kelvin K C Sham, Alexander J Pickrell, Paul E Harrington

Bioorg Med Chem Lett· January 2012

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Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core.
Paul E Harrington, Michael D Croghan, Christopher Fotsch, Mike Frohn, Brian A Lanman, Lewis D Pennington

ACS Med Chem Lett· January 2012

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4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1.
Lewis D Pennington, Kelvin K C Sham, Alexander J Pickrell, Paul E Harrington, Michael J Frohn

ACS Med Chem Lett· October 2011

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A unified strategy for enantioselective total synthesis of cladiellin and briarellin diterpenes: total synthesis of briarellins E and F and the putative structure of alcyonin and revision of its structure assignment.
Olivier Corminboeuf, Larry E Overman, Lewis D Pennington

J Org Chem· August 2009

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Structure-brain exposure relationships.
Stephen A Hitchcock, Lewis D Pennington

J Med Chem· December 2006

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Strategic use of pinacol-terminated Prins cyclizations in target-oriented total synthesis.
Larry E Overman, Lewis D Pennington

J Org Chem· September 2003

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Enantioselective total synthesis of briarellins E and F: the first total syntheses of briarellin diterpenes.
Olivier Corminboeuf, Larry E Overman, Lewis D Pennington

J Am Chem Soc· June 2003

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Total synthesis of the reputed structure of alcyonin and reassignment of its structure.
Olivier Corminboeuf, Larry E Overman, Lewis D Pennington

Org Lett· May 2003

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