Publications by authors named "Philip D Edwards"

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Biochemical characterization and in vitro activity of AZ513, a noncovalent, reversible, and noncompetitive inhibitor of fatty acid amide hydrolase.
Clay W Scott, Gaochao Tian, Xiao Hong Yu, Kathy A Paschetto, Dee E Wilkins, Philip D Edwards

Eur J Pharmacol· September 2011

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Discovery of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as selective antagonists of the kappa opioid receptor. Part 1.
Todd A Brugel, Reed W Smith, Michael Balestra, Christopher Becker, Thalia Daniels, Philip D Edwards

Bioorg Med Chem Lett· October 2010

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An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes.
Jeffrey S Albert, Niklas Blomberg, Alexander L Breeze, Alastair J H Brown, Jeremy N Burrows, Philip D Edwards

Curr Top Med Chem· December 2007

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Discovery of a novel warhead against beta-secretase through fragment-based lead generation.
Stefan Geschwindner, Lise-Lotte Olsson, Jeffrey S Albert, Johanna Deinum, Philip D Edwards

J Med Chem· November 2007

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Application of fragment-based lead generation to the discovery of novel, cyclic amidine beta-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency.
Philip D Edwards, Jeffrey S Albert, Mark Sylvester, David Aharony, Donald Andisik

J Med Chem· November 2007

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Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretase.
Miles Congreve, David Aharony, Jeffrey Albert, Owen Callaghan, James Campbell, Philip D Edwards

J Med Chem· March 2007

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Surviving the lethal triad of trauma: a case from Kosovo.
Richard J Guy, Philip D Edwards, Kurt A Fichtner

J R Nav Med Serv· April 2004

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Synthesis and physical characterization of a P1 arginine combinatorial library, and its application to the determination of the substrate specificity of serine peptidases.
Stephen T Furlong, Russell C Mauger, Anne M Strimpler, Yi-Ping Liu, Frank X Morris, Philip D Edwards

Bioorg Med Chem· November 2002

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Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines.
Gaochao Tian, Cynthia D Sobotka-Briner, John Zysk, Xiaodong Liu, Cynthia Birr, Philip D Edwards

J Biol Chem· August 2002

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