Publications by authors named "Philip Ho"

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Long-term oral glucocerebrosidase activator reduces soluble α-synuclein oligomer accumulation in Parkinsonian LRRK2 mutant mouse brain.
Zoe Yuen-Kiu Choi, Huifang Liu, Eunice Eun-Seo Chang, Shirley Yin-Yu Pang, Ivy Lingyi Luo, Shu-Leong Ho, Philip Wing-Lok Ho

NPJ Parkinsons Dis· December 2025

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Activation of chaperone-mediated autophagy suppresses glioblastoma by promoting wild-type IDH1/isocitrate dehydrogenase 1 degradation.
Wanjun Tang, Bo Chen, Philip Wing-Lok Ho, Qiyu Zheng, Cherry Tsz-Yee Ng

Autophagy· November 2025

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Affective phenotypes in heterozygous R1441G knock-in mice.
Marcus H F Ng, Jimmy W Y Lam, Zoe Y K Choi, Hui-Fang Liu, Philip W L Ho

Front Genet· September 2025

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Cranial gunshot wounds: comparative analysis of management and outcomes in a United Kingdom Major Trauma Centre and the United States.
Azam Ali Baig, Sheikh Momin, Philip Ho, Faheem Anwar, Georgina Shallard

Br J Neurosurg· May 2025

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Effects of Meditation and Yoga on Anxiety, Depression and Chronic Inflammation in Patients with Parkinson's Disease: A Randomized Clinical Trial.
Jojo Yan Yan Kwok, Lily Man Lee Chan, Charis Ann Lai, Philip Wing Lok Ho, Zoe Yuen-Kiu Choi, Edmond Pui Hang Choi, Rainbow Tin Hung Ho

Psychother Psychosom· April 2025

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Loss of mitochondrial Ca response and CaMKII/ERK activation by LRRK2 mutation correlate with impaired depolarization-induced mitophagy.
Eunice Eun-Seo Chang, Huifang Liu, Zoe Yuen-Kiu Choi, Yasine Malki, Steffi Xi-Yue Zhang, Shu-Leong Ho, Philip Wing-Lok Ho

Cell Commun Signal· October 2024

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A randomized controlled trial on the effects and acceptability of individual mindfulness techniques - meditation and yoga - on anxiety and depression in people with Parkinson's disease: a study protocol.
Jojo Yan Yan Kwok, Man Auyeung, Shirley Yin Yu Pang, Philip Wing Lok Ho, Doris Sau Fung Yu, Rainbow Tin Hung Ho

BMC Complement Med Ther· July 2023

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In vivo overexpression of synaptogyrin-3 promotes striatal synaptic dopamine uptake in LRRK2  mutant mouse model of Parkinson's disease.
Philip Wing-Lok Ho, Lingfei Li, Hui-Fang Liu, Zoe Yuen-Kiu Choi, Eunice Eun Seo Chang, Shu-Leong Ho

Brain Behav· February 2023

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Long-term inhibition of mutant LRRK2 hyper-kinase activity reduced mouse brain α-synuclein oligomers without adverse effects.
Philip Wing-Lok Ho, Eunice Eun-Seo Chang, Chi-Ting Leung, Huifang Liu, Yasine Malki, Zoe Yuen-Kiu Choi, Judith Choi-Wo Mak, Shu-Leong Ho

NPJ Parkinsons Dis· September 2022

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Transcriptional Regulation of the Synaptic Vesicle Protein Synaptogyrin-3 () Gene: The Effects of NURR1 on Its Expression.
Lingfei Li, Philip Wing-Lok Ho, Huifang Liu, Shirley Yin-Yu Pang, Eunice Eun-Seo Chang, Zoe Yuen-Kiu Choi, Shu-Leong Ho

Int J Mol Sci· March 2022

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LRRK2 mutant knock-in mouse models: therapeutic relevance in Parkinson's disease.
Eunice Eun Seo Chang, Philip Wing-Lok Ho, Hui-Fang Liu, Shirley Yin-Yu Pang, Chi-Ting Leung, Zoe Yuen-Kiu Choi, Shu-Leong Ho

