Publications by authors named "Richard Obexer"

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Enzymatic synthesis of key RNA therapeutic building blocks using simple phosphate donors.
Qinglong Meng, Caecilie Benckendorff, Charlotte Morrill, Ying Zhuo, Annette Egerström, Richard Obexer

Nat Commun· December 2025

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Efficient and selective energy transfer photoenzymes powered by visible light.
Rebecca Crawshaw, Ross Smithson, Johannes Hofer, Florence J Hardy, George W Roberts, Richard Obexer

Nat Chem· July 2025

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Maturation and Conformational Switching of a Designed Phase-Separating Polypeptide.
Alexander T Hilditch, Andrey Romanyuk, Lorna R Hodgson, Judith Mantell, Christopher R Neal, Richard Obexer

J Am Chem Soc· April 2024

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A non-canonical nucleophile unlocks a new mechanistic pathway in a designed enzyme.
Amy E Hutton, Jake Foster, Rebecca Crawshaw, Florence J Hardy, Linus O Johannissen, Richard Obexer

Nat Commun· March 2024

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Assembling membraneless organelles from de novo designed proteins.
Alexander T Hilditch, Andrey Romanyuk, Stephen J Cross, Richard Obexer, Jennifer J McManus

Nat Chem· January 2024

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Engineering Enzymes for Environmental Sustainability.
Emily Radley, John Davidson, Jake Foster, Richard Obexer, Elizabeth L Bell

Angew Chem Int Ed Engl· December 2023

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Engineering Enzymes for Environmental Sustainability.
Emily Radley, John Davidson, Jake Foster, Richard Obexer, Elizabeth L Bell

Angew Chem Weinheim Bergstr Ger· December 2023

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A designed photoenzyme for enantioselective [2+2] cycloadditions.
Jonathan S Trimble, Rebecca Crawshaw, Florence J Hardy, Colin W Levy, Murray J B Brown, Richard Obexer

Nature· November 2022

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De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition.
Erich Stefan, Richard Obexer, Susanne Hofmann, Khanh Vu Huu, Yichao Huang

Elife· April 2021

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One-Pot Ribosomal Synthesis of Macrocyclic Depsipeptides.
Masanobu Nagano, Yichao Huang, Richard Obexer, Hiroaki Suga

J Am Chem Soc· March 2021

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Strategies for transitioning macrocyclic peptides to cell-permeable drug leads.
Louise J Walport, Richard Obexer, Hiroaki Suga

Curr Opin Biotechnol· December 2017

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Efficient laboratory evolution of computationally designed enzymes with low starting activities using fluorescence-activated droplet sorting.
Richard Obexer, Moritz Pott, Cathleen Zeymer, Andrew D Griffiths, Donald Hilvert

Protein Eng Des Sel· July 2017

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Exploring sequence space: harnessing chemical and biological diversity towards new peptide leads.
Richard Obexer, Louise J Walport, Hiroaki Suga

Curr Opin Chem Biol· June 2017

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Emergence of a catalytic tetrad during evolution of a highly active artificial aldolase.
Richard Obexer, Alexei Godina, Xavier Garrabou, Peer R E Mittl, David Baker

Nat Chem· January 2017

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Efficient laboratory evolution of computationally designed enzymes with low starting activities using fluorescence-activated droplet sorting.
Richard Obexer, Moritz Pott, Cathleen Zeymer, Andrew D Griffiths, Donald Hilvert

Protein Eng Des Sel· September 2016

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Evolution of a designed retro-aldolase leads to complete active site remodeling.
Lars Giger, Sami Caner, Richard Obexer, Peter Kast, David Baker

Nat Chem Biol· August 2013

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