Publications by authors named "Peter Kast"

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(Reverse) Evolution of a Promiscuous Isochorismate Pyruvate Lyase into an Efficient Chorismate Mutase.
Dominik E Künzler, Luca Bressan, Linda Jäger, Marianne Gamper, Peter Kast

Biochemistry· August 2025

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Leveraging relaxation-optimized H-C correlations in 4-F-phenylalanine as atomic beacons for probing structure and dynamics of large proteins.
Andras Boeszoermenyi, Denitsa L Radeva, Sebastian Schindler, Veronica Valadares, Krishna M Padmanabha Das, Peter Kast

Nat Chem· June 2025

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Novel exported fusion enzymes with chorismate mutase and cyclohexadienyl dehydratase activity: Shikimate pathway enzymes teamed up in no man's land.
Christian Stocker, Tamjidmaa Khatanbaatar, Luca Bressan, Kathrin Würth-Roderer, Gabriele Cordara, Peter Kast

J Biol Chem· October 2023

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What Drives Chorismate Mutase to Top Performance? Insights from a Combined and Study.
Helen V Thorbjørnsrud, Luca Bressan, Tamjidmaa Khatanbaatar, Manuel Carrer, Kathrin Würth-Roderer, Peter Kast

Biochemistry· February 2023

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Evolving the naturally compromised chorismate mutase from Mycobacterium tuberculosis to top performance.
Jūrate Fahrig-Kamarauskait, Kathrin Würth-Roderer, Helen V Thorbjørnsrud, Susanne Mailand, Ute Krengel, Peter Kast

J Biol Chem· December 2020

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An evolution-based model for designing chorismate mutase enzymes.
William P Russ, Matteo Figliuzzi, Christian Stocker, Pierre Barrat-Charlaix, Michael Socolich, Peter Kast

Science· July 2020

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Inter-Enzyme Allosteric Regulation of Chorismate Mutase in Corynebacterium glutamicum: Structural Basis of Feedback Activation by Trp.
Daniel Burschowsky, Helen V Thorbjørnsrud, Joel B Heim, Ju Ratė Fahrig-Kamarauskaitė, Kathrin Würth-Roderer, Peter Kast

Biochemistry· February 2018

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Functional mapping of protein-protein interactions in an enzyme complex by directed evolution.
Kathrin Roderer, Martin Neuenschwander, Giosiana Codoni, Severin Sasso, Marianne Gamper, Peter Kast

PLoS One· May 2016

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Remote Control by Inter-Enzyme Allostery: A Novel Paradigm for Regulation of the Shikimate Pathway.
Steffi Munack, Kathrin Roderer, Mats Ökvist, Jurate Kamarauskaite, Severin Sasso, Peter Kast

J Mol Biol· March 2016

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Electrostatic transition state stabilization rather than reactant destabilization provides the chemical basis for efficient chorismate mutase catalysis.
Daniel Burschowsky, André van Eerde, Mats Ökvist, Alexander Kienhöfer, Peter Kast

Proc Natl Acad Sci U S A· December 2014

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Affinity maturation of a computationally designed binding protein affords a functional but disordered polypeptide.
Maren Butz, Peter Kast, Donald Hilvert

J Struct Biol· February 2014

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Evolution of a designed retro-aldolase leads to complete active site remodeling.
Lars Giger, Sami Caner, Richard Obexer, Peter Kast, David Baker

Nat Chem Biol· August 2013

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Directed evolution of a model primordial enzyme provides insights into the development of the genetic code.
Manuel M Müller, Jane R Allison, Narupat Hongdilokkul, Laurent Gaillon, Peter Kast

PLoS Genet· May 2013

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When inhibitors do not inhibit: critical evaluation of rational drug design targeting chorismate mutase from Mycobacterium tuberculosis.
Steffi Munack, Vincent Leroux, Kathrin Roderer, Mats Ökvist, André van Eerde, Peter Kast

Chem Biodivers· November 2012

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Robust design and optimization of retroaldol enzymes.
Eric A Althoff, Ling Wang, Lin Jiang, Lars Giger, Jonathan K Lassila, Peter Kast

Protein Sci· May 2012

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Making proteins with unnatural amino acids: the first engineered aminoacyl-tRNA synthetase revisited.
Peter Kast

Chembiochem· November 2011

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An N-terminal protein degradation tag enables robust selection of highly active enzymes.
Maren Butz, Martin Neuenschwander, Peter Kast, Donald Hilvert

Biochemistry· October 2011

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Consensus protein design without phylogenetic bias.
Christian Jäckel, Jesse D Bloom, Peter Kast, Frances H Arnold, Donald Hilvert

J Mol Biol· June 2010

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Design, selection, and characterization of a split chorismate mutase.
Manuel M Müller, Hajo Kries, Eva Csuhai, Peter Kast, Donald Hilvert

Protein Sci· May 2010

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13C isotope effect on the reaction catalyzed by prephenate dehydratase.
Jeremy Van Vleet, Andreas Kleeb, Peter Kast, Donald Hilvert, W W Cleland

Biochim Biophys Acta· April 2010

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A novel noncovalent complex of chorismate mutase and DAHP synthase from Mycobacterium tuberculosis: protein purification, crystallization and X-ray diffraction analysis.
Mats Okvist, Severin Sasso, Kathrin Roderer, Peter Kast, Ute Krengel

Acta Crystallogr Sect F Struct Biol Cryst Commun· October 2009

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Structure and function of a complex between chorismate mutase and DAHP synthase: efficiency boost for the junior partner.
Severin Sasso, Mats Okvist, Kathrin Roderer, Marianne Gamper, Giosiana Codoni, Peter Kast

EMBO J· July 2009

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Structural and functional investigation of a secreted chorismate mutase from the plant-parasitic nematode Heterodera schachtii in the context of related enzymes from diverse origins.
Bartel Vanholme, Peter Kast, Annelies Haegeman, Joachim Jacob, Wim Grunewald

Mol Plant Pathol· March 2009

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Structural reorganization and preorganization in enzyme active sites: comparisons of experimental and theoretically ideal active site geometries in the multistep serine esterase reaction cycle.
Adam J T Smith, Roger Müller, Miguel D Toscano, Peter Kast, Homme W Hellinga

J Am Chem Soc· November 2008

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Protein design by directed evolution.
Christian Jäckel, Peter Kast, Donald Hilvert

Annu Rev Biophys· August 2008

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