Transl Neurodegener· February 2022

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LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson's disease.
Shirley Yin-Yu Pang, Rachel Cheuk Nam Lo, Philip Wing-Lok Ho, Hui-Fang Liu, Eunice Eun Seo Chang, Zoe Yuen-Kiu Choi, Shu-Leong Ho

Transl Neurodegener· January 2022

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Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2 mice.
Huifang Liu, Philip Wing-Lok Ho, Chi-Ting Leung, Shirley Yin-Yu Pang, Eunice Eun Seo Chang, Zoe Yuen-Kiu Choi, Shu-Leong Ho

Autophagy· October 2021

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Daniel J Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Khosrow Adeli, Holger W Auner, Seung-Hoon Baek, Shounak Baksi, Lionel Berthoux, Rhoderick E Brown, Andreia Neves Carvalho, Marzanna Cechowska-Pasko, Zhong Chen, King-Ho Cheung, Dong-Hyung Cho, Seong-Kyu Choe, Augustine M K Choi, Mary E Choi, Kamalika Roy Choudhury, Norman S Chow, Seockhoon Chung, Iwona A Ciechomska, Hormos Salimi Dafsari, Nicholas D Demers, Hongbin Deng, Thomas Efferth, Gholamreza Fazeli, Anthony O Fedele, Thomas A Ferguson, Anthony W Ferrante, Shou-Jiang Gao, Wanzhong Ge, Manosij Ghosh, Alexander Greenhough, Kishore Guda, Hongqing Guo, Maho Hamasaki, Thomas S Hays, Emmanuel A Ho, Idy H T Ho, Philip Wing-Lok Ho, Shu-Leong Ho, Wan Yun Ho, G Aaron Hobbs, Mark Hochstrasser, Peter H M Hoet, Daniel Hofius, Paul Hofman, Carina I Holmberg, Jose R Hombrebueno, Chang-Won Hong Yi-Ren Hong, Lora V Hooper, Thorsten Hoppe, Rastislav Horos, Yujin Hoshida, Chongmin Huan, Shohreh Issazadeh-Navikas, Thomas E Jensen, Hongchuan Jin, Widuri Kho, Noopur V Khobrekar, Jin-Hoi Kim, Kerri J Kinghorn, Thomas Klopstock, Hotaka Kobayashi, Young Ho Koh, Nicholas T Ktistakis, Thomas Kukar, Ashok Kumar, Ho Jeong Kwon, Nicholas F LaRusso, Yong-Ho Lee, Guanghong Liao, Dar-Shong Lin, Xiao-Hong Liu, Senka Ljubojevic-Holzer, Jia-Hong Lu, Honglin Luo, Shouqing Luo, Alex Lyakhovich, Quan-Hong Ma, Thomas G McWilliams, Jose F Moruno-Manchon, Subhadip Mukhopadhyay, Ashok Munjal, Jihoon Nah, Thomas Neill, Thomas P Neufeld, Hong-Min Ni, Zhenhong Ni, Thorsten Pfirrmann, Ainhoa Plaza-Zabala, Thomas Pulinilkunnil, Sumit Rathore, Hongmei Ren, Kasper M A Rouschop, Avnika Ashok Ruparelia, Amirhossein Sahebkar, Ashok K Saluja, Vanessa Sancho-Shimizu, J Thomas Sanderson, Anthony H V Schapira, Romana Schober, Alejandra C Schoijet, Micah B Schott, Hongtao Shen, Ying-Hong Shi, Kahori Shiba-Fukushima, Christopher J Shoemaker, Shahla Shojaei, Ikuo Shoji, Hong-Bing Shu, Rohit Anthony Sinha, Peter B Stathopulos, Zhongjie Sun, Stephen Cho Wing Sze, Chong Teik Tan, Lars Tatenhorst, Sufi Mary Thomas, Paul G Thomes, Andrew Thorburn, Thomas Thum, Holm H Uhlig, Thomas Vaccari, Ilse Vanhorebeek, Olga V Voitsekhovskaja, Hong-Gang Wang, Zhouguang Wang, Maxinne Watchon, Thomas Wollert, Jack Ho Wong, Shengzhou Wu, Xiaohong Wu, Hongguang Xia, Hong-Tao Xiao, Zhonglin Xie, Honghong Yao, Zhou Yu, Jeanho Yun, Hong Zhang, Hong Zhang, Honghe Zhang, Shizhong Zheng, Qing Zhong, Ao Zhou, Ben Zhou, Cefan Zhou, Gang Zhou, Hao Zhou, Hong Zhou, Hongbo Zhou, Jie Zhou, Jing Zhou, Jing Zhou, Jiyong Zhou, Kailiang Zhou, Rongjia Zhou, Xu-Jie Zhou, Yanshuang Zhou, Yinghong Zhou, Yubin Zhou, Zheng-Yu Zhou, Zhou Zhou, Hongxin Zhu, Xiaohong Zhuang

