Publications by authors named "Peter S Hodder"

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Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition.
Michael R Wood, Meredith J Noetzel, James C Tarr, Alice L Rodriguez, Atin Lamsal, Peter S Hodder

Bioorg Med Chem Lett· September 2016

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Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core.
Michael R Wood, Meredith J Noetzel, Julie L Engers, Katrina A Bollinger, Bruce J Melancon, Peter S Hodder

Bioorg Med Chem Lett· July 2016

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Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.
Stuart L Schreiber, Joanne D Kotz, Min Li, Jeffrey Aubé, Christopher P Austin, Peter S Hodder

Cell· June 2015

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Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival.
Jae Won Chang, Andrea M Zuhl, Anna E Speers, Sherry Niessen, Steven J Brown, Peter S Hodder

ACS Chem Biol· April 2015

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Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis.
Nan Zhao, Crystal M Darby, Jennifer Small, Daniel A Bachovchin, Xiuju Jiang, Peter S Hodder

ACS Chem Biol· February 2015

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Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro.
Timothy P Spicer, Jianwen Jiang, Alexander B Taylor, Jun Yong Choi, P John Hart, Peter S Hodder

J Med Chem· November 2014

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Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β.
Franck Madoux, Claudia Tredup, Timothy P Spicer, Louis Scampavia, Peter S Chase, Peter S Hodder

Biopolymers· September 2014

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Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380).
Patrick R Gentry, Masaya Kokubo, Thomas M Bridges, Meredith J Noetzel, Hyekyung P Cho, Peter S Hodder

J Med Chem· September 2014

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Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe.
Patrick R Gentry, Masaya Kokubo, Thomas M Bridges, Hyekyung P Cho, Emery Smith, Peter S Hodder

ChemMedChem· August 2014

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Transitioning pharmacoperones to therapeutic use: in vivo proof-of-principle and design of high throughput screens.
P Michael Conn, David C Smithson, Peter S Hodder, M David Stewart, Richard R Behringer

Pharmacol Res· May 2014

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Discovery, design and synthesis of a selective S1P(3) receptor allosteric agonist.
Miguel Guerrero, Ramulu Poddutoori, Mariangela Urbano, Xuemei Peng, Timothy P Spicer, Peter S Hodder

Bioorg Med Chem Lett· December 2013

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Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375).
Patrick R Gentry, Masaya Kokubo, Thomas M Bridges, Nathan R Kett, Joel M Harp, Peter S Hodder

J Med Chem· November 2013

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Discovery of ML326: The first sub-micromolar, selective M5 PAM.
Patrick R Gentry, Thomas M Bridges, Atin Lamsal, Paige N Vinson, Emery Smith, Peter S Hodder

Bioorg Med Chem Lett· May 2013

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Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes.
Alexander Adibekian, Brent R Martin, Jae Won Chang, Ku-Lung Hsu, Katsunori Tsuboi, Peter S Hodder

J Am Chem Soc· June 2012

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A high-throughput assay for the identification of drugs against late-stage Plasmodium falciparum gametocytes.
Christopher L Peatey, Timothy P Spicer, Peter S Hodder, Katharine R Trenholme, Donald L Gardiner

Mol Biochem Parasitol· December 2011

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A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors.
Anna Mari Lone, Daniel A Bachovchin, David B Westwood, Anna E Speers, Timothy P Spicer, Peter S Hodder

J Am Chem Soc· August 2011

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Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.
Daniel A Bachovchin, Justin T Mohr, Anna E Speers, Chu Wang, Jacob M Berlin, Peter S Hodder

Proc Natl Acad Sci U S A· April 2011

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NH-1,2,3-Triazole-based Inhibitors of the VIM-2 Metallo-β-Lactamase: Synthesis and Structure-Activity Studies.
Timo Weide, S Adrian Saldanha, Dmitriy Minond, Timothy P Spicer, Joseph R Fotsing, Peter S Hodder

ACS Med Chem Lett· July 2010

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Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9).
Daniel A Bachovchin, Monique R Wolfe, Kim Masuda, Steven J Brown, Timothy P Spicer, Peter S Hodder

Bioorg Med Chem Lett· April 2010

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Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening.
Shaun P Brothers, S Adrian Saldanha, Timothy P Spicer, Michael Cameron, Becky A Mercer, Peter S Hodder

Mol Pharmacol· January 2010

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