Publications by authors named "Catherine Brisbare-Roch"

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Discovery of substituted lactams as novel dual orexin receptor antagonists. Synthesis, preliminary structure-activity relationship studies and efforts towards improved metabolic stability and pharmacokinetic properties. Part 1.
Thierry Sifferlen, Amandine Boller, Audrey Chardonneau, Emmanuelle Cottreel, Johannes Hoecker, Catherine Brisbare-Roch

Bioorg Med Chem Lett· February 2014

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Structure-activity relationship studies and sleep-promoting activity of novel 1-chloro-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Part 2.
Thierry Sifferlen, Ralf Koberstein, Emmanuelle Cottreel, Amandine Boller, Thomas Weller, Catherine Brisbare-Roch

Bioorg Med Chem Lett· July 2013

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Discovery and characterization of ACT-335827, an orally available, brain penetrant orexin receptor type 1 selective antagonist.
Michel A Steiner, John Gatfield, Catherine Brisbare-Roch, Hendrik Dietrich, Alexander Treiber

ChemMedChem· June 2013

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Examining the role of endogenous orexins in hypothalamus-pituitary-adrenal axis endocrine function using transient dual orexin receptor antagonism in the rat.
Michel A Steiner, Carla Sciarretta, Catherine Brisbare-Roch, Daniel S Strasser, Rolf Studer

Psychoneuroendocrinology· April 2013

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Synthesis, structure-activity relationship studies, and identification of novel 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Part 1.
Thierry Sifferlen, Ralf Koberstein, Emmanuelle Cottreel, Amandine Boller, Thomas Weller, Catherine Brisbare-Roch

Bioorg Med Chem Lett· April 2013

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Differential effects of the dual orexin receptor antagonist almorexant and the GABA(A)-α1 receptor modulator zolpidem, alone or combined with ethanol, on motor performance in the rat.
Michel A Steiner, Hugues Lecourt, Daniel S Strasser, Catherine Brisbare-Roch, François Jenck

Neuropsychopharmacology· March 2011

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Orexin receptor antagonists: a new concept in CNS disorders?
John Gatfield, Catherine Brisbare-Roch, Francois Jenck, Christoph Boss

ChemMedChem· August 2010

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Novel pyrazolo-tetrahydropyridines as potent orexin receptor antagonists.
Thierry Sifferlen, Christoph Boss, Emmanuelle Cottreel, Ralf Koberstein, Markus Gude, Catherine Brisbare-Roch

Bioorg Med Chem Lett· March 2010

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Biomedical application of orexin/hypocretin receptor ligands in neuroscience.
Christoph Boss, Catherine Brisbare-Roch, Francois Jenck

J Med Chem· February 2009

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N-Glycine-sulfonamides as potent dual orexin 1/orexin 2 receptor antagonists.
Hamed Aissaoui, Ralf Koberstein, Cornelia Zumbrunn, John Gatfield, Catherine Brisbare-Roch

Bioorg Med Chem Lett· November 2008

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Promotion of sleep by targeting the orexin system in rats, dogs and humans.
Catherine Brisbare-Roch, Jasper Dingemanse, Ralf Koberstein, Petra Hoever, Hamed Aissaoui

Nat Med· February 2007

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