Autophagy· January 2021

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Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA).
Philip Wing-Lok Ho, Chi-Ting Leung, Huifang Liu, Shirley Yin-Yu Pang, Colin Siu-Chi Lam, Shu-Leong Ho

Autophagy· February 2020

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The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson's disease.
Shirley Yin-Yu Pang, Philip Wing-Lok Ho, Hui-Fang Liu, Chi-Ting Leung, Lingfei Li, Shu-Leong Ho

Transl Neurodegener· August 2019

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Absence of Tumor on Repeat Transurethral Resection of Bladder Tumor Does Not Predict Final Pathologic T0 Stage in Bladder Cancer Treated with Radical Cystectomy.
Janet Baack Kukreja, Sima Porten, Vishnukamal Golla, Philip Levy Ho, Graciela Noguera-Gonzalez

Eur Urol Focus· September 2018

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Activation of hypothalamic RIP-Cre neurons promotes beiging of WAT via sympathetic nervous system.
Baile Wang, Ang Li, Xiaomu Li, Philip Wl Ho, Donghai Wu

EMBO Rep· April 2018

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Development of phospho-specific Rab protein antibodies to monitor activity of the LRRK2 Parkinson's disease kinase.
Pawel Lis, Sophie Burel, Martin Steger, Matthias Mann, Fiona Brown, Janice L Holton, Philip Winglok Ho, Shu-Leong Ho, Meng-Yun Chou

Biochem J· January 2018

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Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson's disease.
Hui-Fang Liu, Philip Wing-Lok Ho, Gideon Chi-Ting Leung, Colin Siu-Chi Lam, Shirley Yin-Yu Pang, Shu-Leong Ho

Sci Rep· January 2017

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Deficiency of Cks1 Leads to Learning and Long-Term Memory Defects and p27 Dependent Formation of Neuronal Cofilin Aggregates.
Alexander Kukalev, Yiu-Ming Ng, Limei Ju, Amal Saidi, Sophie Lane, Philip Wing-Lok Ho

Cereb Cortex· January 2017

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Positive association of collagen type I with non-muscle invasive bladder cancer progression.
Michael Brooks, Qianxing Mo, Ross Krasnow, Philip Levy Ho, Yu-Cheng Lee

Oncotarget· December 2016

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Chronic adiponectin deficiency leads to Alzheimer's disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice.
Roy Chun-Laam Ng, On-Yin Cheng, Min Jian, Jason Shing-Cheong Kwan, Philip Wing-Lok Ho, Lena Lei Zhou, Ruby Lai-Chong Hoo, Koon Ho Chan

Mol Neurodegener· November 2016

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Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors.
Genta Ito, Kristina Katsemonova, Francesca Tonelli, Pawel Lis, Marco A S Baptista, Philip Wing-Lok Ho, Shu-Leong Ho

Biochem J· September 2016

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Revealing ecological risks of priority endocrine disrupting chemicals in four marine protected areas in Hong Kong through an integrative approach.
Elvis Genbo Xu, Philip Wing-Lok Ho, Zero Tse, Shu-Leong Ho, Kenneth Mei Yee Leung

Environ Pollut· August 2016

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