Publications by authors named "David C Smithson"

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Development and Qualification of Analytical Methods to Support Low Concentration Drug Product in-use Studies.
Laura Zheng, Gary Console, Christopher Wang, Kevin Whang, Hau-Ping Ting, David C Smithson

J Pharm Sci· March 2024

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Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain.
Yu Zhao, Patrick R Cushing, David C Smithson, Maria Pellegrini, Alexandre A Pletnev

Biosci Rep· August 2018

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Correction: Cysteine modification reveals an allosteric inhibitory site on the CAL PDZ domain.
Yu Zhao, Patrick R Cushing, David C Smithson, Maria Pellegrini, Alexandre A Pletnev

Biosci Rep· August 2018

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Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening.
Diana Ortiz, W Armand Guiguemde, Jared T Hammill, Angela K Carrillo, Yizhe Chen, David C Smithson

PLoS Negl Trop Dis· December 2017

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Transitioning pharmacoperones to therapeutic use: in vivo proof-of-principle and design of high throughput screens.
P Michael Conn, David C Smithson, Peter S Hodder, M David Stewart, Richard R Behringer

Pharmacol Res· May 2014

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High-throughput screen for pharmacoperones of the vasopressin type 2 receptor.
P Michael Conn, Emery Smith, Peter Hodder, Jo Ann Janovick, David C Smithson

J Biomol Screen· September 2013

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Therapeutic rescue of misfolded/mistrafficked mutants: automation-friendly high-throughput assays for identification of pharmacoperone drugs of GPCRs.
David C Smithson, Jo Ann Janovick, P Michael Conn

Methods Enzymol· July 2013

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Optimization of the electrophile of chloronitrobenzamide leads active against Trypanosoma brucei.
Jong Yeon Hwang, David C Smithson, Gloria Holbrook, Fangyi Zhu, Michele C Connelly

Bioorg Med Chem Lett· July 2013

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Discovery of potent and selective inhibitors of Trypanosoma brucei ornithine decarboxylase.
David C Smithson, Jeongmi Lee, Anang A Shelat, Margaret A Phillips, R Kiplin Guy

J Biol Chem· May 2010

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Chemical genetics of Plasmodium falciparum.
W Armand Guiguemde, Anang A Shelat, David Bouck, Sandra Duffy, Gregory J Crowther, David C Smithson

Nature· May 2010

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Identification and characterization of the first small molecule inhibitor of MDMX.
Damon Reed, Ying Shen, Anang A Shelat, Leggy A Arnold, Antonio M Ferreira, David C Smithson

J Biol Chem· April 2010

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Optimization of a non-radioactive high-throughput assay for decarboxylase enzymes.
David C Smithson, Anang A Shelat, Jeffrey Baldwin, Margaret A Phillips, R Kiplin Guy

Assay Drug Dev Technol· April 2010

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Podophyllotoxin analogues active versus Trypanosoma brucei.
Md Jashim Uddin, David C Smithson, Kristin M Brown, Brenda C Crews, Michele Connelly

Bioorg Med Chem Lett· March 2010

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