Publications by authors named "Alexander Treiber"

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The orexin 1-selective receptor antagonist nivasorexant is a time-dependent inhibitor of CYP2C19 and CYP3A4.
Alexander Treiber, Fabienne Drouet, Swen Seeland, Florian Willecke, Jodi T Williams

Xenobiotica· April 2025

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Evaluating the efficacy of the selective orexin 1 receptor antagonist nivasorexant in an animal model of binge-eating disorder.
Michel Alexander Steiner, Luca Botticelli, Giorgio Bergamini, Emanuela Micioni Di Bonaventura, John Gatfield, Alexander Treiber

Int J Eat Disord· July 2024

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Reversible oxidation/reduction steps in the metabolic degradation of the glycerol side chain of the S1P modulator ponesimod.
Alexander Treiber, Swen Seeland, Jérôme Segrestaa, Cyrille Lescop, Martin H Bolli

Xenobiotica· April 2024

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The metabolism of the orexin-1 selective receptor antagonist nivasorexant.
Alexander Treiber, Swen Seeland, Belal Haschimi, Aude Weigel, Jodi T Williams

Xenobiotica· March 2024

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Discovery of Nivasorexant (ACT-539313): The First Selective Orexin-1 Receptor Antagonist (SO1RA) Investigated in Clinical Trials.
Jodi T Williams, Martin H Bolli, Christine Brotschi, Thierry Sifferlen, Michel A Steiner, Alexander Treiber

J Med Chem· February 2024

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Pyrazole derivatives as selective orexin-2 receptor antagonists (2-SORA): synthesis, structure-activity-relationship, and sleep-promoting properties in rats.
Christine Brotschi, Martin H Bolli, John Gatfield, Catherine Roch, Thierry Sifferlen, Alexander Treiber

RSC Med Chem· January 2024

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Effect of nivasorexant (ACT-539313), a selective orexin-1-receptor antagonist, on multiple cytochrome P450 probe substrates in vitro and in vivo using a cocktail approach in healthy subjects.
Benjamin Berger, Priska Kaufmann, Matthias Berse, Alexander Treiber, Nathalie Grignaschi

Pharmacol Res Perspect· October 2023

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CYP3A4 Catalyzes the Rearrangement of the Dual Orexin Receptor Antagonist Daridorexant to 4-Hydroxypiperidinol Metabolites.
Alexander Treiber, Hamed Aissaoui, Stéphane Delahaye, Sven Glutz, Julien Grimont

ChemMedChem· May 2023

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The metabolism of the dual orexin receptor antagonist daridorexant.
Alexander Treiber, Stephane Delahaye, Aude Weigel, Päivi Aeänismaa, John Gatfield

Xenobiotica· March 2023

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The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia Disorders.
Christoph Boss, John Gatfield, Christine Brotschi, Bibia Heidmann, Thierry Sifferlen, Alexander Treiber

ChemMedChem· December 2020

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The endothelin receptor antagonist macitentan for the treatment of pulmonary arterial hypertension: A cross-species comparison of its cytochrome P450 induction pattern.
Alexander Treiber, Stephane Delahaye, Swen Seeland, Carmela Gnerre

Pharmacol Res Perspect· August 2020

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From Oxadiazole to Triazole Analogues: Optimization toward a Dual Orexin Receptor Antagonist with Improved in vivo Efficacy in Dogs.
Christine Brotschi, Martin H Bolli, John Gatfield, Bibia Heidmann, Francois Jenck, Alexander Treiber

ChemMedChem· March 2020

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Oxadiazole Derivatives as Dual Orexin Receptor Antagonists: Synthesis, Structure-Activity Relationships, and Sleep-Promoting Properties in Rats.
Christine Brotschi, Catherine Roch, John Gatfield, Alexander Treiber, Jodi T Williams

ChemMedChem· July 2019

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Cross-species comparison of the metabolism and excretion of selexipag.
Tomohiko Ichikawa, Tetsuhiro Yamada, Alexander Treiber, Carmela Gnerre, Jérôme Segrestaa

Xenobiotica· March 2019

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The metabolism and drug-drug interaction potential of the selective prostacyclin receptor agonist selexipag.
Carmela Gnerre, Jérôme Segrestaa, Swen Seeland, Päivi Äänismaa, Thomas Pfeifer, Alexander Treiber

Xenobiotica· July 2018

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Pharmacokinetics of the selective prostacyclin receptor agonist selexipag in rats, dogs and monkeys.
Tomohiko Ichikawa, Tetsuhiro Yamada, Alexander Treiber, Carmela Gnerre, Kiyoko Nonaka

Xenobiotica· February 2018

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The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468.
Alexander Treiber, Ruben de Kanter, Catherine Roch, John Gatfield, Christoph Boss

J Pharmacol Exp Ther· September 2017

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The metabolism of the dual endothelin receptor antagonist macitentan in rat and dog.
Alexander Treiber, Tommaso Miraval, Martin H Bolli, Jacques-Alexis Funel, Jerome Segrestaa

Xenobiotica· October 2016

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Discovery of Highly Potent Dual Orexin Receptor Antagonists via a Scaffold-Hopping Approach.
Bibia Heidmann, John Gatfield, Catherine Roch, Alexander Treiber, Simone Tortoioli

ChemMedChem· October 2016

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Physiologically-Based Pharmacokinetic Modeling of Macitentan: Prediction of Drug-Drug Interactions.
Ruben de Kanter, Patricia N Sidharta, Stéphane Delahaye, Carmela Gnerre, Jerome Segrestaa, Alexander Treiber

Clin Pharmacokinet· March 2016

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4-((R)-2-{[6-((S)-3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic Acid Butyl Ester (ACT-246475) and Its Prodrug (ACT-281959), a Novel P2Y12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel.
Eva Caroff, Francis Hubler, Emmanuel Meyer, Dorte Renneberg, Carmela Gnerre, Alexander Treiber

J Med Chem· December 2015

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Substituted pyrrolidin-2-ones: Centrally acting orexin receptor antagonists promoting sleep. Part 2.
Thierry Sifferlen, Amandine Boller, Audrey Chardonneau, Emmanuelle Cottreel, John Gatfield, Alexander Treiber

Bioorg Med Chem Lett· May 2015

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ATP-induced cellular stress and mitochondrial toxicity in cells expressing purinergic P2X7 receptor.
Swen Seeland, Hélène Kettiger, Mark Murphy, Alexander Treiber, Jasmin Giller

Pharmacol Res Perspect· March 2015

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Pharmacokinetic interactions between simvastatin and setipiprant, a CRTH2 antagonist.
Martine Gehin, Patricia N Sidharta, Carmela Gnerre, Alexander Treiber, Atef Halabi

Eur J Clin Pharmacol· January 2015

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Structure-activity relationship, biological, and pharmacological characterization of the proline sulfonamide ACT-462206: a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist.
Christoph Boss, Catherine Roch-Brisbare, Michel A Steiner, Alexander Treiber, Hendrik Dietrich

ChemMedChem· November 2014

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